Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140285293> ?p ?o ?g. }
- W2140285293 abstract "Fractures across the stages of chronic kidney disease (CKD) could be due to osteoporosis, some form of renal osteodystrophy defined by specific quantitative histomorphometry or chronic kidney disease-mineral and bone disorder (CKD-MBD). CKD-MBD is a systemic disease that links disorders of mineral and bone metabolism due to CKD to either one or all of the following: abnormalities of calcium, phosphorus, parathyroid hormone or vitamin D metabolism; abnormalities in bone turnover, mineralization, volume, linear growth or strength; or vascular or other soft-tissue calcification. Osteoporosis, as defined by the National Institutes of Health, may coexist with renal osteodystrophy or CKD-MBD. Differentiation among these disorders is required to manage correctly the correct disorder to reduce the risk of fractures. While the World Health Organization (WHO) bone mineral density (BMD) criteria for osteoporosis can be used in patients with stages 1-3 CKD, the disorders of bone turnover become so aberrant by stages 4 and 5 CKD that neither the WHO criteria nor the occurrence of a fragility fracture can be used for the diagnosis of osteoporosis. The diagnosis of osteoporosis in stages 4 and 5 CKD is one of the exclusion-excluding either renal osteodystrophy or CKD-MBD as the cause of low BMD or fragility fractures. Differentiations among the disorders of renal osteodystrophy, CKD-MBD or osteoporosis are dependent on the measurement of specific biochemical markers, including serum parathyroid hormone (PTH) and/or quantitative bone histomorphometry. Management of fractures in stages 1-3 CKD does not differ in persons with or without CKD with osteoporosis assuming that there is no evidence for CKD-MBD, clinically suspected by elevated PTH, hyperphosphatemia or fibroblast growth factor 23 due to CKD. Treatment of fractures in persons with osteoporosis and stages 4 and 5 CKD is not evidence-based, with the exception of post-hoc analysis suggesting efficacy and safety of specific osteoporosis therapies (alendronate, risedronate and denosumab) in stage 4 CKD. This review also discusses how to diagnose and manage fragility fractures across the five stages of CKD." @default.
- W2140285293 created "2016-06-24" @default.
- W2140285293 creator A5030361963 @default.
- W2140285293 date "2014-12-23" @default.
- W2140285293 modified "2023-10-08" @default.
- W2140285293 title "Chronic kidney disease and the skeleton" @default.
- W2140285293 cites W1257766419 @default.
- W2140285293 cites W1495535606 @default.
- W2140285293 cites W1506400640 @default.
- W2140285293 cites W1513343391 @default.
- W2140285293 cites W1548081233 @default.
- W2140285293 cites W1698027715 @default.
- W2140285293 cites W175660244 @default.
- W2140285293 cites W1842491230 @default.
- W2140285293 cites W1923735816 @default.
- W2140285293 cites W1948301689 @default.
- W2140285293 cites W1966953695 @default.
- W2140285293 cites W1967218936 @default.
- W2140285293 cites W1970214915 @default.
- W2140285293 cites W1971384336 @default.
- W2140285293 cites W1971488797 @default.
- W2140285293 cites W1973661281 @default.
- W2140285293 cites W1979904085 @default.
- W2140285293 cites W1981997645 @default.
- W2140285293 cites W1983211249 @default.
- W2140285293 cites W1985681780 @default.
- W2140285293 cites W1986314931 @default.
- W2140285293 cites W1990729029 @default.
- W2140285293 cites W1990771263 @default.
- W2140285293 cites W1992159640 @default.
- W2140285293 cites W1992836905 @default.
- W2140285293 cites W1993110501 @default.
- W2140285293 cites W1994313426 @default.
- W2140285293 cites W1995846491 @default.
- W2140285293 cites W1997839478 @default.
- W2140285293 cites W1999334373 @default.
- W2140285293 cites W1999498384 @default.
- W2140285293 cites W2004855713 @default.
- W2140285293 cites W2005359013 @default.
- W2140285293 cites W2005779589 @default.
- W2140285293 cites W2005942803 @default.
- W2140285293 cites W2007731390 @default.
- W2140285293 cites W2008293421 @default.
- W2140285293 cites W2011822533 @default.
- W2140285293 cites W2011828467 @default.
- W2140285293 cites W2012820109 @default.
- W2140285293 cites W2014026700 @default.
- W2140285293 cites W2015350578 @default.
- W2140285293 cites W2018901137 @default.
- W2140285293 cites W2019582558 @default.
- W2140285293 cites W2020813947 @default.
- W2140285293 cites W2021465534 @default.
- W2140285293 cites W2026962530 @default.
- W2140285293 cites W2029915743 @default.
- W2140285293 cites W2030726233 @default.
- W2140285293 cites W2031567798 @default.
- W2140285293 cites W2033727062 @default.
- W2140285293 cites W2034451046 @default.
- W2140285293 cites W2034953297 @default.
- W2140285293 cites W2034993464 @default.
- W2140285293 cites W2035071845 @default.
- W2140285293 cites W2035749891 @default.
- W2140285293 cites W2036688640 @default.
- W2140285293 cites W2037036094 @default.
- W2140285293 cites W2038821938 @default.
- W2140285293 cites W2039712973 @default.
- W2140285293 cites W2040156285 @default.
- W2140285293 cites W2041598849 @default.
- W2140285293 cites W2042007405 @default.
- W2140285293 cites W2042353520 @default.
- W2140285293 cites W2043368155 @default.
- W2140285293 cites W2043575472 @default.
- W2140285293 cites W2045936444 @default.
- W2140285293 cites W2046983926 @default.
- W2140285293 cites W2055233141 @default.
- W2140285293 cites W2056335391 @default.
- W2140285293 cites W2057649851 @default.
- W2140285293 cites W2057930208 @default.
- W2140285293 cites W2061186448 @default.
- W2140285293 cites W2077170129 @default.
- W2140285293 cites W2078329340 @default.
- W2140285293 cites W2078865928 @default.
- W2140285293 cites W2079154720 @default.
- W2140285293 cites W2079930274 @default.
- W2140285293 cites W2083011022 @default.
- W2140285293 cites W2085739273 @default.
- W2140285293 cites W2086216113 @default.
- W2140285293 cites W2087378917 @default.
- W2140285293 cites W2087929119 @default.
- W2140285293 cites W2088735294 @default.
- W2140285293 cites W2089074208 @default.
- W2140285293 cites W2091681526 @default.
- W2140285293 cites W2093020381 @default.
- W2140285293 cites W2095219104 @default.
- W2140285293 cites W2095440374 @default.
- W2140285293 cites W2096425957 @default.
- W2140285293 cites W2096627331 @default.
- W2140285293 cites W2097566614 @default.
- W2140285293 cites W2098907214 @default.
- W2140285293 cites W2102950420 @default.