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• W2140088374 endingPage "24" @default.
• W2140088374 startingPage "16" @default.
• W2140088374 abstract "The production of cellular RNAs is tightly regulated to ensure gene expression is limited to appropriate times and locations. Elimination of RNA can be rapid and programmed to quickly terminate gene expression, or can be used to purge old, damaged or inappropriately formed RNAs. It is elimination of RNAs through the action of a polyadenylation complex (TRAMP), first described in the yeast Saccharomyces cerevisiae, which is the focus of this review. The discovery of TRAMP and presence of orthologs in most eukaryotes, along with an increasing number of potential TRAMP substrates in the form of new small non-coding RNAs, many of which emanate from areas of genomes once thought transcriptionally silent; promise to make this area of research of great interest for the foreseeable future." @default.
• W2140088374 created "2016-06-24" @default.
• W2140088374 creator A5064074234 @default.
• W2140088374 creator A5070586569 @default.
• W2140088374 date "2009-02-01" @default.
• W2140088374 modified "2023-09-23" @default.
• W2140088374 title "Nuclear RNA surveillance: no sign of substrates tailing off" @default.
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• W2140088374 doi "https://doi.org/10.1080/10409230802640218" @default.
• W2140088374 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19280429" @default.
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