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- W2139968600 abstract "From the very early days of Carrel’s experimental attempts at transplantation in the 1900s resulting in the Nobel Prize of 1912 [1], to the unimmunosuppressed allografting of the 1950s and the slightly more successful outcome of twin-totwin transplants [2], the road to what we now regard as an almost routine and successful operation was indeed paved with multiple pitfalls, leaving some groups, at the time, to wonder whether further work in this area was justified. It was not until a better understanding of tissue rejection and the introduction of azathioprine and steroid in 1963 [3], and more specifically Cyclosporin A by Calne in the 1970s [4], that the door to progress was fully opened. Improvements in surgical technique, newer, more effective and less toxic anti-rejection therapy, the routine use of ultrasound in the 1970s and Doppler a decade later, and the development of interventional radiology have all combined in a synergistic manner to make this the successful operation and clinical outcome, we now take so much for granted. Without the fortitude and dedication of these early pioneers however, it is unlikely that any of these advances would have ever been achieved. Much of the work described below is largely as a result of those early informative years." @default.
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- W2139968600 date "2002-08-01" @default.
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- W2139968600 title "Imaging and renal transplantation" @default.
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