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• W2140054852 abstract "The acyl carrier protein (ACP) from fatty acid synthases sequesters elongating products within its hydrophobic core, but this dynamic mechanism remains poorly understood. We exploited solvatochromic pantetheine probes attached to ACP that fluoresce when sequestered. The addition of a catalytic partner lures the cargo out of the ACP and into the active site of the enzyme, thus enhancing fluorescence to reveal the elusive chain-flipping mechanism. This activity was confirmed by the use of a dual solvatochromic cross-linking probe and solution-phase NMR spectroscopy. The chain-flipping mechanism was visualized by single-molecule fluorescence techniques, thus demonstrating specificity between the Escherichia coli ACP and its ketoacyl synthase catalytic partner KASII." @default.
• W2140054852 created "2016-06-24" @default.
• W2140054852 creator A5044142335 @default.
• W2140054852 creator A5066889533 @default.
• W2140054852 creator A5071992013 @default.
• W2140054852 date "2014-10-29" @default.
• W2140054852 modified "2023-09-23" @default.
• W2140054852 title "Visualizing the Chain-Flipping Mechanism in Fatty-Acid Biosynthesis" @default.
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• W2140054852 doi "https://doi.org/10.1002/anie.201408576" @default.
• W2140054852 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4425425" @default.
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• W2140054852 hasPublicationYear "2014" @default.
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