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- W2139986036 abstract "Lin, Y. S., and Y. R. Kou. Reflex apneic response evoked by laryngeal exposure to wood smoke in rats: neural and chemical mechanisms. J. Appl. Physiol. 83(3): 723–730, 1997.—We investigated the neural and chemical mechanisms contributing to the immediate ventilatory responses to laryngeal exposure to wood smoke in anesthetized Sprague-Dawley rats. Five milliliters of wood smoke were delivered into a functionally isolated larynx at a constant flow rate of 1.4 ml/s while the animals breathed spontaneously. Within 1 s after exposure, laryngeal wood smoke consistently triggered an apnea in each of the 42 rats tested. The apneic duration reached 1,636.4 ± 105.4 (SE) % ( n = 42) of the baseline expiratory duration. This apneic response was not affected by denervation of recurrent laryngeal nerves ( n = 6) or by removal of smoke particulates ( n = 14), but it was totally eliminated by topical application of an anesthetic ( n = 8; lidocaine hydrochloride, 8%) to the laryngeal mucosa or by sectioning of the superior laryngeal nerves ( n = 42). Furthermore, laryngeal application of a hydroxyl radical scavenger (dimethylthiourea; 500 mg/ml; n = 8) greatly diminished or abolished the smoke-induced apneic response, but it did not affect the apneic response evoked by laryngeal exposure to air saturated with 6% ammonia. These results suggest that the immediate apneic response to laryngeal wood smoke is a reflex resulting from the stimulation of the superior laryngeal afferents by the gas phase of wood smoke and that the stimulation is mediated through a hydroxyl radical mechanism." @default.
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- W2139986036 date "1997-09-01" @default.
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- W2139986036 title "Reflex apneic response evoked by laryngeal exposure to wood smoke in rats: neural and chemical mechanisms" @default.
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- W2139986036 doi "https://doi.org/10.1152/jappl.1997.83.3.723" @default.
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