FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140314545> ?p ?o ?g. }

• W2140314545 endingPage "30" @default.
• W2140314545 startingPage "23" @default.
• W2140314545 abstract "Kinins are released during dermal injury and inflammation and seem to contribute to the pathogenesis of cutaneous diseases.Participation of kinins in skin inflammatory process was evaluated using knockout mice and non-peptide kinin receptor antagonists.Chronic skin inflammation was induced by multiple applications of TPA in mice ear.The B(2) knockout mice (B(2)(-/-)) showed a significant increase of ear weight (23 ± 10%) and epidermal cellular hyperproliferation and acanthosis formation upon histological analysis when compared with wildtype mice. Also, evaluation of PCNA levels by Western blot and immunohistochemistry confirmed the increase in the epidermis hyperproliferation in the ear skin of B(2)(-/-) mice. In contrast, no modification in these parameters was detected in B(1) knockout mice (B(1)(-/-)). However, mice lacking both kinin receptors (B(1)B(2)(-/-)) presented a considerable reduction of epidermis thickness and in PCNA levels. Following the establishment of skin inflammation (5th day of TPA application) treatment with the non-peptide antagonists SSR 240612 (B(1) receptor antagonist), FR 173657 (B(2) receptor antagonist), or SSR 240612 plus FR 173657 topically applied, caused a significant inhibition of ear weight (20 ± 5%, 34 ± 4% and 32 ± 6%, respectively). In the histological analysis, the antagonists produced a reduction in epidermal hyperplasia and acanthosis formation; but the treatment with a combination of the two antagonists did not increase efficacy.Kinin receptors seem to be involved in the control of the keratinocyte hyperproliferative process, and non-peptide kinin receptor antagonists may be useful tools in the treatment of hyperproliferative skin disorders." @default.
• W2140314545 created "2016-06-24" @default.
• W2140314545 creator A5005125196 @default.
• W2140314545 creator A5020555504 @default.
• W2140314545 creator A5024398009 @default.
• W2140314545 creator A5025503952 @default.
• W2140314545 creator A5038260780 @default.
• W2140314545 creator A5038290965 @default.
• W2140314545 creator A5039371456 @default.
• W2140314545 creator A5039434027 @default.
• W2140314545 creator A5056242920 @default.
• W2140314545 creator A5068625450 @default.
• W2140314545 creator A5071123304 @default.
• W2140314545 creator A5091005335 @default.
• W2140314545 creator A5058097788 @default.
• W2140314545 date "2011-10-01" @default.
• W2140314545 modified "2023-09-30" @default.
• W2140314545 title "B1 and B2 kinin receptor participation in hyperproliferative and inflammatory skin processes in mice" @default.
• W2140314545 cites W1974218877 @default.
• W2140314545 cites W1979736472 @default.
• W2140314545 cites W1986268987 @default.
• W2140314545 cites W2009199215 @default.
• W2140314545 cites W2011923274 @default.
• W2140314545 cites W2032806645 @default.
• W2140314545 cites W2033155819 @default.
• W2140314545 cites W2034840085 @default.
• W2140314545 cites W2035276787 @default.
• W2140314545 cites W2041567385 @default.
• W2140314545 cites W2041792789 @default.
• W2140314545 cites W2046605450 @default.
• W2140314545 cites W2057060327 @default.
• W2140314545 cites W2057531773 @default.
• W2140314545 cites W2075375417 @default.
• W2140314545 cites W2079116886 @default.
• W2140314545 cites W2080090843 @default.
• W2140314545 cites W2081673243 @default.
• W2140314545 cites W2091877422 @default.
• W2140314545 cites W2115565372 @default.
• W2140314545 cites W2128407895 @default.
• W2140314545 cites W2134556162 @default.
• W2140314545 cites W2134668392 @default.
• W2140314545 cites W2148390754 @default.
• W2140314545 cites W2165715168 @default.
• W2140314545 cites W2171982271 @default.
• W2140314545 cites W4233561050 @default.
• W2140314545 doi "https://doi.org/10.1016/j.jdermsci.2011.06.016" @default.
• W2140314545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21840178" @default.
• W2140314545 hasPublicationYear "2011" @default.
• W2140314545 type Work @default.
• W2140314545 sameAs 2140314545 @default.
• W2140314545 citedByCount "17" @default.
• W2140314545 countsByYear W21403145452012 @default.
• W2140314545 countsByYear W21403145452013 @default.
• W2140314545 countsByYear W21403145452014 @default.
• W2140314545 countsByYear W21403145452015 @default.
• W2140314545 countsByYear W21403145452016 @default.
• W2140314545 countsByYear W21403145452017 @default.
• W2140314545 countsByYear W21403145452020 @default.
• W2140314545 countsByYear W21403145452021 @default.
• W2140314545 countsByYear W21403145452022 @default.
• W2140314545 crossrefType "journal-article" @default.
• W2140314545 hasAuthorship W2140314545A5005125196 @default.
• W2140314545 hasAuthorship W2140314545A5020555504 @default.
• W2140314545 hasAuthorship W2140314545A5024398009 @default.
• W2140314545 hasAuthorship W2140314545A5025503952 @default.
• W2140314545 hasAuthorship W2140314545A5038260780 @default.
• W2140314545 hasAuthorship W2140314545A5038290965 @default.
• W2140314545 hasAuthorship W2140314545A5039371456 @default.
• W2140314545 hasAuthorship W2140314545A5039434027 @default.
• W2140314545 hasAuthorship W2140314545A5056242920 @default.
• W2140314545 hasAuthorship W2140314545A5058097788 @default.
• W2140314545 hasAuthorship W2140314545A5068625450 @default.
• W2140314545 hasAuthorship W2140314545A5071123304 @default.
• W2140314545 hasAuthorship W2140314545A5091005335 @default.
• W2140314545 hasConcept C105702510 @default.
• W2140314545 hasConcept C126322002 @default.
• W2140314545 hasConcept C134018914 @default.
• W2140314545 hasConcept C142724271 @default.
• W2140314545 hasConcept C170493617 @default.
• W2140314545 hasConcept C182704531 @default.
• W2140314545 hasConcept C202751555 @default.
• W2140314545 hasConcept C203014093 @default.
• W2140314545 hasConcept C204232928 @default.
• W2140314545 hasConcept C2776246183 @default.
• W2140314545 hasConcept C2776458125 @default.
• W2140314545 hasConcept C2776885963 @default.
• W2140314545 hasConcept C2776914184 @default.
• W2140314545 hasConcept C2777074287 @default.
• W2140314545 hasConcept C2778122271 @default.
• W2140314545 hasConcept C2778478263 @default.
• W2140314545 hasConcept C2779591629 @default.
• W2140314545 hasConcept C2779915019 @default.
• W2140314545 hasConcept C34688535 @default.
• W2140314545 hasConcept C55493867 @default.
• W2140314545 hasConcept C71924100 @default.
• W2140314545 hasConcept C86803240 @default.
• W2140314545 hasConceptScore W2140314545C105702510 @default.
• W2140314545 hasConceptScore W2140314545C126322002 @default.

• next