FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140328592> ?p ?o ?g. }

• W2140328592 endingPage "14" @default.
• W2140328592 startingPage "5" @default.
• W2140328592 abstract "Sodium-potassium ATPase (Na/K ATPase) is a major target of mineralocorticoids. Both aldosterone and glucocorticoids activate the human Na/K ATPase alpha1 and beta1 genes transcriptionally. The mineralocorticoid receptor (MR) and the glucocorticoid receptor (GR) have been shown to bind the glucocorticoid response element (GRE); however, a specific element responsible for the activation of the MR is not known. Sequence analysis of the putative regulatory region of the Na/K ATPase alpha1 gene revealed the presence of a hormone response element that allows the MR to interact with it, at least as well as if not better than the GR. This response element is designated MRE/GRE. In this investigation, we demonstrated the MR and GR induced gene expression in COS-1 cells by cotransfecting with respective expression plasmids (RshMR and RshGR) along with a luciferase reporter. The synthetic MRE/GRE linked to a neutral promoter was activated by MR (6-fold); however, the GR induced a lower level of expression (3.8-fold), suggesting that the element may be preferably MR responsive. Mutations in the synthetic MRE/GRE could not induce the expression with MR, whereas GR had a small effect. Electrophoretic mobility shift analyses demonstrated a direct interaction of MR and GR with the MRE/GRE that was supershifted by an antiMR antibody and the complex was partially cleared by an antiGR antibody, respectively, whereas nonimmune serum had no effect. Footprinting analyses of the promoter region showed that a portion of the DNA containing this element is protected by recombinant MR and GR. Thus these data confirm that this MRE/GRE interacts with both MR and GR but interaction with receptors may be more MR-responsive than response elements previously described." @default.
• W2140328592 created "2016-06-24" @default.
• W2140328592 creator A5002567610 @default.
• W2140328592 creator A5062814155 @default.
• W2140328592 creator A5090210226 @default.
• W2140328592 date "1999-12-01" @default.
• W2140328592 modified "2023-09-23" @default.
• W2140328592 title "Identification of a Mineralocorticoid/Glucocorticoid Response Element in the Human Na/K ATPase α1 Gene Promoter" @default.
• W2140328592 cites W1498270936 @default.
• W2140328592 cites W1501286679 @default.
• W2140328592 cites W1507132539 @default.
• W2140328592 cites W1511788007 @default.
• W2140328592 cites W1516168649 @default.
• W2140328592 cites W1520012696 @default.
• W2140328592 cites W1864394606 @default.
• W2140328592 cites W1964628557 @default.
• W2140328592 cites W1968905365 @default.
• W2140328592 cites W1974950683 @default.
• W2140328592 cites W1981812310 @default.
• W2140328592 cites W1987183940 @default.
• W2140328592 cites W1990571275 @default.
• W2140328592 cites W1992098567 @default.
• W2140328592 cites W1993137058 @default.
• W2140328592 cites W1994673724 @default.
• W2140328592 cites W1996475780 @default.
• W2140328592 cites W2005914718 @default.
• W2140328592 cites W2015497140 @default.
• W2140328592 cites W2022404085 @default.
• W2140328592 cites W2023070205 @default.
• W2140328592 cites W2026351712 @default.
• W2140328592 cites W2031181863 @default.
• W2140328592 cites W2031667205 @default.
• W2140328592 cites W2052509497 @default.
• W2140328592 cites W2058855160 @default.
• W2140328592 cites W2068113812 @default.
• W2140328592 cites W2082181748 @default.
• W2140328592 cites W2095465583 @default.
• W2140328592 cites W2116865760 @default.
• W2140328592 cites W2119725374 @default.
• W2140328592 cites W2128840922 @default.
• W2140328592 cites W2130963272 @default.
• W2140328592 cites W2142442530 @default.
• W2140328592 cites W2605614532 @default.
• W2140328592 doi "https://doi.org/10.1006/bbrc.1999.1765" @default.
• W2140328592 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10581156" @default.
• W2140328592 hasPublicationYear "1999" @default.
• W2140328592 type Work @default.
• W2140328592 sameAs 2140328592 @default.
• W2140328592 citedByCount "53" @default.
• W2140328592 countsByYear W21403285922012 @default.
• W2140328592 countsByYear W21403285922013 @default.
• W2140328592 countsByYear W21403285922014 @default.
• W2140328592 countsByYear W21403285922015 @default.
• W2140328592 countsByYear W21403285922017 @default.
• W2140328592 countsByYear W21403285922018 @default.
• W2140328592 countsByYear W21403285922019 @default.
• W2140328592 countsByYear W21403285922020 @default.
• W2140328592 countsByYear W21403285922021 @default.
• W2140328592 countsByYear W21403285922022 @default.
• W2140328592 crossrefType "journal-article" @default.
• W2140328592 hasAuthorship W2140328592A5002567610 @default.
• W2140328592 hasAuthorship W2140328592A5062814155 @default.
• W2140328592 hasAuthorship W2140328592A5090210226 @default.
• W2140328592 hasConcept C101762097 @default.
• W2140328592 hasConcept C104317684 @default.
• W2140328592 hasConcept C121608353 @default.
• W2140328592 hasConcept C132376346 @default.
• W2140328592 hasConcept C134018914 @default.
• W2140328592 hasConcept C150194340 @default.
• W2140328592 hasConcept C153911025 @default.
• W2140328592 hasConcept C161733203 @default.
• W2140328592 hasConcept C185592680 @default.
• W2140328592 hasConcept C189135053 @default.
• W2140328592 hasConcept C2776069600 @default.
• W2140328592 hasConcept C2778525890 @default.
• W2140328592 hasConcept C2780841215 @default.
• W2140328592 hasConcept C51445715 @default.
• W2140328592 hasConcept C530470458 @default.
• W2140328592 hasConcept C54355233 @default.
• W2140328592 hasConcept C55493867 @default.
• W2140328592 hasConcept C59493245 @default.
• W2140328592 hasConcept C84606932 @default.
• W2140328592 hasConcept C86803240 @default.
• W2140328592 hasConceptScore W2140328592C101762097 @default.
• W2140328592 hasConceptScore W2140328592C104317684 @default.
• W2140328592 hasConceptScore W2140328592C121608353 @default.
• W2140328592 hasConceptScore W2140328592C132376346 @default.
• W2140328592 hasConceptScore W2140328592C134018914 @default.
• W2140328592 hasConceptScore W2140328592C150194340 @default.
• W2140328592 hasConceptScore W2140328592C153911025 @default.
• W2140328592 hasConceptScore W2140328592C161733203 @default.
• W2140328592 hasConceptScore W2140328592C185592680 @default.
• W2140328592 hasConceptScore W2140328592C189135053 @default.
• W2140328592 hasConceptScore W2140328592C2776069600 @default.
• W2140328592 hasConceptScore W2140328592C2778525890 @default.
• W2140328592 hasConceptScore W2140328592C2780841215 @default.
• W2140328592 hasConceptScore W2140328592C51445715 @default.
• W2140328592 hasConceptScore W2140328592C530470458 @default.

• next