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• W2139969213 startingPage "R9" @default.
• W2139969213 abstract "Each human has approximately 50 to 280 frameshifting indels, yet their implications are unknown. We created SIFT Indel, a prediction method for frameshifting indels that has 84% accuracy. The percentage of human frameshifting indels predicted to be gene-damaging is negatively correlated with allele frequency. We also show that although the first frameshifting indel in a gene causes loss of function, there is a tendency for the second frameshifting indel to compensate and restore protein function. SIFT Indel is available at http://sift-dna.org/www/SIFT_indels2.html" @default.
• W2139969213 created "2016-06-24" @default.
• W2139969213 creator A5003645187 @default.
• W2139969213 creator A5050031352 @default.
• W2139969213 date "2012-01-01" @default.
• W2139969213 modified "2023-09-27" @default.
• W2139969213 title "Predicting the effects of frameshifting indels" @default.
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• W2139969213 doi "https://doi.org/10.1186/gb-2012-13-2-r9" @default.
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