Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140305725> ?p ?o ?g. }
- W2140305725 endingPage "57" @default.
- W2140305725 startingPage "52" @default.
- W2140305725 abstract "Acquired genetic alterations such as balanced and unbalanced chromosome aberrations and submicroscopic gene mutations and changes in gene expression strongly affect pretreatment features and prognosis of adults with acute myeloid leukemia (AML). The most frequent chromosome/molecular rearrangements, that is, t(8;21)(q22;q22)/RUNX1-RUNX1T1 and inv(16)(p13q22)/t(16;16)(p13;q22)/CBFB-MYH11 characteristic of core-binding factor (CBF) AML and t(15;17)(q22;q12∼21)/PML-RARA characteristic of acute promyelocytic leukemia (APL), confer favorable clinical outcome when patients receive optimal treatment, that is, regimens that include high-dose cytarabine for CBF AML and all-trans-retinoic acid and/or arsenic trioxide for APL. Recently, mutations in such genes as KIT in CBF AML and FLT3 in APL have been correlated with clinical features and/or outcome of patients with these AML subtypes, and microarray gene expression profiling has been successfully used for diagnostic purposes and to provide biologic insights. These data underscore the value of genetic testing for common translocations for diagnosis, prognostication, and, increasingly, selecting therapy in acute leukemia." @default.
- W2140305725 created "2016-06-24" @default.
- W2140305725 creator A5062108544 @default.
- W2140305725 creator A5076516238 @default.
- W2140305725 date "2008-07-01" @default.
- W2140305725 modified "2023-10-13" @default.
- W2140305725 title "Clinical Significance of the Most Common Chromosome Translocations in Adult Acute Myeloid Leukemia" @default.
- W2140305725 cites W1492609361 @default.
- W2140305725 cites W1524671781 @default.
- W2140305725 cites W1533510727 @default.
- W2140305725 cites W1568588547 @default.
- W2140305725 cites W1930980342 @default.
- W2140305725 cites W1977747092 @default.
- W2140305725 cites W1988080543 @default.
- W2140305725 cites W1988676466 @default.
- W2140305725 cites W1991509879 @default.
- W2140305725 cites W1991888670 @default.
- W2140305725 cites W1995369623 @default.
- W2140305725 cites W1998548135 @default.
- W2140305725 cites W2001340877 @default.
- W2140305725 cites W2013967591 @default.
- W2140305725 cites W2039117329 @default.
- W2140305725 cites W2043304547 @default.
- W2140305725 cites W2045166052 @default.
- W2140305725 cites W2047591593 @default.
- W2140305725 cites W2059340669 @default.
- W2140305725 cites W2063107989 @default.
- W2140305725 cites W2074453573 @default.
- W2140305725 cites W2076638971 @default.
- W2140305725 cites W2078558699 @default.
- W2140305725 cites W2094912768 @default.
- W2140305725 cites W2096202228 @default.
- W2140305725 cites W2100663913 @default.
- W2140305725 cites W2103513114 @default.
- W2140305725 cites W2109653033 @default.
- W2140305725 cites W2110502951 @default.
- W2140305725 cites W2110828128 @default.
- W2140305725 cites W2125960056 @default.
- W2140305725 cites W2138069312 @default.
- W2140305725 cites W2148047805 @default.
- W2140305725 cites W2155376978 @default.
- W2140305725 cites W2158872718 @default.
- W2140305725 cites W2162700652 @default.
- W2140305725 cites W2162872669 @default.
- W2140305725 cites W2164238912 @default.
- W2140305725 cites W2165795761 @default.
- W2140305725 cites W2244261822 @default.
- W2140305725 cites W2302725568 @default.
- W2140305725 cites W2893539009 @default.
- W2140305725 cites W4234755708 @default.
- W2140305725 doi "https://doi.org/10.1093/jncimonographs/lgn003" @default.
- W2140305725 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18648004" @default.
- W2140305725 hasPublicationYear "2008" @default.
- W2140305725 type Work @default.
- W2140305725 sameAs 2140305725 @default.
- W2140305725 citedByCount "45" @default.
- W2140305725 countsByYear W21403057252012 @default.
- W2140305725 countsByYear W21403057252013 @default.
- W2140305725 countsByYear W21403057252014 @default.
- W2140305725 countsByYear W21403057252015 @default.
- W2140305725 countsByYear W21403057252016 @default.
- W2140305725 countsByYear W21403057252017 @default.
- W2140305725 countsByYear W21403057252018 @default.
- W2140305725 countsByYear W21403057252019 @default.
- W2140305725 countsByYear W21403057252020 @default.
- W2140305725 countsByYear W21403057252021 @default.
- W2140305725 countsByYear W21403057252022 @default.
- W2140305725 countsByYear W21403057252023 @default.
- W2140305725 crossrefType "journal-article" @default.
- W2140305725 hasAuthorship W2140305725A5062108544 @default.
- W2140305725 hasAuthorship W2140305725A5076516238 @default.
- W2140305725 hasBestOaLocation W21403057251 @default.
- W2140305725 hasConcept C104317684 @default.
- W2140305725 hasConcept C126322002 @default.
- W2140305725 hasConcept C138626823 @default.
- W2140305725 hasConcept C143998085 @default.
- W2140305725 hasConcept C190283241 @default.
- W2140305725 hasConcept C2776601000 @default.
- W2140305725 hasConcept C2778041864 @default.
- W2140305725 hasConcept C2778193527 @default.
- W2140305725 hasConcept C2778220731 @default.
- W2140305725 hasConcept C2778461978 @default.
- W2140305725 hasConcept C2778729363 @default.
- W2140305725 hasConcept C2780386689 @default.
- W2140305725 hasConcept C2781121885 @default.
- W2140305725 hasConcept C502942594 @default.
- W2140305725 hasConcept C54355233 @default.
- W2140305725 hasConcept C71924100 @default.
- W2140305725 hasConcept C86339819 @default.
- W2140305725 hasConcept C86803240 @default.
- W2140305725 hasConceptScore W2140305725C104317684 @default.
- W2140305725 hasConceptScore W2140305725C126322002 @default.
- W2140305725 hasConceptScore W2140305725C138626823 @default.
- W2140305725 hasConceptScore W2140305725C143998085 @default.
- W2140305725 hasConceptScore W2140305725C190283241 @default.
- W2140305725 hasConceptScore W2140305725C2776601000 @default.
- W2140305725 hasConceptScore W2140305725C2778041864 @default.
- W2140305725 hasConceptScore W2140305725C2778193527 @default.