Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140321502> ?p ?o ?g. }
- W2140321502 endingPage "096" @default.
- W2140321502 startingPage "086" @default.
- W2140321502 abstract "Macrophages play a key role in the inflammatory reaction of body defense. It has been demonstrated that there are various types of macrophages and their function greatly affects the progressive conditions of inflammation process. The objective of this study is to develop a drug delivery system (DDS) which can modify the biological function of macrophages. Pioglitazone (Pio) of water-insolubility was water-solubilized by the micelle formation with gelatin grafted with L-lactic acid oligomer (Pio-micelles). The Pio water-solubilized was incorporated into a biodegradable gelatin hydrogel. The experiments of Pio release and hydrogel degradation revealed that pio was released from the hydrogel incorporating Pio-micelles in vitro and in vivo. The Pio-micelles and Pio allowed macrophages to enhance the mRNA expression level of arginase1 which is a measurement of type 2 macrophages. When applied to a skin defect model of mice, the hydrogels incorporating Pio-micelles enhanced the arginase1 level around the site implanted to a significant great extent compared with the Pio solution. The Pio release technique is promising to modify the phenotype of macrophages." @default.
- W2140321502 created "2016-06-24" @default.
- W2140321502 creator A5019792391 @default.
- W2140321502 creator A5050230312 @default.
- W2140321502 creator A5055033211 @default.
- W2140321502 creator A5084023342 @default.
- W2140321502 date "2015-01-01" @default.
- W2140321502 modified "2023-10-11" @default.
- W2140321502 title "Controlled release of pioglitazone from biodegradable hydrogels to modify macrophages phenotype" @default.
- W2140321502 cites W1550364580 @default.
- W2140321502 cites W1579094233 @default.
- W2140321502 cites W1971248512 @default.
- W2140321502 cites W1973096997 @default.
- W2140321502 cites W1979761686 @default.
- W2140321502 cites W1997549639 @default.
- W2140321502 cites W2001717792 @default.
- W2140321502 cites W2009170266 @default.
- W2140321502 cites W2015141049 @default.
- W2140321502 cites W2023166018 @default.
- W2140321502 cites W2023459898 @default.
- W2140321502 cites W2025058399 @default.
- W2140321502 cites W2025111444 @default.
- W2140321502 cites W2028189923 @default.
- W2140321502 cites W2028543411 @default.
- W2140321502 cites W2031066979 @default.
- W2140321502 cites W2031939102 @default.
- W2140321502 cites W2033204507 @default.
- W2140321502 cites W2034795794 @default.
- W2140321502 cites W2037598347 @default.
- W2140321502 cites W2038689279 @default.
- W2140321502 cites W2040055558 @default.
- W2140321502 cites W2047591801 @default.
- W2140321502 cites W2054472394 @default.
- W2140321502 cites W2054726115 @default.
- W2140321502 cites W2055901626 @default.
- W2140321502 cites W2065210647 @default.
- W2140321502 cites W2079080809 @default.
- W2140321502 cites W2082492482 @default.
- W2140321502 cites W2091360431 @default.
- W2140321502 cites W2093705034 @default.
- W2140321502 cites W2095400574 @default.
- W2140321502 cites W2095595707 @default.
- W2140321502 cites W2107752044 @default.
- W2140321502 cites W2123659126 @default.
- W2140321502 cites W2124798272 @default.
- W2140321502 cites W2133146690 @default.
- W2140321502 cites W2133941138 @default.
- W2140321502 cites W2137178267 @default.
- W2140321502 cites W2141559778 @default.
- W2140321502 cites W2159442019 @default.
- W2140321502 cites W2163175900 @default.
- W2140321502 cites W2164397416 @default.
- W2140321502 cites W2172914696 @default.
- W2140321502 cites W2210503175 @default.
- W2140321502 cites W2323271314 @default.
- W2140321502 cites W2325727928 @default.
- W2140321502 cites W2330109819 @default.
- W2140321502 cites W2335922553 @default.
- W2140321502 cites W2397636647 @default.
- W2140321502 doi "https://doi.org/10.2492/inflammregen.35.086" @default.
- W2140321502 hasPublicationYear "2015" @default.
- W2140321502 type Work @default.
- W2140321502 sameAs 2140321502 @default.
- W2140321502 citedByCount "2" @default.
- W2140321502 countsByYear W21403215022015 @default.
- W2140321502 crossrefType "journal-article" @default.
- W2140321502 hasAuthorship W2140321502A5019792391 @default.
- W2140321502 hasAuthorship W2140321502A5050230312 @default.
- W2140321502 hasAuthorship W2140321502A5055033211 @default.
- W2140321502 hasAuthorship W2140321502A5084023342 @default.
- W2140321502 hasBestOaLocation W21403215021 @default.
- W2140321502 hasConcept C108586683 @default.
- W2140321502 hasConcept C11268172 @default.
- W2140321502 hasConcept C12554922 @default.
- W2140321502 hasConcept C150903083 @default.
- W2140321502 hasConcept C178790620 @default.
- W2140321502 hasConcept C184651966 @default.
- W2140321502 hasConcept C185592680 @default.
- W2140321502 hasConcept C188027245 @default.
- W2140321502 hasConcept C202751555 @default.
- W2140321502 hasConcept C203014093 @default.
- W2140321502 hasConcept C207001950 @default.
- W2140321502 hasConcept C2776914184 @default.
- W2140321502 hasConcept C2778823387 @default.
- W2140321502 hasConcept C2779244956 @default.
- W2140321502 hasConcept C2779820397 @default.
- W2140321502 hasConcept C4863142 @default.
- W2140321502 hasConcept C49039625 @default.
- W2140321502 hasConcept C55493867 @default.
- W2140321502 hasConcept C86803240 @default.
- W2140321502 hasConceptScore W2140321502C108586683 @default.
- W2140321502 hasConceptScore W2140321502C11268172 @default.
- W2140321502 hasConceptScore W2140321502C12554922 @default.
- W2140321502 hasConceptScore W2140321502C150903083 @default.
- W2140321502 hasConceptScore W2140321502C178790620 @default.
- W2140321502 hasConceptScore W2140321502C184651966 @default.
- W2140321502 hasConceptScore W2140321502C185592680 @default.
- W2140321502 hasConceptScore W2140321502C188027245 @default.