Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140342004> ?p ?o ?g. }
- W2140342004 endingPage "472" @default.
- W2140342004 startingPage "459" @default.
- W2140342004 abstract "Background: Disulfiram has demonstrated efficacy in six randomized clinical trials for the treatment of cocaine dependence, but is rarely used in clinical settings because of safety concerns. Objective: What are the common and serious side effects of disulfiram in cocaine-dependent individuals with and without alcohol dependence in randomized clinical trials? Methods: We located Phase I and II randomized trials that discussed the safety of disulfiram. Results/conclusions: In randomized clinical trials that eliminated subjects with serious cardiovascular, hepatic, and psychiatric disorders, the most frequent side effects of disulfiram over placebo or index groups include headaches, fatigue, sleepiness, and anxiety. Disulfiram in a dose of ≤ 250 mg/day led to only mild interactions with alcohol. When patients are screened for medical and psychiatric stability, and are evaluated for drug interactions, disulfiram has an acceptable side-effect profile for the treatment of cocaine dependence with or without alcohol dependence." @default.
- W2140342004 created "2016-06-24" @default.
- W2140342004 creator A5002991006 @default.
- W2140342004 creator A5076836999 @default.
- W2140342004 creator A5082066139 @default.
- W2140342004 date "2008-07-01" @default.
- W2140342004 modified "2023-10-17" @default.
- W2140342004 title "The safety of disulfiram for the treatment of alcohol and cocaine dependence in randomized clinical trials: guidance for clinical practice" @default.
- W2140342004 cites W1550689978 @default.
- W2140342004 cites W179028651 @default.
- W2140342004 cites W1898440000 @default.
- W2140342004 cites W1963653828 @default.
- W2140342004 cites W1967589215 @default.
- W2140342004 cites W1972579292 @default.
- W2140342004 cites W1977850625 @default.
- W2140342004 cites W1982315272 @default.
- W2140342004 cites W1982557686 @default.
- W2140342004 cites W1983096520 @default.
- W2140342004 cites W1989338683 @default.
- W2140342004 cites W1990492557 @default.
- W2140342004 cites W1993669700 @default.
- W2140342004 cites W1994701170 @default.
- W2140342004 cites W1998705458 @default.
- W2140342004 cites W2001268900 @default.
- W2140342004 cites W2019709536 @default.
- W2140342004 cites W2020897794 @default.
- W2140342004 cites W2025369226 @default.
- W2140342004 cites W2025585415 @default.
- W2140342004 cites W2042321159 @default.
- W2140342004 cites W2042895270 @default.
- W2140342004 cites W2055534658 @default.
- W2140342004 cites W2064218769 @default.
- W2140342004 cites W2067140702 @default.
- W2140342004 cites W2067778248 @default.
- W2140342004 cites W2067795033 @default.
- W2140342004 cites W2071969529 @default.
- W2140342004 cites W2082206299 @default.
- W2140342004 cites W2084541153 @default.
- W2140342004 cites W2091754143 @default.
- W2140342004 cites W2101752617 @default.
- W2140342004 cites W2103224516 @default.
- W2140342004 cites W2112861803 @default.
- W2140342004 cites W2141218546 @default.
- W2140342004 cites W2148110404 @default.
- W2140342004 cites W2149188765 @default.
- W2140342004 cites W2155020495 @default.
- W2140342004 cites W2156122963 @default.
- W2140342004 cites W2443658519 @default.
- W2140342004 cites W2619521118 @default.
- W2140342004 cites W4236852867 @default.
- W2140342004 doi "https://doi.org/10.1517/14740338.7.4.459" @default.
- W2140342004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18613809" @default.
- W2140342004 hasPublicationYear "2008" @default.
- W2140342004 type Work @default.
- W2140342004 sameAs 2140342004 @default.
- W2140342004 citedByCount "46" @default.
- W2140342004 countsByYear W21403420042012 @default.
- W2140342004 countsByYear W21403420042013 @default.
- W2140342004 countsByYear W21403420042014 @default.
- W2140342004 countsByYear W21403420042015 @default.
- W2140342004 countsByYear W21403420042016 @default.
- W2140342004 countsByYear W21403420042017 @default.
- W2140342004 countsByYear W21403420042018 @default.
- W2140342004 countsByYear W21403420042019 @default.
- W2140342004 countsByYear W21403420042020 @default.
- W2140342004 countsByYear W21403420042021 @default.
- W2140342004 countsByYear W21403420042022 @default.
- W2140342004 countsByYear W21403420042023 @default.
- W2140342004 crossrefType "journal-article" @default.
- W2140342004 hasAuthorship W2140342004A5002991006 @default.
- W2140342004 hasAuthorship W2140342004A5076836999 @default.
- W2140342004 hasAuthorship W2140342004A5082066139 @default.
- W2140342004 hasConcept C118552586 @default.
- W2140342004 hasConcept C126322002 @default.
- W2140342004 hasConcept C142724271 @default.
- W2140342004 hasConcept C168563851 @default.
- W2140342004 hasConcept C185592680 @default.
- W2140342004 hasConcept C197934379 @default.
- W2140342004 hasConcept C199360897 @default.
- W2140342004 hasConcept C204787440 @default.
- W2140342004 hasConcept C27081682 @default.
- W2140342004 hasConcept C2778523461 @default.
- W2140342004 hasConcept C2779436514 @default.
- W2140342004 hasConcept C2779796075 @default.
- W2140342004 hasConcept C2781066024 @default.
- W2140342004 hasConcept C3454156 @default.
- W2140342004 hasConcept C41008148 @default.
- W2140342004 hasConcept C48856860 @default.
- W2140342004 hasConcept C535046627 @default.
- W2140342004 hasConcept C55493867 @default.
- W2140342004 hasConcept C71924100 @default.
- W2140342004 hasConcept C98274493 @default.
- W2140342004 hasConceptScore W2140342004C118552586 @default.
- W2140342004 hasConceptScore W2140342004C126322002 @default.
- W2140342004 hasConceptScore W2140342004C142724271 @default.
- W2140342004 hasConceptScore W2140342004C168563851 @default.
- W2140342004 hasConceptScore W2140342004C185592680 @default.
- W2140342004 hasConceptScore W2140342004C197934379 @default.