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- W2140185626 abstract "Activated B cells and T cells express CD154/CD40 ligand in vitro. The in vivo expression and function of B cell CD154 remain unclear and therefore were examined. Tonsillar B and T cells expressed CD154 at a similar density both in situ and immediately ex vivo, whereas a significantly higher percentage of the former expressed CD154. CD154-expressing B cells were most frequent in the CD38positiveIgD+ pre-germinal center (GC)/GC founder, CD38positive GC and CD38-IgD- memory populations, and were also found in the CD38-IgD+ naive and CD38brightIgD+ plasmablast subsets, but not in the CD38brightIgD- plasma cell subset. B cell expression of CD154 was induced by engaging surface Ig or CD40 by signals that predominantly involved activation of AP-1/NF-AT and NF-kappaB, respectively. The functional importance of CD154-mediated homotypic B cell interactions in vivo was indicated by the finding that mAb to CD154 inhibited differentiation of CD38positiveIgD- GC B cells to CD38-IgD- memory cells. In addition, mAb to CD154 inhibited proliferation induced by engaging sIg or CD40, indicating the role of up-regulation of this molecule in facilitating B cell responsiveness. Of note, CD154 itself not only functioned as a ligand but also as a direct signaling molecule as anti-CD154-conjugated Sepharose beads costimulated B cell responses induced by engaging surface Ig. These results indicate that CD154 is expressed by human B cells in vivo and plays an important role in mediating B cell responses." @default.
- W2140185626 created "2016-06-24" @default.
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- W2140185626 creator A5080700269 @default.
- W2140185626 date "1999-10-15" @default.
- W2140185626 modified "2023-10-10" @default.
- W2140185626 title "Expression, Regulation, and Function of B Cell-Expressed CD154 in Germinal Centers" @default.
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- W2140185626 doi "https://doi.org/10.4049/jimmunol.163.8.4150" @default.
- W2140185626 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10510350" @default.
- W2140185626 hasPublicationYear "1999" @default.
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