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• W2140211022 endingPage "1279" @default.
• W2140211022 startingPage "1270" @default.
• W2140211022 abstract "ABSTRACT The genome of Borrelia burgdorferi , the Lyme disease spirochete, encodes a homolog (the bb0184 gene product) of the carbon storage regulator A protein (CsrA Bb ); recent studies reported that CsrA Bb is involved in the regulation of several infectivity factors of B. burgdorferi . However, the mechanism involved remains unknown. In this report, a csrA Bb mutant was constructed and complemented in an infectious B31A3 strain. Subsequent animal studies showed that the mutant failed to establish an infection in mice, highlighting that CsrA Bb is required for the infectivity of B. burgdorferi . Western blot analyses revealed that the virulence-associated factors OspC, DbpB, and DbpA were attenuated in the csrA Bb mutant. The Rrp2-RpoN-RpoS pathway (σ 54 -σ S sigma factor cascade) is a central regulon that governs the expression of ospC , dbpB , and dbpA . Further analyses found that the level of RpoS was significantly decreased in the mutant, while the level of Rrp2 remained unchanged. A recent study reported that the overexpression of BB0589, a phosphate acetyl-transferase (Pta) that converts acetyl-phosphate to acetyl-coenzyme A (CoA), led to the inhibition of RpoS and OspC expression, suggesting that acetyl-phosphate is an activator of Rrp2. Along with this report, we found that CsrA Bb binds to the leader sequence of the bb0589 transcript and that the intracellular level of acetyl-CoA in the csrA Bb mutant was significantly increased compared to that of the wild type, suggesting that more acetyl-phosphate was being converted to acetyl-CoA in the mutant. Collectively, these results suggest that CsrA Bb may influence the infectivity of B. burgdorferi via regulation of acetate metabolism and subsequent activation of the Rrp2-RpoN-RpoS pathway." @default.
• W2140211022 created "2016-06-24" @default.
• W2140211022 creator A5007739990 @default.
• W2140211022 creator A5020955650 @default.
• W2140211022 date "2011-03-01" @default.
• W2140211022 modified "2023-09-27" @default.
• W2140211022 title "Inactivation of <i>bb0184</i> , Which Encodes Carbon Storage Regulator A, Represses the Infectivity of <i>Borrelia burgdorferi</i>" @default.
• W2140211022 cites W1557420229 @default.
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• W2140211022 cites W1918958692 @default.
• W2140211022 cites W1937263263 @default.
• W2140211022 cites W1945783569 @default.
• W2140211022 cites W1946717434 @default.
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• W2140211022 doi "https://doi.org/10.1128/iai.00871-10" @default.
• W2140211022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3067481" @default.
• W2140211022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21173314" @default.
• W2140211022 hasPublicationYear "2011" @default.
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