Matches in SemOpenAlex for { <https://semopenalex.org/work/W2139986237> ?p ?o ?g. }
- W2139986237 endingPage "149" @default.
- W2139986237 startingPage "95" @default.
- W2139986237 abstract "The first models of translation described protein synthesis in terms of two operationally defined tRNA binding sites, the P-site for the donor substrate, the peptidyl-tRNA, and the A-site for the acceptor substrates, the aminoacyl-tRNAs. The discovery and analysis of the third tRNA binding site, the E-site specific for deacylated tRNAs, resulted in the allosteric three-site model, the two major features of which are (1) the reciprocal relationship of A-site and E-site occupation, and (2) simultaneous codon-anticodon interactions of both tRNAs present at the elongating ribosome. However, structural studies do not support the three operationally defined sites in a simple fashion as three topographically fixed entities, thus leading to new concepts of tRNA binding and movement: (1) the hybrid-site model describes the tRNAs' movement through the ribosome in terms of changing binding sites on the 30S and 50S subunits in an alternating fashion. The tRNAs thereby pass through hybrid binding states. (2) The alpha-epsilon model introduces the concept of a movable tRNA-binding domain comprising two binding sites, termed alpha and epsilon. The translocation movement is seen as a result of a conformational change of the ribosome rather than as a diffusion process between fixed binding sites. The alpha-epsilon model reconciles most of the experimental data currently available." @default.
- W2139986237 created "2016-06-24" @default.
- W2139986237 creator A5042033531 @default.
- W2139986237 creator A5047280151 @default.
- W2139986237 creator A5068634605 @default.
- W2139986237 creator A5074276510 @default.
- W2139986237 date "1998-01-01" @default.
- W2139986237 modified "2023-09-26" @default.
- W2139986237 title "Ribosomal tRNA Binding Sites: Three-Site Models of Translation" @default.
- W2139986237 cites W113094972 @default.
- W2139986237 cites W1241879706 @default.
- W2139986237 cites W1267732319 @default.
- W2139986237 cites W1497758287 @default.
- W2139986237 cites W1498217422 @default.
- W2139986237 cites W1512461236 @default.
- W2139986237 cites W1515771519 @default.
- W2139986237 cites W1517815992 @default.
- W2139986237 cites W1526493499 @default.
- W2139986237 cites W1529939061 @default.
- W2139986237 cites W1538351800 @default.
- W2139986237 cites W1551894200 @default.
- W2139986237 cites W1561212018 @default.
- W2139986237 cites W1569056628 @default.
- W2139986237 cites W1580190049 @default.
- W2139986237 cites W1589944020 @default.
- W2139986237 cites W1592933169 @default.
- W2139986237 cites W1606823119 @default.
- W2139986237 cites W164177113 @default.
- W2139986237 cites W1746621838 @default.
- W2139986237 cites W17901134 @default.
- W2139986237 cites W1900788388 @default.
- W2139986237 cites W1964075749 @default.
- W2139986237 cites W1967977918 @default.
- W2139986237 cites W1968951152 @default.
- W2139986237 cites W1969647089 @default.
- W2139986237 cites W1970107043 @default.
- W2139986237 cites W1974100775 @default.
- W2139986237 cites W1974452426 @default.
- W2139986237 cites W1979041400 @default.
- W2139986237 cites W1980325109 @default.
- W2139986237 cites W1980365471 @default.
- W2139986237 cites W1981533067 @default.
- W2139986237 cites W1982068343 @default.
- W2139986237 cites W1983593096 @default.
- W2139986237 cites W1984884697 @default.
- W2139986237 cites W1986737855 @default.
- W2139986237 cites W1989071971 @default.
- W2139986237 cites W1993124128 @default.
- W2139986237 cites W1993797831 @default.
- W2139986237 cites W1993818423 @default.
- W2139986237 cites W1994663143 @default.
- W2139986237 cites W1995418797 @default.
- W2139986237 cites W1997293906 @default.
- W2139986237 cites W1997581772 @default.
- W2139986237 cites W1997874208 @default.
- W2139986237 cites W199935964 @default.
- W2139986237 cites W1999652589 @default.
- W2139986237 cites W2000064612 @default.
- W2139986237 cites W2000088431 @default.
- W2139986237 cites W2001949118 @default.
- W2139986237 cites W2003252418 @default.
- W2139986237 cites W2003619147 @default.
- W2139986237 cites W2003669397 @default.
- W2139986237 cites W2003879700 @default.
- W2139986237 cites W2004087135 @default.
- W2139986237 cites W2006960379 @default.
- W2139986237 cites W2008014219 @default.
- W2139986237 cites W2010948386 @default.
- W2139986237 cites W2013303604 @default.
- W2139986237 cites W2015458141 @default.
- W2139986237 cites W2015729337 @default.
- W2139986237 cites W2016001703 @default.
- W2139986237 cites W2016684364 @default.
- W2139986237 cites W2017101101 @default.
- W2139986237 cites W2021761289 @default.
- W2139986237 cites W2023494525 @default.
- W2139986237 cites W2025313396 @default.
- W2139986237 cites W2025993658 @default.
- W2139986237 cites W2026358434 @default.
- W2139986237 cites W2028599803 @default.
- W2139986237 cites W2029249249 @default.
- W2139986237 cites W2032185255 @default.
- W2139986237 cites W2034353201 @default.
- W2139986237 cites W2036677254 @default.
- W2139986237 cites W2037339623 @default.
- W2139986237 cites W2039983396 @default.
- W2139986237 cites W2045434091 @default.
- W2139986237 cites W2046858308 @default.
- W2139986237 cites W2049193281 @default.
- W2139986237 cites W2050952012 @default.
- W2139986237 cites W2051162346 @default.
- W2139986237 cites W2051343195 @default.
- W2139986237 cites W2051479521 @default.
- W2139986237 cites W2051531395 @default.
- W2139986237 cites W2052163027 @default.
- W2139986237 cites W2054766951 @default.
- W2139986237 cites W2056059343 @default.
- W2139986237 cites W2057183734 @default.