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• W2139968369 abstract "Bovine macrophage-derived tumour necrosis factor-alpha/ cachectin (TNF-α) was synthesized when peripheral blood mononuclear cells (PBMC) and purified adherent PBMC from naïve and Theileria annulata-infected cattle were incubated in vitro with concanavalin A (Con-A) or bovine recombinant interferon gamma (Bo rIFN-γ). TNF-α production was also induced when adherent PBMC were cultured with T. annulata macroschizont-infected cells. In contrast, non-adherent PBMC from sublethally infected cattle produced interferon (IFN) when incubated with Hu rIL-2, Con-A, phytohaemagglutinin (PHA) or T. annulata macroschizont-infected cells growing as cell lines in vitro. Whilst PBMC from lethally infected cattle spontaneously produced IFN-γ during advanced stages of infection, the sera of such animals contained type 1 IFN (alpha/beta). IFN was also produced by T. annulata macroschizont-infected cell lines maintained in vitro. This work suggests that cytokines serve as crucial links between proliferating Theileira-infected cells and the characteristic clinical symptoms of tropical theileriosis." @default.
• W2139968369 created "2016-06-24" @default.
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• W2139968369 date "1993-09-01" @default.
• W2139968369 modified "2023-09-23" @default.
• W2139968369 title "Synthesis of tumour necrosis factor-alpha and interferons by mononuclear cells from Theileria annulata-infected cattle" @default.
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• W2139968369 doi "https://doi.org/10.1111/j.1365-3024.1993.tb00640.x" @default.
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