Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140292786> ?p ?o ?g. }
- W2140292786 endingPage "3543" @default.
- W2140292786 startingPage "3529" @default.
- W2140292786 abstract "Fbxo45 is an F-box protein that is restricted to the nervous system. Unlike other F-box proteins, Fbxo45 was found not to form an SCF complex as a result of an amino acid substitution in the consensus sequence for Cul1 binding. Proteomics analysis revealed that Fbxo45 specifically associates with PAM (protein associated with Myc), a RING finger-type ubiquitin ligase. Mice deficient in Fbxo45 were generated and found to die soon after birth as a result of respiratory distress. Fbxo45(-)(/)(-) embryos show abnormal innervation of the diaphragm, impaired synapse formation at neuromuscular junctions, and aberrant development of axon fiber tracts in the brain. Similar defects are also observed in mice lacking Phr1 (mouse ortholog of PAM), suggesting that Fbxo45 and Phr1 function in the same pathway. In addition, neuronal migration was impaired in Fbxo45(-)(/)(-) mice. These results suggest that Fbxo45 forms a novel Fbxo45-PAM ubiquitin ligase complex that plays an important role in neural development." @default.
- W2140292786 created "2016-06-24" @default.
- W2140292786 creator A5001196940 @default.
- W2140292786 creator A5006144232 @default.
- W2140292786 creator A5011292373 @default.
- W2140292786 creator A5035479034 @default.
- W2140292786 creator A5037804232 @default.
- W2140292786 creator A5043931681 @default.
- W2140292786 creator A5044700950 @default.
- W2140292786 date "2009-07-01" @default.
- W2140292786 modified "2023-09-25" @default.
- W2140292786 title "Fbxo45 Forms a Novel Ubiquitin Ligase Complex and Is Required for Neuronal Development" @default.
- W2140292786 cites W1556426653 @default.
- W2140292786 cites W1594952503 @default.
- W2140292786 cites W1780544763 @default.
- W2140292786 cites W1967445973 @default.
- W2140292786 cites W1970430170 @default.
- W2140292786 cites W1975974821 @default.
- W2140292786 cites W1986951078 @default.
- W2140292786 cites W2001443225 @default.
- W2140292786 cites W2005735676 @default.
- W2140292786 cites W2007252839 @default.
- W2140292786 cites W2011005136 @default.
- W2140292786 cites W2013317474 @default.
- W2140292786 cites W2016627742 @default.
- W2140292786 cites W2017688356 @default.
- W2140292786 cites W2022661750 @default.
- W2140292786 cites W2040357332 @default.
- W2140292786 cites W2046071339 @default.
- W2140292786 cites W2046141144 @default.
- W2140292786 cites W2055038449 @default.
- W2140292786 cites W2055892514 @default.
- W2140292786 cites W2060552444 @default.
- W2140292786 cites W2061156149 @default.
- W2140292786 cites W2063263218 @default.
- W2140292786 cites W2076541146 @default.
- W2140292786 cites W2084367357 @default.
- W2140292786 cites W2088760718 @default.
- W2140292786 cites W2092488650 @default.
- W2140292786 cites W2094119136 @default.
- W2140292786 cites W2094859123 @default.
- W2140292786 cites W2099421316 @default.
- W2140292786 cites W2101539258 @default.
- W2140292786 cites W2102628825 @default.
- W2140292786 cites W2107964063 @default.
- W2140292786 cites W2110520657 @default.
- W2140292786 cites W2121077625 @default.
- W2140292786 cites W2130040193 @default.
- W2140292786 cites W2134505400 @default.
- W2140292786 cites W2134630325 @default.
- W2140292786 cites W2140158862 @default.
- W2140292786 cites W2144993348 @default.
- W2140292786 cites W2151686210 @default.
- W2140292786 cites W2162499463 @default.
- W2140292786 cites W2166987747 @default.
- W2140292786 cites W2170147898 @default.
- W2140292786 cites W2170787873 @default.
- W2140292786 cites W2177590001 @default.
- W2140292786 cites W2790805946 @default.
- W2140292786 doi "https://doi.org/10.1128/mcb.00364-09" @default.
- W2140292786 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2698766" @default.
- W2140292786 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19398581" @default.
- W2140292786 hasPublicationYear "2009" @default.
- W2140292786 type Work @default.
- W2140292786 sameAs 2140292786 @default.
- W2140292786 citedByCount "105" @default.
- W2140292786 countsByYear W21402927862012 @default.
- W2140292786 countsByYear W21402927862013 @default.
- W2140292786 countsByYear W21402927862014 @default.
- W2140292786 countsByYear W21402927862015 @default.
- W2140292786 countsByYear W21402927862016 @default.
- W2140292786 countsByYear W21402927862017 @default.
- W2140292786 countsByYear W21402927862018 @default.
- W2140292786 countsByYear W21402927862019 @default.
- W2140292786 countsByYear W21402927862020 @default.
- W2140292786 countsByYear W21402927862021 @default.
- W2140292786 countsByYear W21402927862022 @default.
- W2140292786 countsByYear W21402927862023 @default.
- W2140292786 crossrefType "journal-article" @default.
- W2140292786 hasAuthorship W2140292786A5001196940 @default.
- W2140292786 hasAuthorship W2140292786A5006144232 @default.
- W2140292786 hasAuthorship W2140292786A5011292373 @default.
- W2140292786 hasAuthorship W2140292786A5035479034 @default.
- W2140292786 hasAuthorship W2140292786A5037804232 @default.
- W2140292786 hasAuthorship W2140292786A5043931681 @default.
- W2140292786 hasAuthorship W2140292786A5044700950 @default.
- W2140292786 hasBestOaLocation W21402927861 @default.
- W2140292786 hasConcept C104317684 @default.
- W2140292786 hasConcept C129536746 @default.
- W2140292786 hasConcept C134459356 @default.
- W2140292786 hasConcept C169760540 @default.
- W2140292786 hasConcept C175114707 @default.
- W2140292786 hasConcept C192586883 @default.
- W2140292786 hasConcept C196843134 @default.
- W2140292786 hasConcept C25602115 @default.
- W2140292786 hasConcept C2779530196 @default.
- W2140292786 hasConcept C54355233 @default.
- W2140292786 hasConcept C545706735 @default.