Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140137230> ?p ?o ?g. }
- W2140137230 endingPage "L768" @default.
- W2140137230 startingPage "L760" @default.
- W2140137230 abstract "Increased reactive oxidant intermediates (ROIs) from primed leukocytes have been implicated in the pathogenesis of acid aspiration lung injury. To evaluate the specific role of the phagocyte NADPH oxidase-derived ROIs in acid lung injury, the p47 phox−/− knockout mouse model of chronic granulomatous disease was used. p47 phox−/− mice developed a significantly greater alveolar neutrophilic leukocytosis compared with wild-type mice at all time points after acid injury, with the difference between genotypes being most marked at 48 h. In contrast, the p47 phox−/− mice had a decreased number of macrophages in bronchoalveolar lavage (BAL) compared with wild-type at 48 h after acid or saline aspiration. Albumin concentration in BAL reflecting capillary leak was also greater in p47 phox−/− compared with wild-type mice. BAL concentrations of proinflammatory cytokines and chemokines were greater in p47 phox−/− compared with wild-type mice. These findings suggest that NADPH oxidase, directly or indirectly, plays a role in attenuating the acute neutrophilic response after acid lung injury. We speculate that this downmodulating effect may be mediated by promoting the transition from production of cytokines and chemokines involved in neutrophilic infiltration to a less injurious, chronic inflammatory response." @default.
- W2140137230 created "2016-06-24" @default.
- W2140137230 creator A5000276152 @default.
- W2140137230 creator A5003543931 @default.
- W2140137230 creator A5028399591 @default.
- W2140137230 creator A5035148770 @default.
- W2140137230 creator A5044926801 @default.
- W2140137230 creator A5056552919 @default.
- W2140137230 creator A5059770078 @default.
- W2140137230 creator A5069146590 @default.
- W2140137230 creator A5089211664 @default.
- W2140137230 date "2007-03-01" @default.
- W2140137230 modified "2023-10-15" @default.
- W2140137230 title "Acid aspiration-induced lung inflammation and injury are exacerbated in NADPH oxidase-deficient mice" @default.
- W2140137230 cites W1601166649 @default.
- W2140137230 cites W1910567182 @default.
- W2140137230 cites W1956073601 @default.
- W2140137230 cites W1970935798 @default.
- W2140137230 cites W1972382796 @default.
- W2140137230 cites W1981408889 @default.
- W2140137230 cites W1992214723 @default.
- W2140137230 cites W2007660000 @default.
- W2140137230 cites W2008981570 @default.
- W2140137230 cites W2012558897 @default.
- W2140137230 cites W2019856427 @default.
- W2140137230 cites W2024330176 @default.
- W2140137230 cites W2030935015 @default.
- W2140137230 cites W2038458417 @default.
- W2140137230 cites W2045723131 @default.
- W2140137230 cites W2057098678 @default.
- W2140137230 cites W2057912075 @default.
- W2140137230 cites W2064820057 @default.
- W2140137230 cites W2066453953 @default.
- W2140137230 cites W2069899473 @default.
- W2140137230 cites W2069960650 @default.
- W2140137230 cites W2082566019 @default.
- W2140137230 cites W2084814184 @default.
- W2140137230 cites W2087169058 @default.
- W2140137230 cites W2094290821 @default.
- W2140137230 cites W2104796318 @default.
- W2140137230 cites W2108235369 @default.
- W2140137230 cites W2108790496 @default.
- W2140137230 cites W2138396364 @default.
- W2140137230 cites W2143146617 @default.
- W2140137230 cites W2148916824 @default.
- W2140137230 cites W2163240674 @default.
- W2140137230 cites W2163596679 @default.
- W2140137230 cites W2184363220 @default.
- W2140137230 cites W2290402170 @default.
- W2140137230 cites W2334530874 @default.
- W2140137230 cites W2342791518 @default.
- W2140137230 cites W4237943779 @default.
- W2140137230 doi "https://doi.org/10.1152/ajplung.00281.2006" @default.
- W2140137230 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17114280" @default.
- W2140137230 hasPublicationYear "2007" @default.
- W2140137230 type Work @default.
- W2140137230 sameAs 2140137230 @default.
- W2140137230 citedByCount "49" @default.
- W2140137230 countsByYear W21401372302012 @default.
- W2140137230 countsByYear W21401372302013 @default.
- W2140137230 countsByYear W21401372302014 @default.
- W2140137230 countsByYear W21401372302015 @default.
- W2140137230 countsByYear W21401372302016 @default.
- W2140137230 countsByYear W21401372302017 @default.
- W2140137230 countsByYear W21401372302018 @default.
- W2140137230 countsByYear W21401372302019 @default.
- W2140137230 countsByYear W21401372302020 @default.
- W2140137230 countsByYear W21401372302021 @default.
- W2140137230 countsByYear W21401372302022 @default.
- W2140137230 crossrefType "journal-article" @default.
- W2140137230 hasAuthorship W2140137230A5000276152 @default.
- W2140137230 hasAuthorship W2140137230A5003543931 @default.
- W2140137230 hasAuthorship W2140137230A5028399591 @default.
- W2140137230 hasAuthorship W2140137230A5035148770 @default.
- W2140137230 hasAuthorship W2140137230A5044926801 @default.
- W2140137230 hasAuthorship W2140137230A5056552919 @default.
- W2140137230 hasAuthorship W2140137230A5059770078 @default.
- W2140137230 hasAuthorship W2140137230A5069146590 @default.
- W2140137230 hasAuthorship W2140137230A5089211664 @default.
- W2140137230 hasConcept C121332964 @default.
- W2140137230 hasConcept C126322002 @default.
- W2140137230 hasConcept C13373296 @default.
- W2140137230 hasConcept C153400128 @default.
- W2140137230 hasConcept C160448771 @default.
- W2140137230 hasConcept C164027704 @default.
- W2140137230 hasConcept C185592680 @default.
- W2140137230 hasConcept C203014093 @default.
- W2140137230 hasConcept C2776914184 @default.
- W2140137230 hasConcept C2777700362 @default.
- W2140137230 hasConcept C2777714996 @default.
- W2140137230 hasConcept C2777961210 @default.
- W2140137230 hasConcept C2779719074 @default.
- W2140137230 hasConcept C48349386 @default.
- W2140137230 hasConcept C55493867 @default.
- W2140137230 hasConcept C71924100 @default.
- W2140137230 hasConcept C97355855 @default.
- W2140137230 hasConceptScore W2140137230C121332964 @default.
- W2140137230 hasConceptScore W2140137230C126322002 @default.