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- W2140138697 abstract "Human leucocytes were cultured for 3 days at 37°C, and during this time treated with rubidomycin (also known as daunomycin) for periods up to 48 hr. The effects of this treatment were studied by examining mitotic indices, uptake of 3H-thymidine, and patterns of DNA content (measured by microdensitometry on Feulgen-stained cells). A low concentration of rubidomycin (0.1 μg/ml) caused accumulation of cells in the G2 period, which in turn resulted in a decrease in the mitotic index. A secondary effect was a slight drop in 3H-thymidine uptake after 12 hr. Higher doses (up to 10 μg rubidomycin per ml) caused an inhibition of DNA synthesis, with accumulation of unlabelled cells between G2 and G2. The probable mode of action of rubidomycin, as presented by earlier authors, is the intrusion of the drug molecule between DNA strands, forming a complex with DNA, and hindering its normal folding. This is discussed with respect to the present findings." @default.
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- W2140138697 date "1969-10-01" @default.
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- W2140138697 title "A DELAY IN THE G2PERIOD OF CULTURED HUMAN LEUCOCYTES AFTER TREATMENT WITH RUBIDOMYCIN (DAUNOMYCIN)" @default.
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- W2140138697 doi "https://doi.org/10.1111/j.1365-2184.1969.tb00241.x" @default.
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