Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139925886> ?p ?o ?g. }
Showing items 1 to 61 of
61
with 100 items per page.
- W2139925886 endingPage "2811" @default.
- W2139925886 startingPage "2809" @default.
- W2139925886 abstract "Physical training in myopathy: yes or no? This highlights a long-standing dilemma, and one that is still a matter of debate and controversy. Is it beneficial, at least to avoid muscle deconditioning, or detrimental, even harmful, because of the mechanical stress imposed to wrecked myofibres?An initial consideration is that little attention has been given to the different responses to training that the various myopathic conditions can produce. A second, consequential one, is that lack of unequivocal results and flaws in the training protocols let physicians take a somewhat empirical attitude—dictated by personal inclinations, common sense, indulgence toward patient compliance or just prudence inspired by ‘ primum non nocere - first do not harm’, an old evergreen precept (Hippocrates, 460–377 BC). In many cases, the final persuasion is that physical exercise is not recommended, through anxiety over the risk of damaging an already compromised muscle, or even triggering acute episodes of pain, rhabdomyolysis and myoglobinuria. The latter are certainly contraindications to strenuous physical exercise, for instance in several metabolic myopathies related to impaired energy metabolism, such as the lipid storage myopathies, due to defects of intra-mitochondrial transport and utilization of fatty acids (Bruno and DiMauro, 2008; e.g. carnitine-palmitoyl transferase II deficiency, electron transfer flavoprotein dehydrogenase (ETF-DH) deficiency, and very long-chain fatty acid β-oxidation defects) or glycogen (DiMauro, 2007; e.g. myophosphorylase deficiency and defects of intermediary glycolytic enzymes). Some defects of the mitochondrial respiratory chain are also associated with myoglobinuria, notably deficiency of CoQ10 (especially related to ETF-DH deficiency) and mutations in the MTCOB gene (Andreu et al. , 1999), but in most cases neither high creatine kinase nor myoglobinuric episodes are frequent symptoms of mitochondrial disorders.In addition, little, if any, attention is paid to the quantitative and qualitative features of therapeutic physical training (van der Kooi …" @default.
- W2139925886 created "2016-06-24" @default.
- W2139925886 creator A5048857899 @default.
- W2139925886 date "2008-06-21" @default.
- W2139925886 modified "2023-09-24" @default.
- W2139925886 title "Train, train, train! No pain, just gain" @default.
- W2139925886 cites W1967225780 @default.
- W2139925886 cites W1976393409 @default.
- W2139925886 cites W2000661220 @default.
- W2139925886 cites W2010476133 @default.
- W2139925886 cites W2065335605 @default.
- W2139925886 cites W2086369154 @default.
- W2139925886 cites W2086512618 @default.
- W2139925886 cites W2105375495 @default.
- W2139925886 cites W2413311099 @default.
- W2139925886 doi "https://doi.org/10.1093/brain/awn264" @default.
- W2139925886 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18971203" @default.
- W2139925886 hasPublicationYear "2008" @default.
- W2139925886 type Work @default.
- W2139925886 sameAs 2139925886 @default.
- W2139925886 citedByCount "19" @default.
- W2139925886 countsByYear W21399258862012 @default.
- W2139925886 countsByYear W21399258862015 @default.
- W2139925886 countsByYear W21399258862018 @default.
- W2139925886 countsByYear W21399258862019 @default.
- W2139925886 countsByYear W21399258862021 @default.
- W2139925886 countsByYear W21399258862022 @default.
- W2139925886 countsByYear W21399258862023 @default.
- W2139925886 crossrefType "journal-article" @default.
- W2139925886 hasAuthorship W2139925886A5048857899 @default.
- W2139925886 hasBestOaLocation W21399258861 @default.
- W2139925886 hasConcept C15744967 @default.
- W2139925886 hasConcept C169760540 @default.
- W2139925886 hasConcept C71924100 @default.
- W2139925886 hasConcept C99508421 @default.
- W2139925886 hasConceptScore W2139925886C15744967 @default.
- W2139925886 hasConceptScore W2139925886C169760540 @default.
- W2139925886 hasConceptScore W2139925886C71924100 @default.
- W2139925886 hasConceptScore W2139925886C99508421 @default.
- W2139925886 hasIssue "11" @default.
- W2139925886 hasLocation W21399258861 @default.
- W2139925886 hasLocation W21399258862 @default.
- W2139925886 hasOpenAccess W2139925886 @default.
- W2139925886 hasPrimaryLocation W21399258861 @default.
- W2139925886 hasRelatedWork W1506200166 @default.
- W2139925886 hasRelatedWork W1995515455 @default.
- W2139925886 hasRelatedWork W2048182022 @default.
- W2139925886 hasRelatedWork W2080531066 @default.
- W2139925886 hasRelatedWork W2604872355 @default.
- W2139925886 hasRelatedWork W2748952813 @default.
- W2139925886 hasRelatedWork W2899084033 @default.
- W2139925886 hasRelatedWork W3031052312 @default.
- W2139925886 hasRelatedWork W3032375762 @default.
- W2139925886 hasRelatedWork W3108674512 @default.
- W2139925886 hasVolume "131" @default.
- W2139925886 isParatext "false" @default.
- W2139925886 isRetracted "false" @default.
- W2139925886 magId "2139925886" @default.
- W2139925886 workType "article" @default.