FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139934144> ?p ?o ?g. }

• W2139934144 endingPage "7319" @default.
• W2139934144 startingPage "7307" @default.
• W2139934144 abstract "Nascent pre-mRNAs associate with hnRNP proteins in hnRNP complexes, the natural substrates for mRNA processing. Several lines of evidence indicate that hnRNP complexes undergo substantial remodeling during mRNA formation and export. Here we report the isolation of three distinct types of pre-mRNP and mRNP complexes from HeLa cells associated with hnRNP A1, a shuttling hnRNP protein. Based on their RNA and protein compositions, these complexes are likely to represent distinct stages in the nucleocytoplasmic shuttling pathway of hnRNP A1 with its bound RNAs. In the cytoplasm, A1 is associated with its nuclear import receptor (transportin), the cytoplasmic poly(A)-binding protein, and mRNA. In the nucleus, A1 is found in two distinct types of complexes that are differently associated with nuclear structures. One class contains pre-mRNA and mRNA and is identical to previously described hnRNP complexes. The other class behaves as freely diffusible nuclear mRNPs (nmRNPs) at late nuclear stages of maturation and possibly associated with nuclear mRNA export. These nmRNPs differ from hnRNPs in that while they contain shuttling hnRNP proteins, the mRNA export factor REF, and mRNA, they do not contain nonshuttling hnRNP proteins or pre-mRNA. Importantly, nmRNPs also contain proteins not found in hnRNP complexes. These include the alternatively spliced isoforms D01 and D02 of the hnRNP D proteins, the E0 isoform of the hnRNP E proteins, and LRP130, a previously reported protein with unknown function that appears to have a novel type of RNA-binding domain. The characteristics of these complexes indicate that they result from RNP remodeling associated with mRNA maturation and delineate specific changes in RNP protein composition during formation and transport of mRNA in vivo." @default.
• W2139934144 created "2016-06-24" @default.
• W2139934144 creator A5021547370 @default.
• W2139934144 creator A5033655738 @default.
• W2139934144 creator A5074957423 @default.
• W2139934144 creator A5080654910 @default.
• W2139934144 date "2001-11-01" @default.
• W2139934144 modified "2023-10-15" @default.
• W2139934144 title "Distinct RNP Complexes of Shuttling hnRNP Proteins with Pre-mRNA and mRNA: Candidate Intermediates in Formation and Export of mRNA" @default.
• W2139934144 cites W1044509411 @default.
• W2139934144 cites W1508541438 @default.
• W2139934144 cites W1881953678 @default.
• W2139934144 cites W1967554461 @default.
• W2139934144 cites W1968518926 @default.
• W2139934144 cites W1971396838 @default.
• W2139934144 cites W1973052124 @default.
• W2139934144 cites W1975353293 @default.
• W2139934144 cites W1983315505 @default.
• W2139934144 cites W1991560045 @default.
• W2139934144 cites W1994778192 @default.
• W2139934144 cites W1995567382 @default.
• W2139934144 cites W2000159925 @default.
• W2139934144 cites W2001323818 @default.
• W2139934144 cites W2005100774 @default.
• W2139934144 cites W2006301581 @default.
• W2139934144 cites W2006595758 @default.
• W2139934144 cites W2008837951 @default.
• W2139934144 cites W2009207482 @default.
• W2139934144 cites W2015775176 @default.
• W2139934144 cites W2016493017 @default.
• W2139934144 cites W2021026930 @default.
• W2139934144 cites W2022445608 @default.
• W2139934144 cites W2027593556 @default.
• W2139934144 cites W2030400204 @default.
• W2139934144 cites W2030810484 @default.
• W2139934144 cites W2033680770 @default.
• W2139934144 cites W2036748891 @default.
• W2139934144 cites W2037094815 @default.
• W2139934144 cites W2037534409 @default.
• W2139934144 cites W2043590887 @default.
• W2139934144 cites W2043627932 @default.
• W2139934144 cites W2046634234 @default.
• W2139934144 cites W2050324319 @default.
• W2139934144 cites W2051948296 @default.
• W2139934144 cites W2065868028 @default.
• W2139934144 cites W2067648564 @default.
• W2139934144 cites W2076300996 @default.
• W2139934144 cites W2077543321 @default.
• W2139934144 cites W2080489609 @default.
• W2139934144 cites W2082183799 @default.
• W2139934144 cites W2083340704 @default.
• W2139934144 cites W2083420802 @default.
• W2139934144 cites W2083453910 @default.
• W2139934144 cites W2085245358 @default.
• W2139934144 cites W2091856409 @default.
• W2139934144 cites W2093842915 @default.
• W2139934144 cites W2095390159 @default.
• W2139934144 cites W2100559753 @default.
• W2139934144 cites W2101679570 @default.
• W2139934144 cites W2109846882 @default.
• W2139934144 cites W2110722621 @default.
• W2139934144 cites W2113954150 @default.
• W2139934144 cites W2116711309 @default.
• W2139934144 cites W2120372693 @default.
• W2139934144 cites W2122656626 @default.
• W2139934144 cites W2127255834 @default.
• W2139934144 cites W2127534226 @default.
• W2139934144 cites W2127901995 @default.
• W2139934144 cites W2129206486 @default.
• W2139934144 cites W2137990405 @default.
• W2139934144 cites W2138459463 @default.
• W2139934144 cites W2138647063 @default.
• W2139934144 cites W2141238215 @default.
• W2139934144 cites W2143566830 @default.
• W2139934144 cites W2143814486 @default.
• W2139934144 cites W2146702776 @default.
• W2139934144 cites W2152957900 @default.
• W2139934144 cites W2153405631 @default.
• W2139934144 cites W2154222508 @default.
• W2139934144 cites W2158714788 @default.
• W2139934144 cites W2159391740 @default.
• W2139934144 cites W2163765191 @default.
• W2139934144 cites W2164588795 @default.
• W2139934144 cites W2167635085 @default.
• W2139934144 cites W2168336539 @default.
• W2139934144 cites W2316437833 @default.
• W2139934144 cites W4240115127 @default.
• W2139934144 doi "https://doi.org/10.1128/mcb.21.21.7307-7319.2001" @default.
• W2139934144 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/99905" @default.
• W2139934144 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11585913" @default.
• W2139934144 hasPublicationYear "2001" @default.
• W2139934144 type Work @default.
• W2139934144 sameAs 2139934144 @default.
• W2139934144 citedByCount "145" @default.
• W2139934144 countsByYear W21399341442012 @default.
• W2139934144 countsByYear W21399341442013 @default.
• W2139934144 countsByYear W21399341442014 @default.
• W2139934144 countsByYear W21399341442015 @default.

• next