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- W2140146273 abstract "Human skin is exposed to solar ultraviolet radiation comprising UVB (280–315 nm) and UVA (315–400 nm) on a daily basis. Within the last two decades, the molecular and cellular response to UVA/UVB and the possible effects on human health have been investigated extensively. It is generally accepted that the mutagenic and carcinogenic properties of UVB is due to the direct interaction with DNA. On the other hand, by interaction with non-DNA chromophores as endogenous photosensitizers, UVA induces formation of reactive oxygen species (ROS), which play a pivotal role as mediators of UVA-induced injuries in human skin. This review gives a short overview about relevant findings concerning the molecular mechanisms underlying UVA/UVB-induced cell death. Furthermore, we will highlight the potential role of cutaneous antioxidants and photolabile nitric oxide derivates (NODs) in skin physiology. UVA-induced decomposition of the NODs, like nitrite, leads not only to non-enzymatic formation of nitric oxide (NO), but also to toxic reactive nitrogen species (RNS), like peroxynitrite. Whereas under antioxidative conditions the generation of protective amounts of NO is favored, under oxidative conditions, less injurious reactive nitrogen species are generated, which may enhance UVA-induced cell death." @default.
- W2140146273 created "2016-06-24" @default.
- W2140146273 creator A5053156391 @default.
- W2140146273 creator A5078443816 @default.
- W2140146273 date "2012-12-21" @default.
- W2140146273 modified "2023-10-04" @default.
- W2140146273 title "The Role of Photolabile Dermal Nitric Oxide Derivates in Ultraviolet Radiation (UVR)-Induced Cell Death" @default.
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- W2140146273 doi "https://doi.org/10.3390/ijms14010191" @default.
- W2140146273 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3565258" @default.
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