FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139968275> ?p ?o ?g. }

• W2139968275 endingPage "7282" @default.
• W2139968275 startingPage "7271" @default.
• W2139968275 abstract "Apigenin, a flavonoid commonly present in the daily diet, is known for its potential anti-tumor properties. However, the effect of apigenin via oral administration on tumor growth and metastasis remains unknown. In this study we developed an orthotopic ovarian tumor model in nude mice to test the effect of apigenin oral administration, and showed that apigenin inhibited the micrometastasis of cancer cells in the animal tumor model. To understand the mechanism of apigenin in inhibiting metastasis, we found that apigenin greatly inhibited MMP-9 expression and p-AKT and p-p70S6K1 levels in the tumor tissues compared to the control group. We further demonstrated that the downregulation of MMP-9 by apigenin was mediated by the AKT/p70S6K1 pathway. These findings help to address the question with common interests to the public of whether oral uptake of flavonoids is effective in preventing cancer. Our results demonstrate for the first time that oral uptake of apigenin can inhibit tumor metastasis through MMP-9 expression using the orthotopic ovarian tumor model." @default.
• W2139968275 created "2016-06-24" @default.
• W2139968275 creator A5015102287 @default.
• W2139968275 creator A5019709322 @default.
• W2139968275 creator A5053401529 @default.
• W2139968275 creator A5054807427 @default.
• W2139968275 creator A5055653838 @default.
• W2139968275 creator A5058772864 @default.
• W2139968275 creator A5065023946 @default.
• W2139968275 creator A5081687805 @default.
• W2139968275 date "2012-06-13" @default.
• W2139968275 modified "2023-10-16" @default.
• W2139968275 title "Oral Administration of Apigenin Inhibits Metastasis through AKT/P70S6K1/MMP-9 Pathway in Orthotopic Ovarian Tumor Model" @default.
• W2139968275 cites W1592927823 @default.
• W2139968275 cites W1886431664 @default.
• W2139968275 cites W1893341441 @default.
• W2139968275 cites W1911262314 @default.
• W2139968275 cites W1995493762 @default.
• W2139968275 cites W1997559135 @default.
• W2139968275 cites W2005786362 @default.
• W2139968275 cites W2041602966 @default.
• W2139968275 cites W2041749013 @default.
• W2139968275 cites W2051202261 @default.
• W2139968275 cites W2052728502 @default.
• W2139968275 cites W2082384599 @default.
• W2139968275 cites W2100275705 @default.
• W2139968275 cites W2132772974 @default.
• W2139968275 cites W2142325703 @default.
• W2139968275 cites W2153863159 @default.
• W2139968275 cites W2468784059 @default.
• W2139968275 cites W332390835 @default.
• W2139968275 cites W90697117 @default.
• W2139968275 doi "https://doi.org/10.3390/ijms13067271" @default.
• W2139968275 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3397525" @default.
• W2139968275 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22837693" @default.
• W2139968275 hasPublicationYear "2012" @default.
• W2139968275 type Work @default.
• W2139968275 sameAs 2139968275 @default.
• W2139968275 citedByCount "40" @default.
• W2139968275 countsByYear W21399682752013 @default.
• W2139968275 countsByYear W21399682752014 @default.
• W2139968275 countsByYear W21399682752015 @default.
• W2139968275 countsByYear W21399682752016 @default.
• W2139968275 countsByYear W21399682752017 @default.
• W2139968275 countsByYear W21399682752018 @default.
• W2139968275 countsByYear W21399682752019 @default.
• W2139968275 countsByYear W21399682752020 @default.
• W2139968275 countsByYear W21399682752021 @default.
• W2139968275 countsByYear W21399682752022 @default.
• W2139968275 countsByYear W21399682752023 @default.
• W2139968275 crossrefType "journal-article" @default.
• W2139968275 hasAuthorship W2139968275A5015102287 @default.
• W2139968275 hasAuthorship W2139968275A5019709322 @default.
• W2139968275 hasAuthorship W2139968275A5053401529 @default.
• W2139968275 hasAuthorship W2139968275A5054807427 @default.
• W2139968275 hasAuthorship W2139968275A5055653838 @default.
• W2139968275 hasAuthorship W2139968275A5058772864 @default.
• W2139968275 hasAuthorship W2139968275A5065023946 @default.
• W2139968275 hasAuthorship W2139968275A5081687805 @default.
• W2139968275 hasBestOaLocation W21399682751 @default.
• W2139968275 hasConcept C121608353 @default.
• W2139968275 hasConcept C126322002 @default.
• W2139968275 hasConcept C185592680 @default.
• W2139968275 hasConcept C2777056448 @default.
• W2139968275 hasConcept C2778004101 @default.
• W2139968275 hasConcept C2778609962 @default.
• W2139968275 hasConcept C2779013556 @default.
• W2139968275 hasConcept C2779054382 @default.
• W2139968275 hasConcept C2779256057 @default.
• W2139968275 hasConcept C2780427987 @default.
• W2139968275 hasConcept C502942594 @default.
• W2139968275 hasConcept C55493867 @default.
• W2139968275 hasConcept C62478195 @default.
• W2139968275 hasConcept C71924100 @default.
• W2139968275 hasConcept C75217442 @default.
• W2139968275 hasConcept C98274493 @default.
• W2139968275 hasConceptScore W2139968275C121608353 @default.
• W2139968275 hasConceptScore W2139968275C126322002 @default.
• W2139968275 hasConceptScore W2139968275C185592680 @default.
• W2139968275 hasConceptScore W2139968275C2777056448 @default.
• W2139968275 hasConceptScore W2139968275C2778004101 @default.
• W2139968275 hasConceptScore W2139968275C2778609962 @default.
• W2139968275 hasConceptScore W2139968275C2779013556 @default.
• W2139968275 hasConceptScore W2139968275C2779054382 @default.
• W2139968275 hasConceptScore W2139968275C2779256057 @default.
• W2139968275 hasConceptScore W2139968275C2780427987 @default.
• W2139968275 hasConceptScore W2139968275C502942594 @default.
• W2139968275 hasConceptScore W2139968275C55493867 @default.
• W2139968275 hasConceptScore W2139968275C62478195 @default.
• W2139968275 hasConceptScore W2139968275C71924100 @default.
• W2139968275 hasConceptScore W2139968275C75217442 @default.
• W2139968275 hasConceptScore W2139968275C98274493 @default.
• W2139968275 hasIssue "6" @default.
• W2139968275 hasLocation W21399682751 @default.
• W2139968275 hasLocation W21399682752 @default.
• W2139968275 hasLocation W21399682753 @default.
• W2139968275 hasLocation W21399682754 @default.
• W2139968275 hasLocation W21399682755 @default.

• next