FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139968509> ?p ?o ?g. }

• W2139968509 abstract "Neurogenesis - the generation of new neurons - is an ongoing process that persists in the adult mammalian brain of several species, including humans. In this work we analyze two discrete brain regions: the subventricular zone (SVZ) lining the walls of the lateral ventricles; and the subgranular zone (SGZ) of the dentate gyrus of the hippocampus in mice and shed light on the SVZ and SGZ specific neurogenesis. We propose a computational model that relies on the construction and analysis of region specific gene regulatory networks from the publicly available data on these two regions. Using this model a number of putative factors involved in neuronal stem cell (NSC) identity and maintenance were identified. We also demonstrate potential gender and niche-derived differences based on cell surface and nuclear receptors via Ar, Hif1a and Nr3c1. We have also conducted cell fate determinant analysis for SVZ NSC populations to Olfactory Bulb interneurons and SGZ NSC populations to the granule cells of the Granular Cell Layer. We report thirty-one candidate cell fate determinant gene pairs, ready to be validated. We focus on Ar - Pax6 in SVZ and Sox2 - Ncor1 in SGZ. Both pairs are expressed and localized in the suggested anatomical structures as shown by in situ hybridization and found to physically interact. Finally, we conclude that there are fundamental differences between SGZ and SVZ neurogenesis. We argue that these regulatory mechanisms are linked to the observed differential neurogenic potential of these regions. The presence of nuclear and cell surface receptors in the region specific regulatory circuits indicate the significance of niche derived extracellular factors, hormones and region specific factors such as the oxygen sensitivity, dictating SGZ and SVZ specific neurogenesis." @default.
• W2139968509 created "2016-06-24" @default.
• W2139968509 creator A5036136107 @default.
• W2139968509 creator A5061805930 @default.
• W2139968509 creator A5075664103 @default.
• W2139968509 creator A5082614669 @default.
• W2139968509 date "2014-12-18" @default.
• W2139968509 modified "2023-09-27" @default.
• W2139968509 title "Gene regulatory network analysis reveals differences in site-specific cell fate determination in mammalian brain" @default.
• W2139968509 cites W1592283056 @default.
• W2139968509 cites W1611895582 @default.
• W2139968509 cites W1643680178 @default.
• W2139968509 cites W1859730138 @default.
• W2139968509 cites W1968242213 @default.
• W2139968509 cites W1968461724 @default.
• W2139968509 cites W1972928390 @default.
• W2139968509 cites W1980499453 @default.
• W2139968509 cites W1981203912 @default.
• W2139968509 cites W1983955843 @default.
• W2139968509 cites W1988210171 @default.
• W2139968509 cites W1990044878 @default.
• W2139968509 cites W1995145561 @default.
• W2139968509 cites W2003982930 @default.
• W2139968509 cites W2004588076 @default.
• W2139968509 cites W2007095775 @default.
• W2139968509 cites W2014386715 @default.
• W2139968509 cites W2016486388 @default.
• W2139968509 cites W2016987246 @default.
• W2139968509 cites W2018151311 @default.
• W2139968509 cites W2020541351 @default.
• W2139968509 cites W2021130838 @default.
• W2139968509 cites W2025034737 @default.
• W2139968509 cites W2026599973 @default.
• W2139968509 cites W2029991507 @default.
• W2139968509 cites W2031407988 @default.
• W2139968509 cites W2034528919 @default.
• W2139968509 cites W2043772793 @default.
• W2139968509 cites W2044103334 @default.
• W2139968509 cites W2046157151 @default.
• W2139968509 cites W2048398100 @default.
• W2139968509 cites W2050054329 @default.
• W2139968509 cites W2051021067 @default.
• W2139968509 cites W2059201000 @default.
• W2139968509 cites W2059366905 @default.
• W2139968509 cites W2071807983 @default.
• W2139968509 cites W2073005183 @default.
• W2139968509 cites W2073471495 @default.
• W2139968509 cites W2077439063 @default.
• W2139968509 cites W2077599130 @default.
• W2139968509 cites W2078909337 @default.
• W2139968509 cites W2084402047 @default.
• W2139968509 cites W2084652820 @default.
• W2139968509 cites W2088973714 @default.
• W2139968509 cites W2089204174 @default.
• W2139968509 cites W2090137827 @default.
• W2139968509 cites W2094065018 @default.
• W2139968509 cites W2099035230 @default.
• W2139968509 cites W2100566978 @default.
• W2139968509 cites W2105665255 @default.
• W2139968509 cites W2109261272 @default.
• W2139968509 cites W2109838864 @default.
• W2139968509 cites W2111676921 @default.
• W2139968509 cites W2117523148 @default.
• W2139968509 cites W2120865735 @default.
• W2139968509 cites W2121147886 @default.
• W2139968509 cites W2124134886 @default.
• W2139968509 cites W2127878701 @default.
• W2139968509 cites W2135857985 @default.
• W2139968509 cites W2137279272 @default.
• W2139968509 cites W2140815401 @default.
• W2139968509 cites W2142096644 @default.
• W2139968509 cites W2146417573 @default.
• W2139968509 cites W2148856565 @default.
• W2139968509 cites W2149821525 @default.
• W2139968509 cites W2153122353 @default.
• W2139968509 cites W2155639900 @default.
• W2139968509 cites W2159559130 @default.
• W2139968509 cites W2159675211 @default.
• W2139968509 cites W2160699408 @default.
• W2139968509 cites W2162502065 @default.
• W2139968509 cites W2165224884 @default.
• W2139968509 cites W2165867905 @default.
• W2139968509 cites W2166261688 @default.
• W2139968509 cites W2171297629 @default.
• W2139968509 cites W2172266256 @default.
• W2139968509 cites W2320983896 @default.
• W2139968509 doi "https://doi.org/10.3389/fncel.2014.00437" @default.
• W2139968509 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4270183" @default.
• W2139968509 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25565969" @default.
• W2139968509 hasPublicationYear "2014" @default.
• W2139968509 type Work @default.
• W2139968509 sameAs 2139968509 @default.
• W2139968509 citedByCount "15" @default.
• W2139968509 countsByYear W21399685092015 @default.
• W2139968509 countsByYear W21399685092016 @default.
• W2139968509 countsByYear W21399685092017 @default.
• W2139968509 countsByYear W21399685092018 @default.
• W2139968509 countsByYear W21399685092020 @default.
• W2139968509 countsByYear W21399685092022 @default.
• W2139968509 crossrefType "journal-article" @default.

• next