Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140214638> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2140214638 endingPage "756" @default.
- W2140214638 startingPage "753" @default.
- W2140214638 abstract "1 The effects of a number of purine analogues were examined on the rat isolated colon muscularis mucosae. Adenosine, adenosine 5′-monophosphate (AMP), adenosine 5′-diphosphate (ADP), adenosine 5′-triphosphate (ATP), 2-methylthioATP (MeSATP), adenosine 5′-(2-fluorodiphosphate) (ADPβF), adenosine 5′-(β,γ-methylene)triphosphonate (AM PPCP) and adenosine 5′-(α,β-methylene)triphosphonate (AMPCPP) each contracted the muscularis mucosae in the concentration range 1–100 μm. 2 MeSATP was the most potent purine agonist, with a threshold concentration for contraction of 0.05 μm and an EC50 of approximately 0.3 μm, and AMPCPP was less potent than ATP. The enantiomer of AMPPCP, l-AMPPCP, was inactive at concentrations up to 100 μm. 3 The adenosine receptor antagonist 8-(p-sulphophenyl)theophylline (8-SPT, 50 μm) produced approximately 50 fold shifts of the dose-response curves to adenosine, AMP and AMPPCP, whereas those to ATP, MeSATP and substance P (SP) were unaffected. Intermediate shifts were observed for the dose-response curves to ADP, AD$1βF and AMPCPP. With a lower concentration of 8-SPT (10 μm) a dose ratio of approximately 11 was observed for the inhibition of the effects of both adenosine and AMPPCP. 4 ATP was rapidly degraded by the tissue to ADP, AMP and adenosine, AD$1βF was more slowly degraded to AMP and adenosine, and no significant degradation of AMPPCP was detected during 20 min incubation. 5 The results are consistent with the existence in the rat colon muscularis mucosae of a mixed population of purine receptors of P2Y and P1 types. The colon thus contains the first documented incidence of a P2Y-receptor mediating contraction. The powerful inhibition by the P1-purinoceptor antagonist 8-SPT of the effects of AMPPCP suggests that its action in this tissue is mediated by P1-purinoceptors, although 8-SPT was more potent here than has previously been demonstrated." @default.
- W2140214638 created "2016-06-24" @default.
- W2140214638 creator A5005476151 @default.
- W2140214638 creator A5049609529 @default.
- W2140214638 date "1990-08-01" @default.
- W2140214638 modified "2023-09-28" @default.
- W2140214638 title "A study of the purinoceptors mediating contraction in the rat colon" @default.
- W2140214638 cites W1967578536 @default.
- W2140214638 cites W1978379765 @default.
- W2140214638 cites W1986695784 @default.
- W2140214638 cites W1990833233 @default.
- W2140214638 cites W1991484815 @default.
- W2140214638 cites W2001701544 @default.
- W2140214638 cites W2012861206 @default.
- W2140214638 cites W2022350424 @default.
- W2140214638 cites W2025955902 @default.
- W2140214638 cites W2034544135 @default.
- W2140214638 cites W2041276471 @default.
- W2140214638 cites W2053240189 @default.
- W2140214638 cites W2078323484 @default.
- W2140214638 cites W2085035961 @default.
- W2140214638 cites W2132396639 @default.
- W2140214638 cites W2415587908 @default.
- W2140214638 cites W2474220236 @default.
- W2140214638 cites W5725891 @default.
- W2140214638 doi "https://doi.org/10.1111/j.1476-5381.1990.tb14087.x" @default.
- W2140214638 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1917587" @default.
- W2140214638 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1698498" @default.
- W2140214638 hasPublicationYear "1990" @default.
- W2140214638 type Work @default.
- W2140214638 sameAs 2140214638 @default.
- W2140214638 citedByCount "54" @default.
- W2140214638 countsByYear W21402146382012 @default.
- W2140214638 countsByYear W21402146382013 @default.
- W2140214638 countsByYear W21402146382016 @default.
- W2140214638 crossrefType "journal-article" @default.
- W2140214638 hasAuthorship W2140214638A5005476151 @default.
- W2140214638 hasAuthorship W2140214638A5049609529 @default.
- W2140214638 hasBestOaLocation W21402146382 @default.
- W2140214638 hasConcept C126322002 @default.
- W2140214638 hasConcept C134018914 @default.
- W2140214638 hasConcept C163415756 @default.
- W2140214638 hasConcept C170493617 @default.
- W2140214638 hasConcept C181199279 @default.
- W2140214638 hasConcept C185592680 @default.
- W2140214638 hasConcept C2776476023 @default.
- W2140214638 hasConcept C2776991684 @default.
- W2140214638 hasConcept C2777960253 @default.
- W2140214638 hasConcept C2778938600 @default.
- W2140214638 hasConcept C2779564974 @default.
- W2140214638 hasConcept C55493867 @default.
- W2140214638 hasConcept C57306754 @default.
- W2140214638 hasConcept C67907053 @default.
- W2140214638 hasConcept C71924100 @default.
- W2140214638 hasConcept C86803240 @default.
- W2140214638 hasConceptScore W2140214638C126322002 @default.
- W2140214638 hasConceptScore W2140214638C134018914 @default.
- W2140214638 hasConceptScore W2140214638C163415756 @default.
- W2140214638 hasConceptScore W2140214638C170493617 @default.
- W2140214638 hasConceptScore W2140214638C181199279 @default.
- W2140214638 hasConceptScore W2140214638C185592680 @default.
- W2140214638 hasConceptScore W2140214638C2776476023 @default.
- W2140214638 hasConceptScore W2140214638C2776991684 @default.
- W2140214638 hasConceptScore W2140214638C2777960253 @default.
- W2140214638 hasConceptScore W2140214638C2778938600 @default.
- W2140214638 hasConceptScore W2140214638C2779564974 @default.
- W2140214638 hasConceptScore W2140214638C55493867 @default.
- W2140214638 hasConceptScore W2140214638C57306754 @default.
- W2140214638 hasConceptScore W2140214638C67907053 @default.
- W2140214638 hasConceptScore W2140214638C71924100 @default.
- W2140214638 hasConceptScore W2140214638C86803240 @default.
- W2140214638 hasIssue "4" @default.
- W2140214638 hasLocation W21402146381 @default.
- W2140214638 hasLocation W21402146382 @default.
- W2140214638 hasLocation W21402146383 @default.
- W2140214638 hasLocation W21402146384 @default.
- W2140214638 hasOpenAccess W2140214638 @default.
- W2140214638 hasPrimaryLocation W21402146381 @default.
- W2140214638 hasRelatedWork W1968298430 @default.
- W2140214638 hasRelatedWork W2026105695 @default.
- W2140214638 hasRelatedWork W2031470785 @default.
- W2140214638 hasRelatedWork W2084120262 @default.
- W2140214638 hasRelatedWork W2092017343 @default.
- W2140214638 hasRelatedWork W2160606813 @default.
- W2140214638 hasRelatedWork W2970349209 @default.
- W2140214638 hasRelatedWork W3112151373 @default.
- W2140214638 hasRelatedWork W3215878476 @default.
- W2140214638 hasRelatedWork W81933992 @default.
- W2140214638 hasVolume "100" @default.
- W2140214638 isParatext "false" @default.
- W2140214638 isRetracted "false" @default.
- W2140214638 magId "2140214638" @default.
- W2140214638 workType "article" @default.