FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140217512> ?p ?o ?g. }

• W2140217512 endingPage "2810" @default.
• W2140217512 startingPage "2804" @default.
• W2140217512 abstract "Abstract Motivation: Protein signaling networks play a key role in cellular function, and their dysregulation is central to many diseases, including cancer. To shed light on signaling network topology in specific contexts, such as cancer, requires interrogation of multiple proteins through time and statistical approaches to make inferences regarding network structure. Results: In this study, we use dynamic Bayesian networks to make inferences regarding network structure and thereby generate testable hypotheses. We incorporate existing biology using informative network priors, weighted objectively by an empirical Bayes approach, and exploit a connection between variable selection and network inference to enable exact calculation of posterior probabilities of interest. The approach is computationally efficient and essentially free of user-set tuning parameters. Results on data where the true, underlying network is known place the approach favorably relative to existing approaches. We apply these methods to reverse-phase protein array time-course data from a breast cancer cell line (MDA-MB-468) to predict signaling links that we independently validate using targeted inhibition. The methods proposed offer a general approach by which to elucidate molecular networks specific to biological context, including, but not limited to, human cancers. Availability: http://mukherjeelab.nki.nl/DBN (code and data). Contact: s.hill@nki.nl; gmills@mdanderson.org; s.mukherjee@nki.nl Supplementary information: Supplementary data are available at Bioinformatics online." @default.
• W2140217512 created "2016-06-24" @default.
• W2140217512 creator A5001135422 @default.
• W2140217512 creator A5002359210 @default.
• W2140217512 creator A5005221518 @default.
• W2140217512 creator A5020581776 @default.
• W2140217512 creator A5028899187 @default.
• W2140217512 creator A5044658654 @default.
• W2140217512 creator A5060688708 @default.
• W2140217512 creator A5070040086 @default.
• W2140217512 creator A5084824340 @default.
• W2140217512 date "2012-08-24" @default.
• W2140217512 modified "2023-10-15" @default.
• W2140217512 title "Bayesian Inference of Signaling Network Topology in a Cancer Cell Line" @default.
• W2140217512 cites W1486016120 @default.
• W2140217512 cites W1625086225 @default.
• W2140217512 cites W1997108778 @default.
• W2140217512 cites W2025803032 @default.
• W2140217512 cites W2073307618 @default.
• W2140217512 cites W2095622082 @default.
• W2140217512 cites W2106927126 @default.
• W2140217512 cites W2110297764 @default.
• W2140217512 cites W2115620023 @default.
• W2140217512 cites W2121851657 @default.
• W2140217512 cites W2123183032 @default.
• W2140217512 cites W2126983941 @default.
• W2140217512 cites W2142739240 @default.
• W2140217512 cites W2142826916 @default.
• W2140217512 cites W2153568634 @default.
• W2140217512 cites W2154293840 @default.
• W2140217512 cites W2166920812 @default.
• W2140217512 cites W2170272380 @default.
• W2140217512 cites W2199776355 @default.
• W2140217512 cites W2330192890 @default.
• W2140217512 cites W2611370172 @default.
• W2140217512 cites W2963269335 @default.
• W2140217512 cites W3098834468 @default.
• W2140217512 cites W3102812845 @default.
• W2140217512 doi "https://doi.org/10.1093/bioinformatics/bts514" @default.
• W2140217512 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3476330" @default.
• W2140217512 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22923301" @default.
• W2140217512 hasPublicationYear "2012" @default.
• W2140217512 type Work @default.
• W2140217512 sameAs 2140217512 @default.
• W2140217512 citedByCount "95" @default.
• W2140217512 countsByYear W21402175122013 @default.
• W2140217512 countsByYear W21402175122014 @default.
• W2140217512 countsByYear W21402175122015 @default.
• W2140217512 countsByYear W21402175122016 @default.
• W2140217512 countsByYear W21402175122017 @default.
• W2140217512 countsByYear W21402175122018 @default.
• W2140217512 countsByYear W21402175122019 @default.
• W2140217512 countsByYear W21402175122020 @default.
• W2140217512 countsByYear W21402175122021 @default.
• W2140217512 countsByYear W21402175122023 @default.
• W2140217512 crossrefType "journal-article" @default.
• W2140217512 hasAuthorship W2140217512A5001135422 @default.
• W2140217512 hasAuthorship W2140217512A5002359210 @default.
• W2140217512 hasAuthorship W2140217512A5005221518 @default.
• W2140217512 hasAuthorship W2140217512A5020581776 @default.
• W2140217512 hasAuthorship W2140217512A5028899187 @default.
• W2140217512 hasAuthorship W2140217512A5044658654 @default.
• W2140217512 hasAuthorship W2140217512A5060688708 @default.
• W2140217512 hasAuthorship W2140217512A5070040086 @default.
• W2140217512 hasAuthorship W2140217512A5084824340 @default.
• W2140217512 hasBestOaLocation W21402175121 @default.
• W2140217512 hasConcept C107673813 @default.
• W2140217512 hasConcept C119857082 @default.
• W2140217512 hasConcept C151730666 @default.
• W2140217512 hasConcept C154945302 @default.
• W2140217512 hasConcept C155846161 @default.
• W2140217512 hasConcept C199845137 @default.
• W2140217512 hasConcept C207201462 @default.
• W2140217512 hasConcept C2776214188 @default.
• W2140217512 hasConcept C2779343474 @default.
• W2140217512 hasConcept C28225019 @default.
• W2140217512 hasConcept C31258907 @default.
• W2140217512 hasConcept C33724603 @default.
• W2140217512 hasConcept C41008148 @default.
• W2140217512 hasConcept C70721500 @default.
• W2140217512 hasConcept C82142266 @default.
• W2140217512 hasConcept C86803240 @default.
• W2140217512 hasConceptScore W2140217512C107673813 @default.
• W2140217512 hasConceptScore W2140217512C119857082 @default.
• W2140217512 hasConceptScore W2140217512C151730666 @default.
• W2140217512 hasConceptScore W2140217512C154945302 @default.
• W2140217512 hasConceptScore W2140217512C155846161 @default.
• W2140217512 hasConceptScore W2140217512C199845137 @default.
• W2140217512 hasConceptScore W2140217512C207201462 @default.
• W2140217512 hasConceptScore W2140217512C2776214188 @default.
• W2140217512 hasConceptScore W2140217512C2779343474 @default.
• W2140217512 hasConceptScore W2140217512C28225019 @default.
• W2140217512 hasConceptScore W2140217512C31258907 @default.
• W2140217512 hasConceptScore W2140217512C33724603 @default.
• W2140217512 hasConceptScore W2140217512C41008148 @default.
• W2140217512 hasConceptScore W2140217512C70721500 @default.
• W2140217512 hasConceptScore W2140217512C82142266 @default.
• W2140217512 hasConceptScore W2140217512C86803240 @default.

• next