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- W2140319216 abstract "DNA damage response (DDR) and the centrosome cycle are two of the most critical processes for maintaining a stable genome in animals. Sporadic evidence suggests a connection between these two processes. Here, we report our findings that six Fanconi Anemia (FA) proteins, including FancI and FancJ, localize to the centrosome. Intriguingly, we found that the localization of FancJ to the mother centrosome is stimulated by a DNA interstrand crosslinker, Mitomycin C (MMC). We further show that, in addition to its role in interstrand crosslinking (ICL) repair, FancJ also regulates the normal centrosome cycle as well as ICL induced centrosome amplification by activating the polo-like kinase 1 (PLK1). We have uncovered a novel function of FancJ in centrosome biogenesis and established centrosome amplification as an integral part of the ICL response." @default.
- W2140319216 created "2016-06-24" @default.
- W2140319216 creator A5001916708 @default.
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- W2140319216 creator A5057815689 @default.
- W2140319216 creator A5064803348 @default.
- W2140319216 creator A5085520781 @default.
- W2140319216 date "2013-08-06" @default.
- W2140319216 modified "2023-09-23" @default.
- W2140319216 title "FancJ regulates interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1" @default.
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- W2140319216 cites W1963759286 @default.
- W2140319216 cites W1963874300 @default.
- W2140319216 cites W1968438075 @default.
- W2140319216 cites W1973965906 @default.
- W2140319216 cites W1979324654 @default.
- W2140319216 cites W1980676055 @default.
- W2140319216 cites W1982046131 @default.
- W2140319216 cites W1988156733 @default.
- W2140319216 cites W1989800108 @default.
- W2140319216 cites W1994015040 @default.
- W2140319216 cites W1994488152 @default.
- W2140319216 cites W2006401070 @default.
- W2140319216 cites W2015805015 @default.
- W2140319216 cites W2019013949 @default.
- W2140319216 cites W2023510116 @default.
- W2140319216 cites W2024131694 @default.
- W2140319216 cites W2029108033 @default.
- W2140319216 cites W2029405204 @default.
- W2140319216 cites W2033267768 @default.
- W2140319216 cites W2037874673 @default.
- W2140319216 cites W2038747158 @default.
- W2140319216 cites W2039220621 @default.
- W2140319216 cites W2039800080 @default.
- W2140319216 cites W2042146481 @default.
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- W2140319216 cites W2056164302 @default.
- W2140319216 cites W2058232728 @default.
- W2140319216 cites W2058336798 @default.
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- W2140319216 cites W2060387325 @default.
- W2140319216 cites W2066362104 @default.
- W2140319216 cites W2067087347 @default.
- W2140319216 cites W2068759324 @default.
- W2140319216 cites W2072637746 @default.
- W2140319216 cites W2077436902 @default.
- W2140319216 cites W2080823011 @default.
- W2140319216 cites W2081201480 @default.
- W2140319216 cites W2102647168 @default.
- W2140319216 cites W2109173575 @default.
- W2140319216 cites W2109903344 @default.
- W2140319216 cites W2110817748 @default.
- W2140319216 cites W2114776482 @default.
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- W2140319216 cites W2126117361 @default.
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- W2140319216 cites W2131837045 @default.
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- W2140319216 cites W2134590240 @default.
- W2140319216 cites W2135212986 @default.
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- W2140319216 cites W2141725799 @default.
- W2140319216 cites W2155774293 @default.
- W2140319216 cites W2157443774 @default.
- W2140319216 cites W2159243681 @default.
- W2140319216 cites W2161090683 @default.
- W2140319216 cites W2161990527 @default.
- W2140319216 cites W2164890615 @default.
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- W2140319216 doi "https://doi.org/10.1242/bio.20135801" @default.
- W2140319216 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3798185" @default.
- W2140319216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24167712" @default.
- W2140319216 hasPublicationYear "2013" @default.
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