Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140149558> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2140149558 endingPage "67" @default.
- W2140149558 startingPage "63" @default.
- W2140149558 abstract "Abstract The plasma binding of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide (AC) was investigated in-vitro by equilibrium dialysis for 3 h at 37°C against isotonic phosphate buffer (pH 7·35) using [3H]AC. There were significant species differences with the smallest % free fraction (mean ± s.d.) occurring in human plasma (3·4 ± 0·2), followed by dog (8·1 ±0·4), mouse (14·8 ± 0·8), rat (16·3 ± 0·9) and rabbit (20·2 ± 0·7). In plasma from healthy individuals (n = 5), the % free fraction ranged from 2·7 to 3·8. In physiological solutions of human proteins, the greatest binding was observed for α-acid glycoprotein (AAG) (0·75 g L−1) with a mean free fraction of 24·1 ± 2·2%, followed by albumin (40 g L−1) with 31·6 ± 0·7 and 39·8 ± 2·5% for fatty-acid-free and globulin-free, respectively. There was also some binding to globulins (5 g L−1) with a mean % free fraction of 70·3 ± 1·6 and 84·8 ± 2·2 for Conn’s fraction I and IV, respectively. Binding data from the displacement of [3H]AC by increasing concentrations of AC in human AAG (0·75 g L−1) or albumin solution (40 g L−1) indicated that AAG had 10-fold greater binding affinity for AC (Ka, 7·8 × 104 m−1) compared with albumin (Ka, 6·8 × 103 m−1). In human plasma enriched with AAG there was a significant negative linear correlation (r = 0·932; P < 0·001) between % AC free fraction and increasing AAG concentration over the range 0·6–4·5 g L−1. Small but significant (P < 0·05) increases in AC free fraction occurred in the presence of various metabolites (50 and 100 μm) but, of those tested, only N-monomethyl-acridine carboxamide increased the free fraction to the same extent as parent AC." @default.
- W2140149558 created "2016-06-24" @default.
- W2140149558 creator A5056011943 @default.
- W2140149558 creator A5058008284 @default.
- W2140149558 creator A5077331422 @default.
- W2140149558 date "1994-01-01" @default.
- W2140149558 modified "2023-10-14" @default.
- W2140149558 title "Plasma Protein Binding of the Experimental Antitumour Agent Acridine-4-carboxamide in Man, Dog, Rat and Rabbit" @default.
- W2140149558 cites W1970817434 @default.
- W2140149558 cites W1972387119 @default.
- W2140149558 cites W2003226308 @default.
- W2140149558 cites W2004180639 @default.
- W2140149558 cites W2027779636 @default.
- W2140149558 cites W2045941088 @default.
- W2140149558 cites W2055249519 @default.
- W2140149558 cites W2061163224 @default.
- W2140149558 cites W2074672769 @default.
- W2140149558 cites W2084155245 @default.
- W2140149558 cites W2158331353 @default.
- W2140149558 cites W2169456841 @default.
- W2140149558 doi "https://doi.org/10.1111/j.2042-7158.1994.tb03722.x" @default.
- W2140149558 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8201529" @default.
- W2140149558 hasPublicationYear "1994" @default.
- W2140149558 type Work @default.
- W2140149558 sameAs 2140149558 @default.
- W2140149558 citedByCount "19" @default.
- W2140149558 countsByYear W21401495582012 @default.
- W2140149558 countsByYear W21401495582016 @default.
- W2140149558 countsByYear W21401495582021 @default.
- W2140149558 countsByYear W21401495582023 @default.
- W2140149558 crossrefType "journal-article" @default.
- W2140149558 hasAuthorship W2140149558A5056011943 @default.
- W2140149558 hasAuthorship W2140149558A5058008284 @default.
- W2140149558 hasAuthorship W2140149558A5077331422 @default.
- W2140149558 hasConcept C134018914 @default.
- W2140149558 hasConcept C146543888 @default.
- W2140149558 hasConcept C165616093 @default.
- W2140149558 hasConcept C185592680 @default.
- W2140149558 hasConcept C202751555 @default.
- W2140149558 hasConcept C2776125364 @default.
- W2140149558 hasConcept C2778597219 @default.
- W2140149558 hasConcept C2781233306 @default.
- W2140149558 hasConcept C51639874 @default.
- W2140149558 hasConcept C55493867 @default.
- W2140149558 hasConcept C81358767 @default.
- W2140149558 hasConcept C86803240 @default.
- W2140149558 hasConceptScore W2140149558C134018914 @default.
- W2140149558 hasConceptScore W2140149558C146543888 @default.
- W2140149558 hasConceptScore W2140149558C165616093 @default.
- W2140149558 hasConceptScore W2140149558C185592680 @default.
- W2140149558 hasConceptScore W2140149558C202751555 @default.
- W2140149558 hasConceptScore W2140149558C2776125364 @default.
- W2140149558 hasConceptScore W2140149558C2778597219 @default.
- W2140149558 hasConceptScore W2140149558C2781233306 @default.
- W2140149558 hasConceptScore W2140149558C51639874 @default.
- W2140149558 hasConceptScore W2140149558C55493867 @default.
- W2140149558 hasConceptScore W2140149558C81358767 @default.
- W2140149558 hasConceptScore W2140149558C86803240 @default.
- W2140149558 hasIssue "1" @default.
- W2140149558 hasLocation W21401495581 @default.
- W2140149558 hasLocation W21401495582 @default.
- W2140149558 hasOpenAccess W2140149558 @default.
- W2140149558 hasPrimaryLocation W21401495581 @default.
- W2140149558 hasRelatedWork W1572524876 @default.
- W2140149558 hasRelatedWork W2042059223 @default.
- W2140149558 hasRelatedWork W2062993780 @default.
- W2140149558 hasRelatedWork W2073638061 @default.
- W2140149558 hasRelatedWork W2089115627 @default.
- W2140149558 hasRelatedWork W2400690486 @default.
- W2140149558 hasRelatedWork W2417215646 @default.
- W2140149558 hasRelatedWork W2426588295 @default.
- W2140149558 hasRelatedWork W3202259820 @default.
- W2140149558 hasRelatedWork W4317743663 @default.
- W2140149558 hasVolume "46" @default.
- W2140149558 isParatext "false" @default.
- W2140149558 isRetracted "false" @default.
- W2140149558 magId "2140149558" @default.
- W2140149558 workType "article" @default.