FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140374671> ?p ?o ?g. }

• W2140374671 endingPage "983" @default.
• W2140374671 startingPage "976" @default.
• W2140374671 abstract "BACKGROUND Limited information exists regarding the use of posaconazole for treating systemic fungal infections in children, adolescents, and young adults with cancer. At St. Jude Children's Research Hospital, the recommended posaconazole dose in patients weighing less than 34 kg is 18–24 mg/kg daily, given in 4 divided doses. For patients aged 13 years or older or those weighing 34 kg or more, the recommended dose is 800 mg daily, given orally in 4 divided doses. OBJECTIVE To determine whether the current posaconazole dosing guidelines achieve target posaconazole plasma concentrations of 0.7 μg/mL or greater. METHODS This retrospective clinical study examined data from patients who received treatment-dose posaconazole and had at least 1 posaconazole plasma concentration measurement. RESULTS Data from 33 patients who received posaconazole for the treatment of fungal infections were analyzed. The median age of patients was 11.5 years (range 0.5–23.2). Twenty-one of 33 patients (63.6%) had posaconazole concentrations of 0.7 μg/mL or greater (median 1.4; range 0.7–2.98) at the first measurement. The median posaconazole dosage referenced to total body weight in these patients was 20 mg/kg/day. Patients with concentrations less than 0.7 μg/mL (median 0.4; range 0.025–0.69) received lower posaconazole dosages when referenced to body weight (median 12.9 mg/kg/day; p = 0.02). Of the 12 patients with concentrations less than 0.7 μg/mL, 7 (58.3%) were aged 13 years or older. CONCLUSIONS The current dosing approach for posaconazole yielded therapeutic plasma concentrations more frequently in patients younger than 13 years than in those 13 years or older. This difference may be related to the practice of capping adolescent and young adult doses at the suggested maximum adult daily dose. Therefore, we recommend weight-based dosing in all pediatric, adolescent, and young adult patients with cancer, with routine therapeutic drug monitoring to ensure adequate concentrations." @default.
• W2140374671 created "2016-06-24" @default.
• W2140374671 creator A5001311437 @default.
• W2140374671 creator A5048392799 @default.
• W2140374671 creator A5048948701 @default.
• W2140374671 creator A5053032153 @default.
• W2140374671 creator A5054376988 @default.
• W2140374671 creator A5071557103 @default.
• W2140374671 creator A5073741381 @default.
• W2140374671 creator A5079793536 @default.
• W2140374671 creator A5085620590 @default.
• W2140374671 date "2013-06-04" @default.
• W2140374671 modified "2023-09-26" @default.
• W2140374671 title "Posaconazole Therapeutic Drug Monitoring in Pediatric Patients and Young Adults with Cancer" @default.
• W2140374671 cites W1973282809 @default.
• W2140374671 cites W1990371288 @default.
• W2140374671 cites W2014557179 @default.
• W2140374671 cites W2018917176 @default.
• W2140374671 cites W2051723321 @default.
• W2140374671 cites W2051949757 @default.
• W2140374671 cites W2058577472 @default.
• W2140374671 cites W2083287237 @default.
• W2140374671 cites W2102649824 @default.
• W2140374671 cites W2106243271 @default.
• W2140374671 cites W2108597723 @default.
• W2140374671 cites W2111849396 @default.
• W2140374671 cites W2117813373 @default.
• W2140374671 cites W2134774528 @default.
• W2140374671 cites W2142996250 @default.
• W2140374671 cites W2154955932 @default.
• W2140374671 cites W2158597663 @default.
• W2140374671 cites W2170116263 @default.
• W2140374671 cites W2170326270 @default.
• W2140374671 cites W2322896657 @default.
• W2140374671 doi "https://doi.org/10.1345/aph.1r775" @default.
• W2140374671 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4384822" @default.
• W2140374671 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23737511" @default.
• W2140374671 hasPublicationYear "2013" @default.
• W2140374671 type Work @default.
• W2140374671 sameAs 2140374671 @default.
• W2140374671 citedByCount "43" @default.
• W2140374671 countsByYear W21403746712014 @default.
• W2140374671 countsByYear W21403746712015 @default.
• W2140374671 countsByYear W21403746712016 @default.
• W2140374671 countsByYear W21403746712017 @default.
• W2140374671 countsByYear W21403746712018 @default.
• W2140374671 countsByYear W21403746712019 @default.
• W2140374671 countsByYear W21403746712020 @default.
• W2140374671 countsByYear W21403746712021 @default.
• W2140374671 countsByYear W21403746712022 @default.
• W2140374671 countsByYear W21403746712023 @default.
• W2140374671 crossrefType "journal-article" @default.
• W2140374671 hasAuthorship W2140374671A5001311437 @default.
• W2140374671 hasAuthorship W2140374671A5048392799 @default.
• W2140374671 hasAuthorship W2140374671A5048948701 @default.
• W2140374671 hasAuthorship W2140374671A5053032153 @default.
• W2140374671 hasAuthorship W2140374671A5054376988 @default.
• W2140374671 hasAuthorship W2140374671A5071557103 @default.
• W2140374671 hasAuthorship W2140374671A5073741381 @default.
• W2140374671 hasAuthorship W2140374671A5079793536 @default.
• W2140374671 hasAuthorship W2140374671A5085620590 @default.
• W2140374671 hasBestOaLocation W21403746712 @default.
• W2140374671 hasConcept C112705442 @default.
• W2140374671 hasConcept C121608353 @default.
• W2140374671 hasConcept C126322002 @default.
• W2140374671 hasConcept C141071460 @default.
• W2140374671 hasConcept C16005928 @default.
• W2140374671 hasConcept C162156334 @default.
• W2140374671 hasConcept C167135981 @default.
• W2140374671 hasConcept C2777288759 @default.
• W2140374671 hasConcept C2778566413 @default.
• W2140374671 hasConcept C2779548794 @default.
• W2140374671 hasConcept C2780272996 @default.
• W2140374671 hasConcept C2780690907 @default.
• W2140374671 hasConcept C2993561819 @default.
• W2140374671 hasConcept C71924100 @default.
• W2140374671 hasConcept C90924648 @default.
• W2140374671 hasConceptScore W2140374671C112705442 @default.
• W2140374671 hasConceptScore W2140374671C121608353 @default.
• W2140374671 hasConceptScore W2140374671C126322002 @default.
• W2140374671 hasConceptScore W2140374671C141071460 @default.
• W2140374671 hasConceptScore W2140374671C16005928 @default.
• W2140374671 hasConceptScore W2140374671C162156334 @default.
• W2140374671 hasConceptScore W2140374671C167135981 @default.
• W2140374671 hasConceptScore W2140374671C2777288759 @default.
• W2140374671 hasConceptScore W2140374671C2778566413 @default.
• W2140374671 hasConceptScore W2140374671C2779548794 @default.
• W2140374671 hasConceptScore W2140374671C2780272996 @default.
• W2140374671 hasConceptScore W2140374671C2780690907 @default.
• W2140374671 hasConceptScore W2140374671C2993561819 @default.
• W2140374671 hasConceptScore W2140374671C71924100 @default.
• W2140374671 hasConceptScore W2140374671C90924648 @default.
• W2140374671 hasIssue "7-8" @default.
• W2140374671 hasLocation W21403746711 @default.
• W2140374671 hasLocation W21403746712 @default.
• W2140374671 hasLocation W21403746713 @default.
• W2140374671 hasOpenAccess W2140374671 @default.
• W2140374671 hasPrimaryLocation W21403746711 @default.

• next