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• W2140132924 abstract "ABSTRACT Clearing blood-stage malaria parasites without inducing major host pathology requires a finely tuned balance between pro- and anti-inflammatory responses. The interplay between regulatory T (Treg) cells and dendritic cells (DCs) is one of the key determinants of this balance. Although experimental models have revealed various patterns of Treg cell expansion, DC maturation, and cytokine production according to the infecting malaria parasite species, no studies have compared all of these parameters in human infections with Plasmodium falciparum and P. vivax in the same setting of endemicity. Here we show that during uncomplicated acute malaria, both species induced a significant expansion of CD4 + CD25 + Foxp3 + Treg cells expressing the key immunomodulatory molecule CTLA-4 and a significant increase in the proportion of DCs that were plasmacytoid (CD123 + ), with a decrease in the myeloid/plasmacytoid DC ratio. These changes were proportional to parasite loads but correlated neither with the intensity of clinical symptoms nor with circulating cytokine levels. One-third of P. vivax -infected patients, but no P. falciparum -infected subjects, showed impaired maturation of circulating DCs, with low surface expression of CD86. Although vivax malaria patients overall had a less inflammatory cytokine response, with a higher interleukin-10 (IL-10)/tumor necrosis factor alpha (TNF-α) ratio, this finding did not translate to milder clinical manifestations than those of falciparum malaria patients. We discuss the potential implications of these findings for species-specific pathogenesis and long-lasting protective immunity to malaria." @default.
• W2140132924 created "2016-06-24" @default.
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• W2140132924 date "2010-11-01" @default.
• W2140132924 modified "2023-10-16" @default.
• W2140132924 title "CD4 ⁺ CD25 ⁺ Foxp3 ⁺ Regulatory T Cells, Dendritic Cells, and Circulating Cytokines in Uncomplicated Malaria: Do Different Parasite Species Elicit Similar Host Responses?" @default.
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• W2140132924 doi "https://doi.org/10.1128/iai.00578-10" @default.
• W2140132924 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2976362" @default.
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• W2140132924 hasPublicationYear "2010" @default.
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