FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140228045> ?p ?o ?g. }

• W2140228045 endingPage "2301" @default.
• W2140228045 startingPage "2296" @default.
• W2140228045 abstract "Neuropeptide Y (NPY) is a peptide found in a variety of hypothalamic loci which is frequently colocalized with catecholamines. It is also secreted into hypophyseal portal vessels. The injection of NPY into the third ventricle (3V) lowered plasma GH levels in conscious, freely moving male rats. To determine the physiological significance of the hypothalamic inhibitory action of the peptide, highly specific antiserum directed against NPY was injected into the 3V of conscious rats. 3V injection of the antiserum evoked a significant elevation of plasma GH within 2 h on comparison to values in normal rabbit serum-injected, ovariectomized rats. The difference increased and reached a maximum at 6 h after injection. On the other hand, there was no effect of the antiserum in ovariectomized, estrogen, progesterone-blocked rats. Intraventricular injection of the anti-NPY serum also caused a significant elevation of plasma GH within 2 h in normal male rats and the increases above values in normal rat serum-injected control animals became even more significant at 3 and 4 h. To determine the mechanism by which NPY lowers GH after its intraventricular injection, its effect on the release of somatostatin (SRIF) from median eminence fragments incubated in vitro was examined. NPY stimulated SRIF release with a highly significant effect at a concentration of 10(-9) M. Borderline stimulation was observed at doses as low as 10(-11) M. The curve was bell-shaped with a declining release at 10(-8) M and 10(-7) M. The releasing action of NPY was blocked by either the alpha 1-receptor blocker, prazosin (10(-6) M), or the beta-receptor blocker, propranolol (10(-6) M), but was not affected by the alpha 2-receptor blocker, yohimbine (10(-6) M). We conclude that NPY has a physiologically significant inhibitory action within the hypothalamus to suppress GH release in ovariectomized female and intact male rats by stimulation of SRIF release by alpha 1 and beta-adrenergic receptor-mediated mechanisms." @default.
• W2140228045 created "2016-06-24" @default.
• W2140228045 creator A5025033565 @default.
• W2140228045 creator A5054292717 @default.
• W2140228045 creator A5069185819 @default.
• W2140228045 creator A5087226030 @default.
• W2140228045 date "1990-05-01" @default.
• W2140228045 modified "2023-10-15" @default.
• W2140228045 title "Physiologically Significant Effect of Neuropeptide Y to Suppress Growth Hormone Release by Stimulating Somatostatin Discharge*" @default.
• W2140228045 cites W2011274949 @default.
• W2140228045 cites W2022879623 @default.
• W2140228045 cites W2024942055 @default.
• W2140228045 cites W2029604573 @default.
• W2140228045 cites W2053807193 @default.
• W2140228045 cites W2145094342 @default.
• W2140228045 cites W2147025933 @default.
• W2140228045 cites W2305627972 @default.
• W2140228045 cites W2413724905 @default.
• W2140228045 cites W284944624 @default.
• W2140228045 doi "https://doi.org/10.1210/endo-126-5-2296" @default.
• W2140228045 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1970290" @default.
• W2140228045 hasPublicationYear "1990" @default.
• W2140228045 type Work @default.
• W2140228045 sameAs 2140228045 @default.
• W2140228045 citedByCount "95" @default.
• W2140228045 countsByYear W21402280452012 @default.
• W2140228045 countsByYear W21402280452013 @default.
• W2140228045 countsByYear W21402280452014 @default.
• W2140228045 countsByYear W21402280452015 @default.
• W2140228045 countsByYear W21402280452016 @default.
• W2140228045 countsByYear W21402280452017 @default.
• W2140228045 countsByYear W21402280452018 @default.
• W2140228045 countsByYear W21402280452022 @default.
• W2140228045 countsByYear W21402280452023 @default.
• W2140228045 crossrefType "journal-article" @default.
• W2140228045 hasAuthorship W2140228045A5025033565 @default.
• W2140228045 hasAuthorship W2140228045A5054292717 @default.
• W2140228045 hasAuthorship W2140228045A5069185819 @default.
• W2140228045 hasAuthorship W2140228045A5087226030 @default.
• W2140228045 hasConcept C118303440 @default.
• W2140228045 hasConcept C126322002 @default.
• W2140228045 hasConcept C134018914 @default.
• W2140228045 hasConcept C159654299 @default.
• W2140228045 hasConcept C170493617 @default.
• W2140228045 hasConcept C185592680 @default.
• W2140228045 hasConcept C203014093 @default.
• W2140228045 hasConcept C24998067 @default.
• W2140228045 hasConcept C2776297358 @default.
• W2140228045 hasConcept C2777003273 @default.
• W2140228045 hasConcept C2777164284 @default.
• W2140228045 hasConcept C2779067335 @default.
• W2140228045 hasConcept C56191518 @default.
• W2140228045 hasConcept C71315377 @default.
• W2140228045 hasConcept C71924100 @default.
• W2140228045 hasConcept C8264082 @default.
• W2140228045 hasConcept C86803240 @default.
• W2140228045 hasConcept C91523082 @default.
• W2140228045 hasConcept C93984277 @default.
• W2140228045 hasConceptScore W2140228045C118303440 @default.
• W2140228045 hasConceptScore W2140228045C126322002 @default.
• W2140228045 hasConceptScore W2140228045C134018914 @default.
• W2140228045 hasConceptScore W2140228045C159654299 @default.
• W2140228045 hasConceptScore W2140228045C170493617 @default.
• W2140228045 hasConceptScore W2140228045C185592680 @default.
• W2140228045 hasConceptScore W2140228045C203014093 @default.
• W2140228045 hasConceptScore W2140228045C24998067 @default.
• W2140228045 hasConceptScore W2140228045C2776297358 @default.
• W2140228045 hasConceptScore W2140228045C2777003273 @default.
• W2140228045 hasConceptScore W2140228045C2777164284 @default.
• W2140228045 hasConceptScore W2140228045C2779067335 @default.
• W2140228045 hasConceptScore W2140228045C56191518 @default.
• W2140228045 hasConceptScore W2140228045C71315377 @default.
• W2140228045 hasConceptScore W2140228045C71924100 @default.
• W2140228045 hasConceptScore W2140228045C8264082 @default.
• W2140228045 hasConceptScore W2140228045C86803240 @default.
• W2140228045 hasConceptScore W2140228045C91523082 @default.
• W2140228045 hasConceptScore W2140228045C93984277 @default.
• W2140228045 hasIssue "5" @default.
• W2140228045 hasLocation W21402280451 @default.
• W2140228045 hasLocation W21402280452 @default.
• W2140228045 hasOpenAccess W2140228045 @default.
• W2140228045 hasPrimaryLocation W21402280451 @default.
• W2140228045 hasRelatedWork W1555782353 @default.
• W2140228045 hasRelatedWork W1963486488 @default.
• W2140228045 hasRelatedWork W2016127925 @default.
• W2140228045 hasRelatedWork W2019437168 @default.
• W2140228045 hasRelatedWork W2028055137 @default.
• W2140228045 hasRelatedWork W2038614480 @default.
• W2140228045 hasRelatedWork W2050815646 @default.
• W2140228045 hasRelatedWork W2317573249 @default.
• W2140228045 hasRelatedWork W2394888118 @default.
• W2140228045 hasRelatedWork W1967850836 @default.
• W2140228045 hasVolume "126" @default.
• W2140228045 isParatext "false" @default.
• W2140228045 isRetracted "false" @default.
• W2140228045 magId "2140228045" @default.
• W2140228045 workType "article" @default.