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• W2140350595 abstract "Although suppression of apoptosis contributes to immune-reconstitution during potent antiretroviral therapy, its relationship with the majors indicators of response to therapy, that is, changes in CD4(+) cell counts and in viral loads (VL), is still debated. We extended our previous study by collecting data on the relationships among apoptosis and immunological and virological parameters during a long-term follow-up of HIV patients with an overall positive response to potent antiretroviral therapy. We report results from 15 patients who completed two years of therapy. In a smaller group of patients, we focused our attention on investigating the specific contribution of the CD8(+) subset in the overall changes in lymphocyte apoptosis, which occur concomitantly with the response to the therapy. Our data, while again confirming that inhibition of PBMC apoptosis is a phenomenon strictly related to a positive response to potent antiretroviral therapy, suggest that CD4(+) cell rescue is not directly dependent on inhibition of CD4(+) cell apoptosis but rather on that of the CD8(+) subset." @default.
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• W2140350595 date "2003-12-01" @default.
• W2140350595 modified "2023-10-13" @default.
• W2140350595 title "CD4+Lymphocyte Increases in HIV Patients during Potent Antiretroviral Therapy Are Dependent on Inhibition of CD8+Cell Apoptosis" @default.
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• W2140350595 doi "https://doi.org/10.1196/annals.1299.104" @default.
• W2140350595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15033791" @default.
• W2140350595 hasPublicationYear "2003" @default.
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