FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140095710> ?p ?o ?g. }

• W2140095710 endingPage "988" @default.
• W2140095710 startingPage "978" @default.
• W2140095710 abstract "Breast cancer at a young age is associated with poor prognosis. The Prospective Study of Outcomes in Sporadic and Hereditary Breast Cancer (POSH) was designed to investigate factors affecting prognosis in this patient group. Between 2000 and 2008, 2956 patients aged 40 years or younger were recruited to a UK multicenter prospective observational cohort study (POSH). Details of tumor pathology, disease stage, treatment received, and outcome were recorded. Overall survival (OS) and distant disease-free interval (DDFI) were assessed using Kaplan-Meier curves. All statistical tests were two-sided. Median age of patients was 36 years. Median tumor diameter was 22mm, and 50% of patients had positive lymph nodes; 59% of tumors were grade 3, 33.7% were estrogen receptor (ER) negative, and 24% were human epidermal growth factor receptor 2 (HER2) positive. Five-year OS was higher for patients with ER-positive than ER-negative tumors (85.0%, 95% confidence interval [CI] = 83.2% to 86.7% vs 75.7%, 95% CI = 72.8% to 78.4%; P < .001), but by eight years, survival was almost equal. The eight-year OS of patients with ER-positive tumors was similar to that of patients with ER-negative tumors in both HER2-positive and HER2-negative subgroups. The flexible parametric survival model for OS shows that the risk of death increases steadily over time for patients with ER-positive tumors in contrast to patients with ER-negative tumors, where risk of death peaked at two years. These results confirm the increased frequency of ER-negative tumors and early relapse in young patients and also demonstrate the equally poor longer-term outlook of young patients who have ER-positive tumors with HER2-negative or -positive disease." @default.
• W2140095710 created "2016-06-24" @default.
• W2140095710 creator A5006665510 @default.
• W2140095710 creator A5028947668 @default.
• W2140095710 creator A5032413818 @default.
• W2140095710 creator A5042962646 @default.
• W2140095710 creator A5049572164 @default.
• W2140095710 creator A5055196026 @default.
• W2140095710 creator A5058840690 @default.
• W2140095710 creator A5062274315 @default.
• W2140095710 creator A5063813179 @default.
• W2140095710 creator A5066580354 @default.
• W2140095710 creator A5067824020 @default.
• W2140095710 creator A5078838870 @default.
• W2140095710 creator A5086199896 @default.
• W2140095710 date "2013-05-30" @default.
• W2140095710 modified "2023-09-30" @default.
• W2140095710 title "Prospective Observational Study of Breast Cancer Treatment Outcomes for UK Women Aged 18–40 Years at Diagnosis: The POSH Study" @default.
• W2140095710 cites W1496735011 @default.
• W2140095710 cites W1543389126 @default.
• W2140095710 cites W1567156145 @default.
• W2140095710 cites W1701849548 @default.
• W2140095710 cites W1925792503 @default.
• W2140095710 cites W1961978963 @default.
• W2140095710 cites W1963505593 @default.
• W2140095710 cites W1965156081 @default.
• W2140095710 cites W1978936622 @default.
• W2140095710 cites W1983154689 @default.
• W2140095710 cites W1984078429 @default.
• W2140095710 cites W1984650452 @default.
• W2140095710 cites W1985236363 @default.
• W2140095710 cites W1994159961 @default.
• W2140095710 cites W1995224853 @default.
• W2140095710 cites W1999479708 @default.
• W2140095710 cites W2000611386 @default.
• W2140095710 cites W2013134830 @default.
• W2140095710 cites W2019134258 @default.
• W2140095710 cites W2038057961 @default.
• W2140095710 cites W2040757096 @default.
• W2140095710 cites W2054205744 @default.
• W2140095710 cites W2055605845 @default.
• W2140095710 cites W2069105213 @default.
• W2140095710 cites W2074162144 @default.
• W2140095710 cites W2091236282 @default.
• W2140095710 cites W2102392885 @default.
• W2140095710 cites W2110406920 @default.
• W2140095710 cites W2143763498 @default.
• W2140095710 cites W2155609785 @default.
• W2140095710 cites W2161849165 @default.
• W2140095710 cites W2161977537 @default.
• W2140095710 cites W2166631738 @default.
• W2140095710 cites W2275737843 @default.
• W2140095710 cites W34384692 @default.
• W2140095710 cites W4239743086 @default.
• W2140095710 doi "https://doi.org/10.1093/jnci/djt134" @default.
• W2140095710 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23723422" @default.
• W2140095710 hasPublicationYear "2013" @default.
• W2140095710 type Work @default.
• W2140095710 sameAs 2140095710 @default.
• W2140095710 citedByCount "147" @default.
• W2140095710 countsByYear W21400957102013 @default.
• W2140095710 countsByYear W21400957102014 @default.
• W2140095710 countsByYear W21400957102015 @default.
• W2140095710 countsByYear W21400957102016 @default.
• W2140095710 countsByYear W21400957102017 @default.
• W2140095710 countsByYear W21400957102018 @default.
• W2140095710 countsByYear W21400957102019 @default.
• W2140095710 countsByYear W21400957102020 @default.
• W2140095710 countsByYear W21400957102021 @default.
• W2140095710 countsByYear W21400957102022 @default.
• W2140095710 countsByYear W21400957102023 @default.
• W2140095710 crossrefType "journal-article" @default.
• W2140095710 hasAuthorship W2140095710A5006665510 @default.
• W2140095710 hasAuthorship W2140095710A5028947668 @default.
• W2140095710 hasAuthorship W2140095710A5032413818 @default.
• W2140095710 hasAuthorship W2140095710A5042962646 @default.
• W2140095710 hasAuthorship W2140095710A5049572164 @default.
• W2140095710 hasAuthorship W2140095710A5055196026 @default.
• W2140095710 hasAuthorship W2140095710A5058840690 @default.
• W2140095710 hasAuthorship W2140095710A5062274315 @default.
• W2140095710 hasAuthorship W2140095710A5063813179 @default.
• W2140095710 hasAuthorship W2140095710A5066580354 @default.
• W2140095710 hasAuthorship W2140095710A5067824020 @default.
• W2140095710 hasAuthorship W2140095710A5078838870 @default.
• W2140095710 hasAuthorship W2140095710A5086199896 @default.
• W2140095710 hasBestOaLocation W21400957101 @default.
• W2140095710 hasConcept C121608353 @default.
• W2140095710 hasConcept C126322002 @default.
• W2140095710 hasConcept C143998085 @default.
• W2140095710 hasConcept C146357865 @default.
• W2140095710 hasConcept C151730666 @default.
• W2140095710 hasConcept C188816634 @default.
• W2140095710 hasConcept C29456083 @default.
• W2140095710 hasConcept C44249647 @default.
• W2140095710 hasConcept C530470458 @default.
• W2140095710 hasConcept C71924100 @default.
• W2140095710 hasConcept C84606932 @default.
• W2140095710 hasConcept C86803240 @default.

• next