FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140056429> ?p ?o ?g. }

• W2140056429 endingPage "291" @default.
• W2140056429 startingPage "279" @default.
• W2140056429 abstract "Corticosterone concentration and the immune cell composition were measured in rats exposed by intraperitoneal (i.p.) injection to different doses (10-500 mg kg(-1)) of acephate (Ace) and 250 micro g kg(-1) of interleukin 1 (IL-1), either alone or in combination. Two different combination protocols were used: IL-1 and Ace were administered simultaneously; and IL-1 was injected 60 min after Ace administration (sequential exposure). Ace, in a dose- and time-dependent manner, inhibited blood and brain acetylcholinesterase (AChE) activities, increased blood corticosterone concentrations, suppressed blood CD4, CD8, B cell and monocyte contents and increased blood neutrophil counts. The Ace-induced changes lasted for up to 24 h after Ace exposure. Interleukin 1 increased blood corticosterone concentrations without affecting blood or brain AChE activities. The IL-1-induced corticosterone concentration returned to the basal level within 3-10 h after IL-1 exposure. The CD4, CD8, B cell and monocyte counts increased significantly at 10 min after IL-1 exposure. The cell counts decreased gradually thereafter and returned to the basal level within 30 min after IL-1 exposure. Simultaneous exposure of rats to Ace and IL-1 partially suppressed the IL-1-induced increase in the immune cell counts and decreased the immune cell numbers below the basal values. Sequential injection of Ace and IL-1 blocked the IL-1-induced increase in the immune cell numbers. Thus, Ace exposure would impair the normal distribution of immune cells and deregulate the IL-1 response in rats. This study therefore suggests that Ace would suppress the immune cell numbers in blood, thus decreasing an organism's immunity. Ace exposure occurring concurrent with injury would augment the acute-phase response, which would augment the toxic effects of IL-1 and other cytokines, and Ace exposure occurring prior to the injury would suppress or abolish the initial stimulatory effects of IL-1, which would decrease an organism's ability to combat infection or injury." @default.
• W2140056429 created "2016-06-24" @default.
• W2140056429 creator A5016493924 @default.
• W2140056429 creator A5059683938 @default.
• W2140056429 date "2002-01-01" @default.
• W2140056429 modified "2023-09-26" @default.
• W2140056429 title "Immunotoxicity of acute acephate exposure in control or IL-1-challenged rats: correlation between the immune cell composition and corticosteroid concentration in blood" @default.
• W2140056429 cites W1848552725 @default.
• W2140056429 cites W1964081088 @default.
• W2140056429 cites W1967839849 @default.
• W2140056429 cites W1971002455 @default.
• W2140056429 cites W1971048984 @default.
• W2140056429 cites W1972356004 @default.
• W2140056429 cites W1980897426 @default.
• W2140056429 cites W1982166273 @default.
• W2140056429 cites W1983245752 @default.
• W2140056429 cites W1995226963 @default.
• W2140056429 cites W1998086688 @default.
• W2140056429 cites W2005561530 @default.
• W2140056429 cites W2007159852 @default.
• W2140056429 cites W2007771148 @default.
• W2140056429 cites W2008056628 @default.
• W2140056429 cites W2011932673 @default.
• W2140056429 cites W2014232238 @default.
• W2140056429 cites W2015556277 @default.
• W2140056429 cites W2018865313 @default.
• W2140056429 cites W2019083095 @default.
• W2140056429 cites W2023328210 @default.
• W2140056429 cites W2023535191 @default.
• W2140056429 cites W2028377533 @default.
• W2140056429 cites W2029331071 @default.
• W2140056429 cites W2030024768 @default.
• W2140056429 cites W2032712201 @default.
• W2140056429 cites W2043797906 @default.
• W2140056429 cites W2044322976 @default.
• W2140056429 cites W2051036733 @default.
• W2140056429 cites W2061430646 @default.
• W2140056429 cites W2068392981 @default.
• W2140056429 cites W2068478117 @default.
• W2140056429 cites W2068996099 @default.
• W2140056429 cites W2073786039 @default.
• W2140056429 cites W2074149246 @default.
• W2140056429 cites W2078404938 @default.
• W2140056429 cites W2083893685 @default.
• W2140056429 cites W2088280880 @default.
• W2140056429 cites W2091317706 @default.
• W2140056429 cites W2093721506 @default.
• W2140056429 cites W2094628847 @default.
• W2140056429 cites W2109232517 @default.
• W2140056429 cites W2118128882 @default.
• W2140056429 cites W2145890122 @default.
• W2140056429 cites W2154746915 @default.
• W2140056429 cites W2160536056 @default.
• W2140056429 cites W2164322090 @default.
• W2140056429 cites W2501389668 @default.
• W2140056429 cites W4238714531 @default.
• W2140056429 cites W4291032649 @default.
• W2140056429 doi "https://doi.org/10.1002/jat.852" @default.
• W2140056429 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12355557" @default.
• W2140056429 hasPublicationYear "2002" @default.
• W2140056429 type Work @default.
• W2140056429 sameAs 2140056429 @default.
• W2140056429 citedByCount "11" @default.
• W2140056429 countsByYear W21400564292012 @default.
• W2140056429 countsByYear W21400564292013 @default.
• W2140056429 countsByYear W21400564292015 @default.
• W2140056429 countsByYear W21400564292017 @default.
• W2140056429 countsByYear W21400564292018 @default.
• W2140056429 countsByYear W21400564292019 @default.
• W2140056429 countsByYear W21400564292021 @default.
• W2140056429 countsByYear W21400564292022 @default.
• W2140056429 crossrefType "journal-article" @default.
• W2140056429 hasAuthorship W2140056429A5016493924 @default.
• W2140056429 hasAuthorship W2140056429A5059683938 @default.
• W2140056429 hasConcept C126322002 @default.
• W2140056429 hasConcept C134018914 @default.
• W2140056429 hasConcept C167672396 @default.
• W2140056429 hasConcept C181199279 @default.
• W2140056429 hasConcept C185592680 @default.
• W2140056429 hasConcept C203014093 @default.
• W2140056429 hasConcept C2778024521 @default.
• W2140056429 hasConcept C2778816929 @default.
• W2140056429 hasConcept C2779979121 @default.
• W2140056429 hasConcept C2780352252 @default.
• W2140056429 hasConcept C2781184567 @default.
• W2140056429 hasConcept C55493867 @default.
• W2140056429 hasConcept C555293320 @default.
• W2140056429 hasConcept C71315377 @default.
• W2140056429 hasConcept C71924100 @default.
• W2140056429 hasConcept C86803240 @default.
• W2140056429 hasConcept C8891405 @default.
• W2140056429 hasConceptScore W2140056429C126322002 @default.
• W2140056429 hasConceptScore W2140056429C134018914 @default.
• W2140056429 hasConceptScore W2140056429C167672396 @default.
• W2140056429 hasConceptScore W2140056429C181199279 @default.
• W2140056429 hasConceptScore W2140056429C185592680 @default.
• W2140056429 hasConceptScore W2140056429C203014093 @default.
• W2140056429 hasConceptScore W2140056429C2778024521 @default.

• next