Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139849392> ?p ?o ?g. }
- W2139849392 endingPage "2345" @default.
- W2139849392 startingPage "2331" @default.
- W2139849392 abstract "In interphase cells, the adenomatous polyposis coli (APC) protein accumulates on a small subset of microtubules (MTs) in cell protrusions, suggesting that APC may regulate the dynamics of these MTs. We comicroinjected a nonperturbing fluorescently labeled monoclonal antibody and labeled tubulin to simultaneously visualize dynamics of endogenous APC and MTs in living cells. MTs decorated with APC spent more time growing and had a decreased catastrophe frequency compared with non-APC-decorated MTs. Endogenous APC associated briefly with shortening MTs. To determine the relationship between APC and its binding partner EB1, we monitored EB1-green fluorescent protein and endogenous APC concomitantly in living cells. Only a small fraction of EB1 colocalized with APC at any one time. APC-deficient cells and EB1 small interfering RNA showed that EB1 and APC localized at MT ends independently. Depletion of EB1 did not change the growth-stabilizing effects of APC on MT plus ends. In addition, APC remained bound to MTs stabilized with low nocodazole, whereas EB1 did not. Thus, we demonstrate that the association of endogenous APC with MT ends correlates directly with their increased growth stability, that this can occur independently of its association with EB1, and that APC and EB1 can associate with MT plus ends by distinct mechanisms." @default.
- W2139849392 created "2016-06-24" @default.
- W2139849392 creator A5003734971 @default.
- W2139849392 creator A5026554721 @default.
- W2139849392 creator A5050726856 @default.
- W2139849392 creator A5074176340 @default.
- W2139849392 date "2006-05-01" @default.
- W2139849392 modified "2023-09-23" @default.
- W2139849392 title "Adenomatous Polyposis Coli on Microtubule Plus Ends in Cell Extensions Can Promote Microtubule Net Growth with or without EB1" @default.
- W2139849392 cites W1546151374 @default.
- W2139849392 cites W1546492519 @default.
- W2139849392 cites W1564599503 @default.
- W2139849392 cites W1582072542 @default.
- W2139849392 cites W1593939420 @default.
- W2139849392 cites W1809606297 @default.
- W2139849392 cites W1950882148 @default.
- W2139849392 cites W1964606074 @default.
- W2139849392 cites W1966121721 @default.
- W2139849392 cites W1966584364 @default.
- W2139849392 cites W1967243795 @default.
- W2139849392 cites W1967921405 @default.
- W2139849392 cites W1975079427 @default.
- W2139849392 cites W1976971329 @default.
- W2139849392 cites W1978705545 @default.
- W2139849392 cites W1979618971 @default.
- W2139849392 cites W1984374880 @default.
- W2139849392 cites W1985499212 @default.
- W2139849392 cites W1987678786 @default.
- W2139849392 cites W1988136514 @default.
- W2139849392 cites W1994325330 @default.
- W2139849392 cites W1996982933 @default.
- W2139849392 cites W1998115472 @default.
- W2139849392 cites W1998170462 @default.
- W2139849392 cites W2001859337 @default.
- W2139849392 cites W2002858128 @default.
- W2139849392 cites W2003927439 @default.
- W2139849392 cites W2005900617 @default.
- W2139849392 cites W2010934863 @default.
- W2139849392 cites W2018516624 @default.
- W2139849392 cites W2021135236 @default.
- W2139849392 cites W2024349625 @default.
- W2139849392 cites W2030378751 @default.
- W2139849392 cites W2038325071 @default.
- W2139849392 cites W2038783205 @default.
- W2139849392 cites W2039661491 @default.
- W2139849392 cites W2045675250 @default.
- W2139849392 cites W2046420076 @default.
- W2139849392 cites W2050862757 @default.
- W2139849392 cites W2050998289 @default.
- W2139849392 cites W2054482640 @default.
- W2139849392 cites W2057351369 @default.
- W2139849392 cites W2062927800 @default.
- W2139849392 cites W2070275392 @default.
- W2139849392 cites W2072509928 @default.
- W2139849392 cites W2080184799 @default.
- W2139849392 cites W2080480789 @default.
- W2139849392 cites W2081012321 @default.
- W2139849392 cites W2081758458 @default.
- W2139849392 cites W2085252478 @default.
- W2139849392 cites W2091494325 @default.
- W2139849392 cites W2098250898 @default.
- W2139849392 cites W2100649932 @default.
- W2139849392 cites W2105512502 @default.
- W2139849392 cites W2113997447 @default.
- W2139849392 cites W2114252625 @default.
- W2139849392 cites W2121515452 @default.
- W2139849392 cites W2125538185 @default.
- W2139849392 cites W2130867962 @default.
- W2139849392 cites W2135715423 @default.
- W2139849392 cites W2136373114 @default.
- W2139849392 cites W2142508738 @default.
- W2139849392 cites W2148018436 @default.
- W2139849392 cites W2152515299 @default.
- W2139849392 cites W2158239169 @default.
- W2139849392 cites W2158977019 @default.
- W2139849392 cites W2164055070 @default.
- W2139849392 cites W2166722620 @default.
- W2139849392 cites W2167290154 @default.
- W2139849392 cites W2239090104 @default.
- W2139849392 cites W4231860297 @default.
- W2139849392 doi "https://doi.org/10.1091/mbc.e05-06-0498" @default.
- W2139849392 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1446093" @default.
- W2139849392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16525027" @default.
- W2139849392 hasPublicationYear "2006" @default.
- W2139849392 type Work @default.
- W2139849392 sameAs 2139849392 @default.
- W2139849392 citedByCount "107" @default.
- W2139849392 countsByYear W21398493922012 @default.
- W2139849392 countsByYear W21398493922013 @default.
- W2139849392 countsByYear W21398493922014 @default.
- W2139849392 countsByYear W21398493922015 @default.
- W2139849392 countsByYear W21398493922016 @default.
- W2139849392 countsByYear W21398493922017 @default.
- W2139849392 countsByYear W21398493922018 @default.
- W2139849392 countsByYear W21398493922019 @default.
- W2139849392 countsByYear W21398493922020 @default.
- W2139849392 countsByYear W21398493922021 @default.
- W2139849392 countsByYear W21398493922022 @default.