Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140066278> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2140066278 endingPage "1104" @default.
- W2140066278 startingPage "1102" @default.
- W2140066278 abstract "Homocysteine is formed by demethylation of methionine and is involved in transmethylation mechanisms. Hyperhomocysteinemia is associated with a wide range of clinical manifestations, mostly affecting the central nervous system (e.g., mental retardation, cerebral atrophy, and epileptic seizures) (1)(2). Hyperhomocysteinemia has also been associated with an increased risk for atherosclerotic and thrombotic vascular diseases (3)(4)(5). Although various mechanisms have been proposed, mostly involving endothelial damage related to increased oxidative stress (6), the exact cellular and molecular bases for the adverse effects of homocysteine are still elusive.Alterations in transmethylation reactions that lead to hyperhomocysteinemia have been suggested in the pathophysiology of neurodegenerative disorders such as Alzheimer disease and Parkinson disease (PD) (7)(8). Furthermore, the potential role of homocysteine in neurodegeneration has recently been pointed out by a study showing that the amino acid induces apoptosis in cultures of hippocampal neurons (9).The processes of methyl-group transfer are involved in the metabolism of l-3,4-dihydroxyphenylalanine (l-DOPA), the most effective drug used for the therapy of PD (10). The main metabolism of l-DOPA is its O-methylation to form 3- O -methyldopa (3-OMD). The reaction involves the enzyme catechol- O -methyl-transferase, with S -adenosylmethionine as methyl-group donor. Demethylation of S -adenosylmethionine forms S -adenosylhomocysteine, which is hydrolyzed to homocysteine. Homocysteine is then metabolized via a transsulfuration pathway, forming cystathionine, or a remethylation cycle, which leads back to methionine (11). The catabolism of l-DOPA might therefore interfere, at various steps, with homocysteine metabolism. Indeed, there is experimental evidence that l-DOPA administration increases concentrations of plasma homocysteine (12) and cerebral S -adenosylhomocysteine (12)(13). In PD patients treated with l-DOPA, plasma homocysteine is higher than in controls and untreated PD patients (14)(15)(16)(17). This further supports …" @default.
- W2140066278 created "2016-06-24" @default.
- W2140066278 creator A5007019878 @default.
- W2140066278 creator A5007630827 @default.
- W2140066278 creator A5023542448 @default.
- W2140066278 creator A5033117643 @default.
- W2140066278 creator A5034094180 @default.
- W2140066278 creator A5074464956 @default.
- W2140066278 creator A5089311139 @default.
- W2140066278 date "2001-06-01" @default.
- W2140066278 modified "2023-10-16" @default.
- W2140066278 title "Plasma Homocysteine and l-DOPA Metabolism in Patients with Parkinson Disease" @default.
- W2140066278 cites W1967635119 @default.
- W2140066278 cites W1969280474 @default.
- W2140066278 cites W1984212373 @default.
- W2140066278 cites W1996438584 @default.
- W2140066278 cites W2002732576 @default.
- W2140066278 cites W2009161818 @default.
- W2140066278 cites W2023453837 @default.
- W2140066278 cites W2027991819 @default.
- W2140066278 cites W2030257414 @default.
- W2140066278 cites W2039932104 @default.
- W2140066278 cites W2044681613 @default.
- W2140066278 cites W2053447410 @default.
- W2140066278 cites W2079015341 @default.
- W2140066278 cites W2084766531 @default.
- W2140066278 cites W2088243607 @default.
- W2140066278 cites W2091329460 @default.
- W2140066278 cites W2111586190 @default.
- W2140066278 cites W2126230337 @default.
- W2140066278 cites W2130271075 @default.
- W2140066278 cites W2165360441 @default.
- W2140066278 cites W4230210723 @default.
- W2140066278 doi "https://doi.org/10.1093/clinchem/47.6.1102" @default.
- W2140066278 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11375298" @default.
- W2140066278 hasPublicationYear "2001" @default.
- W2140066278 type Work @default.
- W2140066278 sameAs 2140066278 @default.
- W2140066278 citedByCount "98" @default.
- W2140066278 countsByYear W21400662782012 @default.
- W2140066278 countsByYear W21400662782013 @default.
- W2140066278 countsByYear W21400662782014 @default.
- W2140066278 countsByYear W21400662782015 @default.
- W2140066278 countsByYear W21400662782016 @default.
- W2140066278 countsByYear W21400662782017 @default.
- W2140066278 countsByYear W21400662782018 @default.
- W2140066278 countsByYear W21400662782019 @default.
- W2140066278 countsByYear W21400662782020 @default.
- W2140066278 countsByYear W21400662782021 @default.
- W2140066278 countsByYear W21400662782022 @default.
- W2140066278 countsByYear W21400662782023 @default.
- W2140066278 crossrefType "journal-article" @default.
- W2140066278 hasAuthorship W2140066278A5007019878 @default.
- W2140066278 hasAuthorship W2140066278A5007630827 @default.
- W2140066278 hasAuthorship W2140066278A5023542448 @default.
- W2140066278 hasAuthorship W2140066278A5033117643 @default.
- W2140066278 hasAuthorship W2140066278A5034094180 @default.
- W2140066278 hasAuthorship W2140066278A5074464956 @default.
- W2140066278 hasAuthorship W2140066278A5089311139 @default.
- W2140066278 hasBestOaLocation W21400662781 @default.
- W2140066278 hasConcept C126322002 @default.
- W2140066278 hasConcept C134018914 @default.
- W2140066278 hasConcept C2777090595 @default.
- W2140066278 hasConcept C2779134260 @default.
- W2140066278 hasConcept C2779734285 @default.
- W2140066278 hasConcept C3017560507 @default.
- W2140066278 hasConcept C62231903 @default.
- W2140066278 hasConcept C71924100 @default.
- W2140066278 hasConcept C98274493 @default.
- W2140066278 hasConceptScore W2140066278C126322002 @default.
- W2140066278 hasConceptScore W2140066278C134018914 @default.
- W2140066278 hasConceptScore W2140066278C2777090595 @default.
- W2140066278 hasConceptScore W2140066278C2779134260 @default.
- W2140066278 hasConceptScore W2140066278C2779734285 @default.
- W2140066278 hasConceptScore W2140066278C3017560507 @default.
- W2140066278 hasConceptScore W2140066278C62231903 @default.
- W2140066278 hasConceptScore W2140066278C71924100 @default.
- W2140066278 hasConceptScore W2140066278C98274493 @default.
- W2140066278 hasIssue "6" @default.
- W2140066278 hasLocation W21400662781 @default.
- W2140066278 hasLocation W21400662782 @default.
- W2140066278 hasOpenAccess W2140066278 @default.
- W2140066278 hasPrimaryLocation W21400662781 @default.
- W2140066278 hasRelatedWork W1966504330 @default.
- W2140066278 hasRelatedWork W1979139803 @default.
- W2140066278 hasRelatedWork W2041949500 @default.
- W2140066278 hasRelatedWork W2057983179 @default.
- W2140066278 hasRelatedWork W2060846002 @default.
- W2140066278 hasRelatedWork W2342015447 @default.
- W2140066278 hasRelatedWork W2361567948 @default.
- W2140066278 hasRelatedWork W2372498645 @default.
- W2140066278 hasRelatedWork W2595654912 @default.
- W2140066278 hasRelatedWork W2748952813 @default.
- W2140066278 hasVolume "47" @default.
- W2140066278 isParatext "false" @default.
- W2140066278 isRetracted "false" @default.
- W2140066278 magId "2140066278" @default.
- W2140066278 workType "article" @default.