FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139848240> ?p ?o ?g. }

• W2139848240 endingPage "311" @default.
• W2139848240 startingPage "304" @default.
• W2139848240 abstract "Endocrine disrupters (EDs) are environment and food contaminants known to alter metabolic functions of mammals by interfering with specific endocrine pathways. Many EDs act on steroid hormone target cells by interacting with intracellular receptors (IRs) like estrogen receptors, androgen receptors, and thyroid hormone receptors; other receptors may be engaged. IRs are ligand-operated transcription factors acting in concert with general or cell-specific coregulators. The newly acquired awareness on the panoply of IR functions has increased the concern on potential, unsought, harmful effects of EDs on human health and has questioned the capability of currently available methodologies to identify and study EDs in the environment and in the food chain. Indeed, current in vivo and in vitro methodologies restrict the analysis to very specific organs or cell systems, with obvious limitations in predicting the systemic metabolic consequences of ED exposure. The emphasis recently laid by Regulatory Authorities, including European Center for the Validation of Alternative Methods, on the generation of in vitro model systems for toxicological analyses discouraged the development of models suitable to envision the whole spectrum of ED body actions required when studying compounds acting through IRs. Molecular imaging now provides the opportunity to quantify ED effects in living organisms enabling, for the first time, to acquire a full comprehension of the systemic effects of acute and prolonged exposure to EDs, solving the issue of the potential harm due to repeated low-dose exposure. The systems here reviewed are of unquestionable toxicological relevance and need to be taken into consideration to improve the methodology currently available and in use." @default.
• W2139848240 created "2016-06-24" @default.
• W2139848240 creator A5014556490 @default.
• W2139848240 creator A5052037610 @default.
• W2139848240 creator A5055666393 @default.
• W2139848240 creator A5085152154 @default.
• W2139848240 date "2008-09-15" @default.
• W2139848240 modified "2023-10-16" @default.
• W2139848240 title "Molecular Imaging, an Innovative Methodology for Whole-Body Profiling of Endocrine Disrupter Action" @default.
• W2139848240 cites W1965458815 @default.
• W2139848240 cites W1976856900 @default.
• W2139848240 cites W1978022044 @default.
• W2139848240 cites W1987104253 @default.
• W2139848240 cites W1997157738 @default.
• W2139848240 cites W2000379502 @default.
• W2139848240 cites W2001861670 @default.
• W2139848240 cites W2002842589 @default.
• W2139848240 cites W2013240431 @default.
• W2139848240 cites W2013398164 @default.
• W2139848240 cites W2021494570 @default.
• W2139848240 cites W2028343111 @default.
• W2139848240 cites W2036382924 @default.
• W2139848240 cites W2045197131 @default.
• W2139848240 cites W2046051517 @default.
• W2139848240 cites W2055375060 @default.
• W2139848240 cites W2061639312 @default.
• W2139848240 cites W2062244421 @default.
• W2139848240 cites W2070131786 @default.
• W2139848240 cites W2072173628 @default.
• W2139848240 cites W2073417234 @default.
• W2139848240 cites W2076907968 @default.
• W2139848240 cites W2078537140 @default.
• W2139848240 cites W2082029117 @default.
• W2139848240 cites W2082532013 @default.
• W2139848240 cites W2094888609 @default.
• W2139848240 cites W2101738855 @default.
• W2139848240 cites W2111455017 @default.
• W2139848240 cites W2111650618 @default.
• W2139848240 cites W2113732478 @default.
• W2139848240 cites W2114380158 @default.
• W2139848240 cites W2115682705 @default.
• W2139848240 cites W2115940794 @default.
• W2139848240 cites W2150524562 @default.
• W2139848240 cites W2165202637 @default.
• W2139848240 cites W2166259817 @default.
• W2139848240 cites W2170405846 @default.
• W2139848240 doi "https://doi.org/10.1093/toxsci/kfn191" @default.
• W2139848240 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18794234" @default.
• W2139848240 hasPublicationYear "2008" @default.
• W2139848240 type Work @default.
• W2139848240 sameAs 2139848240 @default.
• W2139848240 citedByCount "13" @default.
• W2139848240 countsByYear W21398482402014 @default.
• W2139848240 countsByYear W21398482402015 @default.
• W2139848240 countsByYear W21398482402016 @default.
• W2139848240 crossrefType "journal-article" @default.
• W2139848240 hasAuthorship W2139848240A5014556490 @default.
• W2139848240 hasAuthorship W2139848240A5052037610 @default.
• W2139848240 hasAuthorship W2139848240A5055666393 @default.
• W2139848240 hasAuthorship W2139848240A5085152154 @default.
• W2139848240 hasBestOaLocation W21398482401 @default.
• W2139848240 hasConcept C104317684 @default.
• W2139848240 hasConcept C109115496 @default.
• W2139848240 hasConcept C121608353 @default.
• W2139848240 hasConcept C134018914 @default.
• W2139848240 hasConcept C170493617 @default.
• W2139848240 hasConcept C46699223 @default.
• W2139848240 hasConcept C530470458 @default.
• W2139848240 hasConcept C54355233 @default.
• W2139848240 hasConcept C55493867 @default.
• W2139848240 hasConcept C63932345 @default.
• W2139848240 hasConcept C70721500 @default.
• W2139848240 hasConcept C71315377 @default.
• W2139848240 hasConcept C84606932 @default.
• W2139848240 hasConcept C86339819 @default.
• W2139848240 hasConcept C86803240 @default.
• W2139848240 hasConceptScore W2139848240C104317684 @default.
• W2139848240 hasConceptScore W2139848240C109115496 @default.
• W2139848240 hasConceptScore W2139848240C121608353 @default.
• W2139848240 hasConceptScore W2139848240C134018914 @default.
• W2139848240 hasConceptScore W2139848240C170493617 @default.
• W2139848240 hasConceptScore W2139848240C46699223 @default.
• W2139848240 hasConceptScore W2139848240C530470458 @default.
• W2139848240 hasConceptScore W2139848240C54355233 @default.
• W2139848240 hasConceptScore W2139848240C55493867 @default.
• W2139848240 hasConceptScore W2139848240C63932345 @default.
• W2139848240 hasConceptScore W2139848240C70721500 @default.
• W2139848240 hasConceptScore W2139848240C71315377 @default.
• W2139848240 hasConceptScore W2139848240C84606932 @default.
• W2139848240 hasConceptScore W2139848240C86339819 @default.
• W2139848240 hasConceptScore W2139848240C86803240 @default.
• W2139848240 hasIssue "2" @default.
• W2139848240 hasLocation W21398482401 @default.
• W2139848240 hasLocation W21398482402 @default.
• W2139848240 hasOpenAccess W2139848240 @default.
• W2139848240 hasPrimaryLocation W21398482401 @default.
• W2139848240 hasRelatedWork W1522503821 @default.
• W2139848240 hasRelatedWork W1982267339 @default.

• next