Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140147331> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2140147331 endingPage "2156" @default.
- W2140147331 startingPage "2151" @default.
- W2140147331 abstract "Macrophages at sites of inflammation are exposed to proteolytic enzymes derived from neutrophils, platelets, clotting factors, complement, and damaged tissues. To investigate the possible effect of proteases on the plasma membrane-mediated oxidative metabolic response of macrophages in inflammatory sites, cultured human monocyte-derived macrophages were treated in vitro with proteolytic enzymes and were then assayed for their ability to release superoxide anion (O2-) and hydrogen peroxide (H2O2) in response to stimuli. Macrophages pretreated for 1 to 20 min with trypsin, chymotrypsin, pronase, or papain, 0.1 to 200 micrograms/ml, released up to 3.5-times more O2- and H2O2 than did control (untreated) cells. This enhanced production of oxygen metabolites was observed by using either phorbol myristate acetate or opsonized zymosan as the stimulus. Macrophages were also primed for enhanced O2- release (2.3-fold) by pretreatment with a subfraction of granules extracted from human neutrophils. This subfraction contained primarily elastase and cathepsin G. Similar enhancement was observed with 60 ng/ml or purified human neutrophil cathepsin G (2.2-fold) and with 20 micrograms/ml of purified neutrophil elastase (3.3-fold). Priming by these neutrophil proteases could be blocked by specific inhibitors of their proteolytic activity. These results suggest that macrophages involved in an inflammatory response might be rapidly primed by proteases released from degranulating neutrophils. Primed macrophages could mount a more effective oxidative metabolic response to microorganisms or tumor cells, but might also cause greater tissue damage." @default.
- W2140147331 created "2016-06-24" @default.
- W2140147331 creator A5027580772 @default.
- W2140147331 creator A5050036513 @default.
- W2140147331 creator A5060571853 @default.
- W2140147331 creator A5065546914 @default.
- W2140147331 creator A5085064730 @default.
- W2140147331 date "1984-10-01" @default.
- W2140147331 modified "2023-10-05" @default.
- W2140147331 title "Enhanced release of oxygen metabolites by monocyte-derived macrophages exposed to proteolytic enzymes: activity of neutrophil elastase and cathepsin G." @default.
- W2140147331 doi "https://doi.org/10.4049/jimmunol.133.4.2151" @default.
- W2140147331 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6088632" @default.
- W2140147331 hasPublicationYear "1984" @default.
- W2140147331 type Work @default.
- W2140147331 sameAs 2140147331 @default.
- W2140147331 citedByCount "51" @default.
- W2140147331 countsByYear W21401473312012 @default.
- W2140147331 countsByYear W21401473312014 @default.
- W2140147331 countsByYear W21401473312016 @default.
- W2140147331 countsByYear W21401473312018 @default.
- W2140147331 crossrefType "journal-article" @default.
- W2140147331 hasAuthorship W2140147331A5027580772 @default.
- W2140147331 hasAuthorship W2140147331A5050036513 @default.
- W2140147331 hasAuthorship W2140147331A5060571853 @default.
- W2140147331 hasAuthorship W2140147331A5065546914 @default.
- W2140147331 hasAuthorship W2140147331A5085064730 @default.
- W2140147331 hasBestOaLocation W21401473311 @default.
- W2140147331 hasConcept C167844969 @default.
- W2140147331 hasConcept C174106267 @default.
- W2140147331 hasConcept C181199279 @default.
- W2140147331 hasConcept C182220744 @default.
- W2140147331 hasConcept C185592680 @default.
- W2140147331 hasConcept C202751555 @default.
- W2140147331 hasConcept C203014093 @default.
- W2140147331 hasConcept C203565725 @default.
- W2140147331 hasConcept C2776708817 @default.
- W2140147331 hasConcept C2776914184 @default.
- W2140147331 hasConcept C2777132095 @default.
- W2140147331 hasConcept C2778870864 @default.
- W2140147331 hasConcept C2780340462 @default.
- W2140147331 hasConcept C2780795997 @default.
- W2140147331 hasConcept C2781044401 @default.
- W2140147331 hasConcept C2781184567 @default.
- W2140147331 hasConcept C3019223276 @default.
- W2140147331 hasConcept C55493867 @default.
- W2140147331 hasConcept C86803240 @default.
- W2140147331 hasConcept C99971728 @default.
- W2140147331 hasConceptScore W2140147331C167844969 @default.
- W2140147331 hasConceptScore W2140147331C174106267 @default.
- W2140147331 hasConceptScore W2140147331C181199279 @default.
- W2140147331 hasConceptScore W2140147331C182220744 @default.
- W2140147331 hasConceptScore W2140147331C185592680 @default.
- W2140147331 hasConceptScore W2140147331C202751555 @default.
- W2140147331 hasConceptScore W2140147331C203014093 @default.
- W2140147331 hasConceptScore W2140147331C203565725 @default.
- W2140147331 hasConceptScore W2140147331C2776708817 @default.
- W2140147331 hasConceptScore W2140147331C2776914184 @default.
- W2140147331 hasConceptScore W2140147331C2777132095 @default.
- W2140147331 hasConceptScore W2140147331C2778870864 @default.
- W2140147331 hasConceptScore W2140147331C2780340462 @default.
- W2140147331 hasConceptScore W2140147331C2780795997 @default.
- W2140147331 hasConceptScore W2140147331C2781044401 @default.
- W2140147331 hasConceptScore W2140147331C2781184567 @default.
- W2140147331 hasConceptScore W2140147331C3019223276 @default.
- W2140147331 hasConceptScore W2140147331C55493867 @default.
- W2140147331 hasConceptScore W2140147331C86803240 @default.
- W2140147331 hasConceptScore W2140147331C99971728 @default.
- W2140147331 hasIssue "4" @default.
- W2140147331 hasLocation W21401473311 @default.
- W2140147331 hasLocation W21401473312 @default.
- W2140147331 hasOpenAccess W2140147331 @default.
- W2140147331 hasPrimaryLocation W21401473311 @default.
- W2140147331 hasRelatedWork W139787999 @default.
- W2140147331 hasRelatedWork W1482421531 @default.
- W2140147331 hasRelatedWork W194877528 @default.
- W2140147331 hasRelatedWork W2002471738 @default.
- W2140147331 hasRelatedWork W2137522692 @default.
- W2140147331 hasRelatedWork W2140147331 @default.
- W2140147331 hasRelatedWork W2246380774 @default.
- W2140147331 hasRelatedWork W2412794112 @default.
- W2140147331 hasRelatedWork W4213345136 @default.
- W2140147331 hasRelatedWork W4376121834 @default.
- W2140147331 hasVolume "133" @default.
- W2140147331 isParatext "false" @default.
- W2140147331 isRetracted "false" @default.
- W2140147331 magId "2140147331" @default.
- W2140147331 workType "article" @default.