Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140243281> ?p ?o ?g. }
- W2140243281 endingPage "326" @default.
- W2140243281 startingPage "316" @default.
- W2140243281 abstract "We examined the potential protective effect of BDNF against β-amyloid-induced neurotoxicity in vitro and in vivo in rats. In neuronal cultures, BDNF had specific and dose–response protective effects on neuronal toxicity induced by Aβ 1–42 and Aβ 25–35 . It completely reversed the toxic action induced by Aβ 1–42 and partially that induced by Aβ 25–35 . These effects involved TrkB receptor activation since they were inhibited by K252a. Catalytic BDNF receptors (TrkB.FL) were localized in vitro in cortical neurons (mRNA and protein). In in vivo experiments, Aβ 25–35 was administered into the indusium griseum or the third ventricle and several parameters were measured 7 days later to evaluate potential Aβ 25–35 /BDNF interactions, i.e. local measurement of BDNF release, number of hippocampal hilar cells expressing SRIH mRNA and assessment of the corpus callosum damage (morphological examination, pyknotic nuclei counting and axon labeling with anti-MBP antibody). We conclude that BDNF possesses neuroprotective properties against toxic effects of Aβ peptides." @default.
- W2140243281 created "2016-06-24" @default.
- W2140243281 creator A5018135455 @default.
- W2140243281 creator A5022874714 @default.
- W2140243281 creator A5045510832 @default.
- W2140243281 creator A5045745526 @default.
- W2140243281 creator A5057590441 @default.
- W2140243281 creator A5059279866 @default.
- W2140243281 creator A5068560723 @default.
- W2140243281 date "2008-09-01" @default.
- W2140243281 modified "2023-10-17" @default.
- W2140243281 title "Protective effect of BDNF against beta-amyloid induced neurotoxicity in vitro and in vivo in rats" @default.
- W2140243281 cites W1500642137 @default.
- W2140243281 cites W1518752771 @default.
- W2140243281 cites W1531884888 @default.
- W2140243281 cites W1558527220 @default.
- W2140243281 cites W1575167357 @default.
- W2140243281 cites W1575626952 @default.
- W2140243281 cites W1642619469 @default.
- W2140243281 cites W1747922801 @default.
- W2140243281 cites W1960543132 @default.
- W2140243281 cites W1962835331 @default.
- W2140243281 cites W1965104729 @default.
- W2140243281 cites W1966734514 @default.
- W2140243281 cites W1967316112 @default.
- W2140243281 cites W1969048659 @default.
- W2140243281 cites W1970455232 @default.
- W2140243281 cites W1972163877 @default.
- W2140243281 cites W1973800714 @default.
- W2140243281 cites W1981545549 @default.
- W2140243281 cites W1982682488 @default.
- W2140243281 cites W1984795811 @default.
- W2140243281 cites W1991010898 @default.
- W2140243281 cites W1996681194 @default.
- W2140243281 cites W2003281302 @default.
- W2140243281 cites W2005561082 @default.
- W2140243281 cites W2006376420 @default.
- W2140243281 cites W2009520095 @default.
- W2140243281 cites W2016617827 @default.
- W2140243281 cites W2019087169 @default.
- W2140243281 cites W2023018045 @default.
- W2140243281 cites W2023500161 @default.
- W2140243281 cites W2025736105 @default.
- W2140243281 cites W2028181439 @default.
- W2140243281 cites W2030133426 @default.
- W2140243281 cites W2030879023 @default.
- W2140243281 cites W2031286114 @default.
- W2140243281 cites W2032920422 @default.
- W2140243281 cites W2033027472 @default.
- W2140243281 cites W2034863888 @default.
- W2140243281 cites W2039379548 @default.
- W2140243281 cites W2041285433 @default.
- W2140243281 cites W2042647735 @default.
- W2140243281 cites W2051314670 @default.
- W2140243281 cites W2055078523 @default.
- W2140243281 cites W2055979394 @default.
- W2140243281 cites W2057889532 @default.
- W2140243281 cites W2058096955 @default.
- W2140243281 cites W2059214757 @default.
- W2140243281 cites W2059507131 @default.
- W2140243281 cites W2067616890 @default.
- W2140243281 cites W2070202798 @default.
- W2140243281 cites W2078316783 @default.
- W2140243281 cites W2078989453 @default.
- W2140243281 cites W2079197070 @default.
- W2140243281 cites W2080288807 @default.
- W2140243281 cites W2081976133 @default.
- W2140243281 cites W2082317154 @default.
- W2140243281 cites W2086835104 @default.
- W2140243281 cites W2091316910 @default.
- W2140243281 cites W2094544368 @default.
- W2140243281 cites W2098557426 @default.
- W2140243281 cites W2098939947 @default.
- W2140243281 cites W2100467035 @default.
- W2140243281 cites W2100487936 @default.
- W2140243281 cites W2100665719 @default.
- W2140243281 cites W2113861132 @default.
- W2140243281 cites W2127027544 @default.
- W2140243281 cites W2134678910 @default.
- W2140243281 cites W2145748909 @default.
- W2140243281 cites W2149423990 @default.
- W2140243281 cites W2151986987 @default.
- W2140243281 cites W2159815723 @default.
- W2140243281 cites W2163639252 @default.
- W2140243281 cites W2386517867 @default.
- W2140243281 cites W71189737 @default.
- W2140243281 doi "https://doi.org/10.1016/j.nbd.2008.05.012" @default.
- W2140243281 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18585459" @default.
- W2140243281 hasPublicationYear "2008" @default.
- W2140243281 type Work @default.
- W2140243281 sameAs 2140243281 @default.
- W2140243281 citedByCount "265" @default.
- W2140243281 countsByYear W21402432812012 @default.
- W2140243281 countsByYear W21402432812013 @default.
- W2140243281 countsByYear W21402432812014 @default.
- W2140243281 countsByYear W21402432812015 @default.
- W2140243281 countsByYear W21402432812016 @default.
- W2140243281 countsByYear W21402432812017 @default.