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- W2140321071 endingPage "CIN.S6631" @default.
- W2140321071 startingPage "CIN.S6631" @default.
- W2140321071 abstract "Aberrant microRNA activity has been reported in many diseases, and studies often find numerous microRNAs concurrently dysregulated. Most target genes have binding sites for multiple microRNAs, and mounting evidence indicates that it is important to consider their combinatorial effect on target gene repression. A recent study associated the coincident loss of expression of six microRNAs with metastatic potential in breast cancer. Here, we used a new computational method, miR-AT!, to investigate combinatorial activity among this group of microRNAs. We found that the set of transcripts having multiple target sites for these microRNAs was significantly enriched with genes involved in cellular processes commonly perturbed in metastatic tumors: cell cycle regulation, cytoskeleton organization, and cell adhesion. Network analysis revealed numerous target genes upstream of cyclin D1 and c-Myc, indicating that the collective loss of the six microRNAs may have a focal effect on these two key regulatory nodes. A number of genes previously implicated in cancer metastasis are among the predicted combinatorial targets, including TGFB1, ARPC3, and RANKL. In summary, our analysis reveals extensive combinatorial interactions that have notable implications for their potential role in breast cancer metastasis and in therapeutic development." @default.
- W2140321071 created "2016-06-24" @default.
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- W2140321071 creator A5077690280 @default.
- W2140321071 date "2011-01-01" @default.
- W2140321071 modified "2023-10-01" @default.
- W2140321071 title "In silico Analysis of Combinatorial microRNA Activity Reveals Target Genes and Pathways Associated with Breast Cancer Metastasis" @default.
- W2140321071 cites W144423133 @default.
- W2140321071 cites W1556472699 @default.
- W2140321071 cites W1593929303 @default.
- W2140321071 cites W1767395388 @default.
- W2140321071 cites W1840010921 @default.
- W2140321071 cites W1964770292 @default.
- W2140321071 cites W1968056944 @default.
- W2140321071 cites W1969504285 @default.
- W2140321071 cites W1974114904 @default.
- W2140321071 cites W1975390562 @default.
- W2140321071 cites W1977218806 @default.
- W2140321071 cites W1985286473 @default.
- W2140321071 cites W1993324010 @default.
- W2140321071 cites W1993331605 @default.
- W2140321071 cites W1993799748 @default.
- W2140321071 cites W1997158304 @default.
- W2140321071 cites W2005156019 @default.
- W2140321071 cites W2006348395 @default.
- W2140321071 cites W2017818235 @default.
- W2140321071 cites W2019004412 @default.
- W2140321071 cites W2028292919 @default.
- W2140321071 cites W2032148033 @default.
- W2140321071 cites W2034538165 @default.
- W2140321071 cites W2035232812 @default.
- W2140321071 cites W2039528004 @default.
- W2140321071 cites W2040906663 @default.
- W2140321071 cites W2044832480 @default.
- W2140321071 cites W2044848363 @default.
- W2140321071 cites W2049868101 @default.
- W2140321071 cites W2051255001 @default.
- W2140321071 cites W2058194607 @default.
- W2140321071 cites W2063422908 @default.
- W2140321071 cites W2070413050 @default.
- W2140321071 cites W2072451938 @default.
- W2140321071 cites W2073388400 @default.
- W2140321071 cites W2075475045 @default.
- W2140321071 cites W2076760492 @default.
- W2140321071 cites W2076984671 @default.
- W2140321071 cites W2082833890 @default.
- W2140321071 cites W2083035492 @default.
- W2140321071 cites W2086491566 @default.
- W2140321071 cites W2090513951 @default.
- W2140321071 cites W2091288043 @default.
- W2140321071 cites W2092614678 @default.
- W2140321071 cites W2094048386 @default.
- W2140321071 cites W2096436239 @default.
- W2140321071 cites W2100285612 @default.
- W2140321071 cites W2106439426 @default.
- W2140321071 cites W2109136664 @default.
- W2140321071 cites W2112192177 @default.
- W2140321071 cites W2113468928 @default.
- W2140321071 cites W2117116688 @default.
- W2140321071 cites W2117539984 @default.
- W2140321071 cites W2119912419 @default.
- W2140321071 cites W2120456037 @default.
- W2140321071 cites W2122078080 @default.
- W2140321071 cites W2122555310 @default.
- W2140321071 cites W2122683221 @default.
- W2140321071 cites W2123005692 @default.
- W2140321071 cites W2136257629 @default.
- W2140321071 cites W2138369573 @default.
- W2140321071 cites W2139342290 @default.
- W2140321071 cites W2140224974 @default.
- W2140321071 cites W2148229838 @default.
- W2140321071 cites W2153090726 @default.
- W2140321071 cites W2153562609 @default.
- W2140321071 cites W2153933760 @default.
- W2140321071 cites W2154264025 @default.
- W2140321071 cites W2155802295 @default.
- W2140321071 cites W2159686118 @default.
- W2140321071 cites W2161473299 @default.
- W2140321071 cites W2164847396 @default.
- W2140321071 cites W2165279394 @default.
- W2140321071 cites W2166240615 @default.
- W2140321071 cites W2167568301 @default.
- W2140321071 cites W2171559697 @default.
- W2140321071 cites W2172186946 @default.
- W2140321071 cites W2312524270 @default.
- W2140321071 cites W2401522950 @default.
- W2140321071 doi "https://doi.org/10.4137/cin.s6631" @default.
- W2140321071 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3085424" @default.
- W2140321071 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21552493" @default.
- W2140321071 hasPublicationYear "2011" @default.
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