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- W2140332605 abstract "Human skin blood flow is controlled via dual innervation from the sympathetic nervous system. Reflex cutaneous vasoconstriction and vasodilation are both impaired with primary aging, rendering the aged more vulnerable to hypothermia and cardiovascular complications from heat-related illness. Age-related alterations in the thermoregulatory control of skin blood flow occur at multiple points along the efferent arm of the reflex, including 1) diminished sympathetic outflow, 2) altered presynaptic neurotransmitter synthesis, 3) reduced vascular responsiveness, and 4) impairments in downstream (endothelial and vascular smooth muscle) second-messenger signaling. This mechanistic review highlights some of the recent findings in the area of aging and the thermoregulatory control of skin blood flow." @default.
- W2140332605 created "2016-06-24" @default.
- W2140332605 creator A5021357378 @default.
- W2140332605 creator A5024732141 @default.
- W2140332605 date "2010-11-01" @default.
- W2140332605 modified "2023-10-18" @default.
- W2140332605 title "Peripheral mechanisms of thermoregulatory control of skin blood flow in aged humans" @default.
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- W2140332605 doi "https://doi.org/10.1152/japplphysiol.00338.2010" @default.
- W2140332605 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3774123" @default.
- W2140332605 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20413421" @default.
- W2140332605 hasPublicationYear "2010" @default.
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