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- W2139999862 abstract "The relationship between preoperative left ventricular (LV) dysfunction and the use of α-adrenoceptor agonists during weaning from cardiopulmonary bypass was studied in 102 patients undergoing coronary artery surgery. LV function was evaluated subjectively by examination of the 30° right anterior oblique left ventriculogram. Group 1 consisted of 75 patients with normal or mild impairment in LV function, whereas group 2 consisted of 27 patients with moderate-severe LV dysfunction. Cardiovascular parameters were measured at baseline, during hypothermic bypass with the aorta clamped, during normothermic bypass after unclamping, and 1 and 15 minutes after separation from bypass. Thirty-seven patients in group 1 (49%) and 11 patients in group 2 (39%) required some form of inotropic and/or vasopressor support during weaning from bypass. Group 2 required significantly higher cumulative doses of phenylephrine after bypass compared with group 1 (1.69 ± 0.70 mg, n = 9, v 0.24 ± 0.04 mg. n = 27, P < 0.05). Similarly, the dose of norepinephrine infusion in group 2 was 3.3 times that in group 1 (10 ± 6 μg/min, n = 2, v 3 ± 0.6 μg/min, n = 2, P = NS). The higher doses of α-adrenoceptor agonists required in patients with moderate-severe LV dysfunction may be due to differences in α-adrenoceptor agonist affinity and/or receptor density." @default.
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- W2139999862 date "1990-12-01" @default.
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- W2139999862 title "α-Adrenergic agonist drugs, left ventricular function, and emergence from cardiopulmonary bypass" @default.
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- W2139999862 doi "https://doi.org/10.1016/s0888-6296(09)90004-7" @default.
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