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• W2140371247 abstract "Diverse roles in DNA metabolism have been envisaged for budding yeast and mammalian Rif1. In particular, yeast Rif1 is involved in telomere homeostasis, while its mammalian counterpart participates in the cellular response to DNA double-strand breaks (DSBs). Here, we show that Saccharomyces cerevisiae Rif1 supports cell survival to DNA lesions in the absence of MRX or Sae2. Furthermore, it contributes to the nucleolytic processing (resection) of DSBs. This Rif1-dependent control of DSB resection becomes important for DSB repair by homologous recombination when resection activities are suboptimal." @default.
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• W2140371247 date "2014-04-01" @default.
• W2140371247 modified "2023-10-11" @default.
• W2140371247 title "Saccharomyces cerevisiae Rif1 cooperates with MRX-Sae2 in promoting DNA-end resection" @default.
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• W2140371247 doi "https://doi.org/10.1002/embr.201338338" @default.
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