Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140228423> ?p ?o ?g. }
- W2140228423 endingPage "79" @default.
- W2140228423 startingPage "75" @default.
- W2140228423 abstract "Anchoring villi are peripheral trophoblastic specializations that attach the placenta to the uterine wall. In addition, they supply the migratory trophoblast population that colonizes the maternal interstitium and arteries during the first 18 weeks of pregnancy. Establishment of anchoring villi and subsequent invasion of maternal uterine stroma and blood vessels play a critical role in pregnancy success; incomplete vascular invasion is associated with common pathological conditions of pregnancy, including spontaneous abortion, pre-eclampsia and growth retardation. Anchoring villi are already present as early as 18 days after ovulation, but new villi develop rapidly as the placenta grows. First trimester mesenchymal floating villi, when confronted with a permissive extracellular matrix (ECM) in explant culture, undergo de novo development of anchoring sites. The cellular and molecular characteristics of these specializations closely resemble those that are seen in vivo. It is postulated that development of new sites is important in the stabilization of placental attachment during growth and development in the first trimester. This may be compromised by function-blocking antibodies which inhibit cell--ECM interactions. This is supported by experiments in vitro as well as by the presence of auto-antibodies to adhesion molecules in women suffering from recurrent spontaneous miscarriage." @default.
- W2140228423 created "2016-06-24" @default.
- W2140228423 creator A5024312297 @default.
- W2140228423 creator A5025546575 @default.
- W2140228423 creator A5038743545 @default.
- W2140228423 creator A5070496356 @default.
- W2140228423 creator A5083821626 @default.
- W2140228423 date "1998-01-01" @default.
- W2140228423 modified "2023-09-30" @default.
- W2140228423 title "Anchorage in the developing placenta: An overlooked determinant of pregnancy outcome?" @default.
- W2140228423 cites W14983815 @default.
- W2140228423 cites W1841503407 @default.
- W2140228423 cites W1936117952 @default.
- W2140228423 cites W1992899196 @default.
- W2140228423 cites W1994916391 @default.
- W2140228423 cites W1999090873 @default.
- W2140228423 cites W2040415481 @default.
- W2140228423 cites W2043045196 @default.
- W2140228423 cites W2059629501 @default.
- W2140228423 cites W2071338376 @default.
- W2140228423 cites W2072177711 @default.
- W2140228423 cites W2073086898 @default.
- W2140228423 cites W2091051860 @default.
- W2140228423 cites W2106127625 @default.
- W2140228423 cites W2110292482 @default.
- W2140228423 cites W2145782275 @default.
- W2140228423 cites W2145809469 @default.
- W2140228423 cites W2153205829 @default.
- W2140228423 cites W2160197166 @default.
- W2140228423 cites W2416399879 @default.
- W2140228423 cites W4211244004 @default.
- W2140228423 cites W4256214420 @default.
- W2140228423 cites W65265034 @default.
- W2140228423 cites W965424580 @default.
- W2140228423 doi "https://doi.org/10.1080/1464727982000198161" @default.
- W2140228423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11844314" @default.
- W2140228423 hasPublicationYear "1998" @default.
- W2140228423 type Work @default.
- W2140228423 sameAs 2140228423 @default.
- W2140228423 citedByCount "24" @default.
- W2140228423 countsByYear W21402284232013 @default.
- W2140228423 countsByYear W21402284232016 @default.
- W2140228423 countsByYear W21402284232017 @default.
- W2140228423 countsByYear W21402284232018 @default.
- W2140228423 countsByYear W21402284232019 @default.
- W2140228423 countsByYear W21402284232020 @default.
- W2140228423 countsByYear W21402284232022 @default.
- W2140228423 countsByYear W21402284232023 @default.
- W2140228423 crossrefType "journal-article" @default.
- W2140228423 hasAuthorship W2140228423A5024312297 @default.
- W2140228423 hasAuthorship W2140228423A5025546575 @default.
- W2140228423 hasAuthorship W2140228423A5038743545 @default.
- W2140228423 hasAuthorship W2140228423A5070496356 @default.
- W2140228423 hasAuthorship W2140228423A5083821626 @default.
- W2140228423 hasConcept C131872663 @default.
- W2140228423 hasConcept C142724271 @default.
- W2140228423 hasConcept C16685009 @default.
- W2140228423 hasConcept C16930146 @default.
- W2140228423 hasConcept C172680121 @default.
- W2140228423 hasConcept C189165786 @default.
- W2140228423 hasConcept C2776953305 @default.
- W2140228423 hasConcept C2777495146 @default.
- W2140228423 hasConcept C2779234561 @default.
- W2140228423 hasConcept C2779742232 @default.
- W2140228423 hasConcept C2780197806 @default.
- W2140228423 hasConcept C2781385326 @default.
- W2140228423 hasConcept C2908647359 @default.
- W2140228423 hasConcept C54355233 @default.
- W2140228423 hasConcept C71924100 @default.
- W2140228423 hasConcept C86803240 @default.
- W2140228423 hasConcept C95444343 @default.
- W2140228423 hasConcept C99454951 @default.
- W2140228423 hasConceptScore W2140228423C131872663 @default.
- W2140228423 hasConceptScore W2140228423C142724271 @default.
- W2140228423 hasConceptScore W2140228423C16685009 @default.
- W2140228423 hasConceptScore W2140228423C16930146 @default.
- W2140228423 hasConceptScore W2140228423C172680121 @default.
- W2140228423 hasConceptScore W2140228423C189165786 @default.
- W2140228423 hasConceptScore W2140228423C2776953305 @default.
- W2140228423 hasConceptScore W2140228423C2777495146 @default.
- W2140228423 hasConceptScore W2140228423C2779234561 @default.
- W2140228423 hasConceptScore W2140228423C2779742232 @default.
- W2140228423 hasConceptScore W2140228423C2780197806 @default.
- W2140228423 hasConceptScore W2140228423C2781385326 @default.
- W2140228423 hasConceptScore W2140228423C2908647359 @default.
- W2140228423 hasConceptScore W2140228423C54355233 @default.
- W2140228423 hasConceptScore W2140228423C71924100 @default.
- W2140228423 hasConceptScore W2140228423C86803240 @default.
- W2140228423 hasConceptScore W2140228423C95444343 @default.
- W2140228423 hasConceptScore W2140228423C99454951 @default.
- W2140228423 hasIssue "1" @default.
- W2140228423 hasLocation W21402284231 @default.
- W2140228423 hasLocation W21402284232 @default.
- W2140228423 hasOpenAccess W2140228423 @default.
- W2140228423 hasPrimaryLocation W21402284231 @default.
- W2140228423 hasRelatedWork W2017861276 @default.
- W2140228423 hasRelatedWork W2027671904 @default.
- W2140228423 hasRelatedWork W2049014099 @default.