Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140130362> ?p ?o ?g. }
- W2140130362 endingPage "97" @default.
- W2140130362 startingPage "2689" @default.
- W2140130362 abstract "Although the protein-induced vitamin K absence or antagonist-II (PIVKA-II) is used as a prognostic marker in hepatocellular carcinoma (HCC), a newly-improved assay, NX-PVKA (PIVKA-II measured using P-11 and P-16 antibodies) and NX-PVKA-R (ratio of PIVKA-II and NX-PVKA), are more accurate markers of PIVKA-II. We conducted a prospectively preliminary analysis of the relationship between NX-PVKA-R and clinicopathological parameters and prognosis in 22 patients with HCC who underwent hepatectomy and measured changes of this marker's levels after treatment. Median value of PIVKA-II (80 mAU/ml), NX-PVKA (60 mAU/ml), NX-PVKA-R (1.5) and NX-PVKA-D (difference of markers, 15 mAU/ml) were determined. Tumor relapse was observed in six patients, and the one year relapse-free survival rate was 88%. Correlation between PIVKA-II or alpha-fetoprotein levels and NX-PVKA, NX-PVKA-R or -D levels was significant (p<0.001). NX-PVKA-R was significantly correlated with tumor size (p<0.05). In patients who underwent pre-treatment before hepatectomy, PIVKA-II, NX-PVKA and NX-PVKA-R tended to be higher than in patients without pre-treatment, but this difference was not significant (p>0.10). For macroscopic findings, NX-PVKA-R for the confluent-nodular type was significantly higher than that for the simple-nodular type (p<0.05). The tumor-free survival rate in the group with a high NX-PVKA-R was significantly lower than that in the group with a low NX-PVKA-R group (p<0.05). In patients with tumor recurrence, postoperative NX-PVKA-R increased again. We conclude that a high value of NX-PVKA-R after hepatectomy for HCC reflects malignant potential and predicts early recurrence in patients with HCC." @default.
- W2140130362 created "2016-06-24" @default.
- W2140130362 creator A5004092735 @default.
- W2140130362 creator A5019163110 @default.
- W2140130362 creator A5023396882 @default.
- W2140130362 creator A5025201163 @default.
- W2140130362 creator A5047668634 @default.
- W2140130362 creator A5053773418 @default.
- W2140130362 creator A5061565206 @default.
- W2140130362 creator A5063764510 @default.
- W2140130362 creator A5064919937 @default.
- W2140130362 date "2013-06-01" @default.
- W2140130362 modified "2023-09-23" @default.
- W2140130362 title "NX-PVKA levels before and after hepatectomy of hepatocellular carcinoma as predictors of patient survival: a preliminary evaluation of an improved assay for PIVKA-II." @default.
- W2140130362 cites W1518093405 @default.
- W2140130362 cites W1848819223 @default.
- W2140130362 cites W19356402 @default.
- W2140130362 cites W1946981324 @default.
- W2140130362 cites W1968509951 @default.
- W2140130362 cites W1975287687 @default.
- W2140130362 cites W1978935379 @default.
- W2140130362 cites W1978970861 @default.
- W2140130362 cites W1985563983 @default.
- W2140130362 cites W1991374040 @default.
- W2140130362 cites W1995180061 @default.
- W2140130362 cites W1999137575 @default.
- W2140130362 cites W2004261972 @default.
- W2140130362 cites W2005782838 @default.
- W2140130362 cites W2021080308 @default.
- W2140130362 cites W2029055387 @default.
- W2140130362 cites W2033198115 @default.
- W2140130362 cites W2037871324 @default.
- W2140130362 cites W2053794460 @default.
- W2140130362 cites W2055702442 @default.
- W2140130362 cites W2059530774 @default.
- W2140130362 cites W2059539389 @default.
- W2140130362 cites W2060048971 @default.
- W2140130362 cites W2085931229 @default.
- W2140130362 cites W2086452516 @default.
- W2140130362 cites W2087222895 @default.
- W2140130362 cites W2095231896 @default.
- W2140130362 cites W2106497916 @default.
- W2140130362 cites W2129111322 @default.
- W2140130362 cites W2159823218 @default.
- W2140130362 cites W2170081244 @default.
- W2140130362 cites W2280392615 @default.
- W2140130362 cites W2336370290 @default.
- W2140130362 cites W2399512893 @default.
- W2140130362 cites W2406160172 @default.
- W2140130362 cites W2430210736 @default.
- W2140130362 cites W2438463082 @default.
- W2140130362 cites W2468532339 @default.
- W2140130362 cites W3144590041 @default.
- W2140130362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23749928" @default.
- W2140130362 hasPublicationYear "2013" @default.
- W2140130362 type Work @default.
- W2140130362 sameAs 2140130362 @default.
- W2140130362 citedByCount "4" @default.
- W2140130362 countsByYear W21401303622015 @default.
- W2140130362 countsByYear W21401303622016 @default.
- W2140130362 countsByYear W21401303622022 @default.
- W2140130362 crossrefType "journal-article" @default.
- W2140130362 hasAuthorship W2140130362A5004092735 @default.
- W2140130362 hasAuthorship W2140130362A5019163110 @default.
- W2140130362 hasAuthorship W2140130362A5023396882 @default.
- W2140130362 hasAuthorship W2140130362A5025201163 @default.
- W2140130362 hasAuthorship W2140130362A5047668634 @default.
- W2140130362 hasAuthorship W2140130362A5053773418 @default.
- W2140130362 hasAuthorship W2140130362A5061565206 @default.
- W2140130362 hasAuthorship W2140130362A5063764510 @default.
- W2140130362 hasAuthorship W2140130362A5064919937 @default.
- W2140130362 hasConcept C121608353 @default.
- W2140130362 hasConcept C126322002 @default.
- W2140130362 hasConcept C141071460 @default.
- W2140130362 hasConcept C159110652 @default.
- W2140130362 hasConcept C2776909242 @default.
- W2140130362 hasConcept C2778019345 @default.
- W2140130362 hasConcept C2781447364 @default.
- W2140130362 hasConcept C71924100 @default.
- W2140130362 hasConcept C90924648 @default.
- W2140130362 hasConceptScore W2140130362C121608353 @default.
- W2140130362 hasConceptScore W2140130362C126322002 @default.
- W2140130362 hasConceptScore W2140130362C141071460 @default.
- W2140130362 hasConceptScore W2140130362C159110652 @default.
- W2140130362 hasConceptScore W2140130362C2776909242 @default.
- W2140130362 hasConceptScore W2140130362C2778019345 @default.
- W2140130362 hasConceptScore W2140130362C2781447364 @default.
- W2140130362 hasConceptScore W2140130362C71924100 @default.
- W2140130362 hasConceptScore W2140130362C90924648 @default.
- W2140130362 hasIssue "6" @default.
- W2140130362 hasLocation W21401303621 @default.
- W2140130362 hasOpenAccess W2140130362 @default.
- W2140130362 hasPrimaryLocation W21401303621 @default.
- W2140130362 hasRelatedWork W1863948449 @default.
- W2140130362 hasRelatedWork W1902403199 @default.
- W2140130362 hasRelatedWork W2005065806 @default.
- W2140130362 hasRelatedWork W2013473002 @default.
- W2140130362 hasRelatedWork W2016940072 @default.