Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140368445> ?p ?o ?g. }
- W2140368445 endingPage "790" @default.
- W2140368445 startingPage "783" @default.
- W2140368445 abstract "Nasal polyposis (NP) is a chronic inflammatory disease of the sinuses. Its pathogenesis is unknown. DNA microarray analysis allows simultaneous measurement of expression of thousands of genes in the same tissue sample and might help to identify gene alterations in various disorders.We sought to screen for disease-related genes in NP by using DNA microarrays and to validate the altered expression of selected genes at the mRNA and protein level.Expression microarrays containing approximately 10,500 genes were used to compare individual gene profiles of NP samples (n=10) and normal mucosal samples obtained from sphenoid sinuses in patients undergoing pituitary surgery (n=4). Four of the 5 most upregulated, and the single most downregulated, genes were retested by means of quantitative RT-PCR and immunohistochemistry in a different set of NP and normal mucosal samples obtained from the ethmoid and sphenoid sinuses.Compared with normal sinus tissue, 192 genes were upregulated at least 2-fold, and 156 genes were downregulated by at least 50% in NP samples (approximately 3% of genes evaluated). Four of the top 5 overexpressed genes (statherin, 48.0-fold; prolactin-induced protein [PIP] , 24.9-fold; lactoferrin, 26.6-fold; and deleted in malignant brain tumor 1 [DMBT1] , 30.3-fold) and the most underexpressed gene (Clara cell 10-kd protein [CC10] , -20.1-fold) were selected and retested by means of quantitative RT-PCR and immunohistochemical staining. Quantitative RT-PCR and immunohistochemical staining confirmed the differential expression of all except statherin in NP tissue.DNA microarrays can provide new insight into the possible pathophysiologic processes involved in NP." @default.
- W2140368445 created "2016-06-24" @default.
- W2140368445 creator A5004888276 @default.
- W2140368445 creator A5007350640 @default.
- W2140368445 creator A5007406317 @default.
- W2140368445 creator A5032657640 @default.
- W2140368445 creator A5034750122 @default.
- W2140368445 creator A5061672936 @default.
- W2140368445 creator A5066039452 @default.
- W2140368445 date "2004-10-01" @default.
- W2140368445 modified "2023-10-17" @default.
- W2140368445 title "Gene expression profiles in human nasal polyp tissues studied by means of DNA microarray" @default.
- W2140368445 cites W1569624226 @default.
- W2140368445 cites W1575453988 @default.
- W2140368445 cites W1671505928 @default.
- W2140368445 cites W1805024973 @default.
- W2140368445 cites W1852199403 @default.
- W2140368445 cites W1917954905 @default.
- W2140368445 cites W1964440384 @default.
- W2140368445 cites W1965024312 @default.
- W2140368445 cites W1977813572 @default.
- W2140368445 cites W1984259223 @default.
- W2140368445 cites W2000119465 @default.
- W2140368445 cites W2007487522 @default.
- W2140368445 cites W2010147738 @default.
- W2140368445 cites W2020731315 @default.
- W2140368445 cites W2033696559 @default.
- W2140368445 cites W2046404403 @default.
- W2140368445 cites W2046644412 @default.
- W2140368445 cites W2054406522 @default.
- W2140368445 cites W2056975585 @default.
- W2140368445 cites W2073151710 @default.
- W2140368445 cites W2091148915 @default.
- W2140368445 cites W2095199396 @default.
- W2140368445 cites W2095385896 @default.
- W2140368445 cites W2098165008 @default.
- W2140368445 cites W2102206573 @default.
- W2140368445 cites W2107277218 @default.
- W2140368445 cites W2110312420 @default.
- W2140368445 cites W2117095110 @default.
- W2140368445 cites W2124994779 @default.
- W2140368445 cites W2125566475 @default.
- W2140368445 cites W2127386626 @default.
- W2140368445 cites W2128498632 @default.
- W2140368445 cites W2131696337 @default.
- W2140368445 cites W2147049357 @default.
- W2140368445 cites W2165366028 @default.
- W2140368445 cites W2299822724 @default.
- W2140368445 cites W2313199988 @default.
- W2140368445 cites W2398137194 @default.
- W2140368445 cites W2416993367 @default.
- W2140368445 cites W34163939 @default.
- W2140368445 cites W435481956 @default.
- W2140368445 cites W607360846 @default.
- W2140368445 cites W91095816 @default.
- W2140368445 doi "https://doi.org/10.1016/j.jaci.2004.04.052" @default.
- W2140368445 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15480316" @default.
- W2140368445 hasPublicationYear "2004" @default.
- W2140368445 type Work @default.
- W2140368445 sameAs 2140368445 @default.
- W2140368445 citedByCount "105" @default.
- W2140368445 countsByYear W21403684452012 @default.
- W2140368445 countsByYear W21403684452013 @default.
- W2140368445 countsByYear W21403684452014 @default.
- W2140368445 countsByYear W21403684452015 @default.
- W2140368445 countsByYear W21403684452016 @default.
- W2140368445 countsByYear W21403684452017 @default.
- W2140368445 countsByYear W21403684452018 @default.
- W2140368445 countsByYear W21403684452019 @default.
- W2140368445 countsByYear W21403684452020 @default.
- W2140368445 countsByYear W21403684452021 @default.
- W2140368445 countsByYear W21403684452022 @default.
- W2140368445 countsByYear W21403684452023 @default.
- W2140368445 crossrefType "journal-article" @default.
- W2140368445 hasAuthorship W2140368445A5004888276 @default.
- W2140368445 hasAuthorship W2140368445A5007350640 @default.
- W2140368445 hasAuthorship W2140368445A5007406317 @default.
- W2140368445 hasAuthorship W2140368445A5032657640 @default.
- W2140368445 hasAuthorship W2140368445A5034750122 @default.
- W2140368445 hasAuthorship W2140368445A5061672936 @default.
- W2140368445 hasAuthorship W2140368445A5066039452 @default.
- W2140368445 hasConcept C104317684 @default.
- W2140368445 hasConcept C142724271 @default.
- W2140368445 hasConcept C150194340 @default.
- W2140368445 hasConcept C153911025 @default.
- W2140368445 hasConcept C18431079 @default.
- W2140368445 hasConcept C186836561 @default.
- W2140368445 hasConcept C203014093 @default.
- W2140368445 hasConcept C204232928 @default.
- W2140368445 hasConcept C48023723 @default.
- W2140368445 hasConcept C54355233 @default.
- W2140368445 hasConcept C71924100 @default.
- W2140368445 hasConcept C8415881 @default.
- W2140368445 hasConcept C86803240 @default.
- W2140368445 hasConcept C95371953 @default.
- W2140368445 hasConceptScore W2140368445C104317684 @default.
- W2140368445 hasConceptScore W2140368445C142724271 @default.
- W2140368445 hasConceptScore W2140368445C150194340 @default.