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- W2140339203 abstract "The data on the examination of early vascular alterations in carriers of molecular defects of the LDL-R in comparison to non-carriers with severe hypercholesterolemia are controversial. Aim: To examine the difference between patients with severe hypercholesterolemia, who are carriers and non-carriers of LDL-R defective gene, with respect to their structural (intima-media thickness of carotid artery) characteristics of arterial wall. A total of 60 hypercholesterolemic patients were enrolled. Biochemistry parameters were examined by routine methods. Determination of intima-media thickness of common carotid artery was performed with Hewlett Packard Sonos 5 500, using automated computer software MedicaSoft. IMT.lab. Results: There was no significant difference between the groups with respect to total cholesterol, LDL, HDL, triglycerides. We were founded a significantly higher carotid IMT in the carriers versus non-carriers. This significant difference was confirmed after adjustment for age and gender. Conclusion: Our data demonstrate that carriers of the LDL-R defective gene have a higher carotid IMT than non-carriers, whereas no difference between the groups was found with respect to the level of lipid parameters." @default.
- W2140339203 created "2016-06-24" @default.
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- W2140339203 date "2011-04-19" @default.
- W2140339203 modified "2023-09-24" @default.
- W2140339203 title "INTIMA-MEDIA THICKNESS OF THE COMMON CAROTID ARTERY AND LDL-R DEFECT IN ASYMPTOMATIC SEVERE HYPERCHOLESTEROLEMIA" @default.
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- W2140339203 doi "https://doi.org/10.5272/jimab.1632010_78" @default.
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