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• W2140014485 abstract "Methylation is a prevalent posttranscriptional modification of RNAs. However, whether mammalian microRNAs are methylated is unknown. Here, we show that the tRNA methyltransferase NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo. Methylation by NSun2 inhibits the processing of pri-miR-125b2 into pre-miR-125b2, decreases the cleavage of pre-miR-125b2 into miR-125, and attenuates the recruitment of RISC by miR-125, thereby repressing the function of miR-125b in silencing gene expression. Our results highlight the impact of miR-125b function via methylation by NSun2." @default.
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• W2140014485 date "2014-10-01" @default.
• W2140014485 modified "2023-10-11" @default.
• W2140014485 title "Methylation by NSun2 Represses the Levels and Function of MicroRNA 125b" @default.
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• W2140014485 doi "https://doi.org/10.1128/mcb.00243-14" @default.
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