Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139903295> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2139903295 endingPage "54" @default.
- W2139903295 startingPage "51" @default.
- W2139903295 abstract "Male Sprague-Dawley rats received four consecutive intraperitoneal (i.p.) doses of five kinds of methylsulfonyl (MeSO2) metabolites of tetra- and pentachlorinated biphenyls (tetra- and pentaCBs) to determine their effects on thyroid hormone levels. The five MeSO2 metabolites, which were the major MeSO2-PCBs detected in human milk, liver and adipose tissue were 3-MeSO2-2,2',4',5-tetraCB (3-MeSO2-CB49),3-MeSO2-2,3',4',5-tetraCB (3-MeSO2-CB70), 3-MeSO2-2,2',3',4',5-pentaCB (3-MeSO2-CB87), 3-MeSO2-2,2',4',5,5'-pentaCB (3-MeSO2-CB101), and 4-MeSO2-2,2',4',5,5'-pentaCB (4-MeSO2-CB101). All five tested MeSO2 metabolites (20 mumol/kg once daily for 4 days) reduced serum total thyroxine levels 16-40% on days 2, 3, 4, and 7 (after the last dosage). The total triiodothyronine level was reduced 37% by treatment with 3-MeSO2-CB49 at day 7, but was increased 35% and 38% by 3-MeSO2-CB70 and 4-MeSO2-CB101 at days 3 and 4, respectively. The reductions in thyroid hormone levels led to an increase in thyroid stimulating hormone (TSH) levels by 3-MeSO2-CB49, 3-MeSO2-CB87 and 3-MeSO2-CB101. A 30% increase in thyroid weight was produced by 3-MeSO2-CB101 treatment. Thus, it is likely that all five tested MeSO2 metabolites could influence thyroid hormone metabolism. The results show that the tested 3- and 4-MeSO2 metabolites of tetra- and pentaCBs reduce thyroid hormone levels in rats, suggesting that the metabolites may act as endocrine-disrupters." @default.
- W2139903295 created "2016-06-24" @default.
- W2139903295 creator A5005325316 @default.
- W2139903295 creator A5029396685 @default.
- W2139903295 creator A5032791559 @default.
- W2139903295 creator A5049631324 @default.
- W2139903295 creator A5086448929 @default.
- W2139903295 creator A5086475824 @default.
- W2139903295 date "1999-03-01" @default.
- W2139903295 modified "2023-10-17" @default.
- W2139903295 title "Reduction of thyroid hormone levels by methylsulfonyl metabolites of tetra- and pentachlorinated biphenyls in male Sprague-Dawley rats" @default.
- W2139903295 cites W1973127043 @default.
- W2139903295 cites W1978056220 @default.
- W2139903295 cites W1980828731 @default.
- W2139903295 cites W1987603727 @default.
- W2139903295 cites W2006482940 @default.
- W2139903295 cites W2011648754 @default.
- W2139903295 cites W2025387044 @default.
- W2139903295 cites W2045210836 @default.
- W2139903295 cites W2045908866 @default.
- W2139903295 cites W2047712840 @default.
- W2139903295 cites W2059317989 @default.
- W2139903295 cites W2060435130 @default.
- W2139903295 cites W2064171974 @default.
- W2139903295 cites W2065896541 @default.
- W2139903295 cites W2066543257 @default.
- W2139903295 cites W2068040505 @default.
- W2139903295 cites W2068412357 @default.
- W2139903295 cites W2075455572 @default.
- W2139903295 cites W2077495154 @default.
- W2139903295 cites W2080054283 @default.
- W2139903295 cites W2116972344 @default.
- W2139903295 cites W2168716298 @default.
- W2139903295 cites W2330937035 @default.
- W2139903295 cites W2210637179 @default.
- W2139903295 doi "https://doi.org/10.1093/toxsci/48.1.51" @default.
- W2139903295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10330683" @default.
- W2139903295 hasPublicationYear "1999" @default.
- W2139903295 type Work @default.
- W2139903295 sameAs 2139903295 @default.
- W2139903295 citedByCount "34" @default.
- W2139903295 countsByYear W21399032952012 @default.
- W2139903295 countsByYear W21399032952013 @default.
- W2139903295 countsByYear W21399032952014 @default.
- W2139903295 countsByYear W21399032952015 @default.
- W2139903295 countsByYear W21399032952023 @default.
- W2139903295 crossrefType "journal-article" @default.
- W2139903295 hasAuthorship W2139903295A5005325316 @default.
- W2139903295 hasAuthorship W2139903295A5029396685 @default.
- W2139903295 hasAuthorship W2139903295A5032791559 @default.
- W2139903295 hasAuthorship W2139903295A5049631324 @default.
- W2139903295 hasAuthorship W2139903295A5086448929 @default.
- W2139903295 hasAuthorship W2139903295A5086475824 @default.
- W2139903295 hasBestOaLocation W21399032951 @default.
- W2139903295 hasConcept C126322002 @default.
- W2139903295 hasConcept C185592680 @default.
- W2139903295 hasConcept C2777477808 @default.
- W2139903295 hasConcept C2778288131 @default.
- W2139903295 hasConcept C526584372 @default.
- W2139903295 hasConcept C55493867 @default.
- W2139903295 hasConcept C71315377 @default.
- W2139903295 hasConcept C71924100 @default.
- W2139903295 hasConceptScore W2139903295C126322002 @default.
- W2139903295 hasConceptScore W2139903295C185592680 @default.
- W2139903295 hasConceptScore W2139903295C2777477808 @default.
- W2139903295 hasConceptScore W2139903295C2778288131 @default.
- W2139903295 hasConceptScore W2139903295C526584372 @default.
- W2139903295 hasConceptScore W2139903295C55493867 @default.
- W2139903295 hasConceptScore W2139903295C71315377 @default.
- W2139903295 hasConceptScore W2139903295C71924100 @default.
- W2139903295 hasIssue "1" @default.
- W2139903295 hasLocation W21399032951 @default.
- W2139903295 hasLocation W21399032952 @default.
- W2139903295 hasOpenAccess W2139903295 @default.
- W2139903295 hasPrimaryLocation W21399032951 @default.
- W2139903295 hasRelatedWork W165683302 @default.
- W2139903295 hasRelatedWork W1753739957 @default.
- W2139903295 hasRelatedWork W1970345979 @default.
- W2139903295 hasRelatedWork W2011282322 @default.
- W2139903295 hasRelatedWork W2024044986 @default.
- W2139903295 hasRelatedWork W2085913165 @default.
- W2139903295 hasRelatedWork W2133799251 @default.
- W2139903295 hasRelatedWork W2444221640 @default.
- W2139903295 hasRelatedWork W2748952813 @default.
- W2139903295 hasRelatedWork W2521903434 @default.
- W2139903295 hasVolume "48" @default.
- W2139903295 isParatext "false" @default.
- W2139903295 isRetracted "false" @default.
- W2139903295 magId "2139903295" @default.
- W2139903295 workType "article" @default.