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• W2140396281 endingPage "e0138129" @default.
• W2140396281 startingPage "e0138129" @default.
• W2140396281 abstract "Food intake is an essential animal activity, regulated by neural circuits that motivate food localization, evaluate nutritional content and acceptance or rejection responses through the gustatory system, and regulate neuroendocrine feedback loops that maintain energy homeostasis. Excess food consumption in people is associated with obesity and metabolic and cardiovascular disorders. However, little is known about the genetic basis of natural variation in food consumption. To gain insights in evolutionarily conserved genetic principles that regulate food intake, we took advantage of a model system, Drosophila melanogaster, in which food intake, environmental conditions and genetic background can be controlled precisely. We quantified variation in food intake among 182 inbred, sequenced lines of the Drosophila melanogaster Genetic Reference Panel (DGRP). We found significant genetic variation in the mean and within-line environmental variance of food consumption and observed sexual dimorphism and genetic variation in sexual dimorphism for both food intake traits (mean and variance). We performed genome wide association (GWA) analyses for mean food intake and environmental variance of food intake (using the coefficient of environmental variation, CVE, as the metric for environmental variance) and identified molecular polymorphisms associated with both traits. Validation experiments using RNAi-knockdown confirmed 24 of 31 (77%) candidate genes affecting food intake and/or variance of food intake, and a test cross between selected DGRP lines confirmed a SNP affecting mean food intake identified in the GWA analysis. The majority of the validated candidate genes were novel with respect to feeding behavior, and many had mammalian orthologs implicated in metabolic diseases." @default.
• W2140396281 created "2016-06-24" @default.
• W2140396281 creator A5017483128 @default.
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• W2140396281 creator A5053024731 @default.
• W2140396281 creator A5053386905 @default.
• W2140396281 creator A5072186146 @default.
• W2140396281 date "2015-09-16" @default.
• W2140396281 modified "2023-10-16" @default.
• W2140396281 title "Quantitative Genetics of Food Intake in Drosophila melanogaster" @default.
• W2140396281 cites W1572656115 @default.
• W2140396281 cites W1689177678 @default.
• W2140396281 cites W1780767919 @default.
• W2140396281 cites W1876068674 @default.
• W2140396281 cites W1876661592 @default.
• W2140396281 cites W1935370848 @default.
• W2140396281 cites W1966824338 @default.
• W2140396281 cites W1967495624 @default.
• W2140396281 cites W1968010393 @default.
• W2140396281 cites W1968273072 @default.
• W2140396281 cites W1968440930 @default.
• W2140396281 cites W1968931484 @default.
• W2140396281 cites W1969453048 @default.
• W2140396281 cites W1972552869 @default.
• W2140396281 cites W1975616811 @default.
• W2140396281 cites W1977409932 @default.
• W2140396281 cites W1980800386 @default.
• W2140396281 cites W1980991473 @default.
• W2140396281 cites W1981193744 @default.
• W2140396281 cites W1981922832 @default.
• W2140396281 cites W1983208716 @default.
• W2140396281 cites W1984088514 @default.
• W2140396281 cites W1984269054 @default.
• W2140396281 cites W1984976649 @default.
• W2140396281 cites W1986562178 @default.
• W2140396281 cites W1986574990 @default.
• W2140396281 cites W1987322175 @default.
• W2140396281 cites W1988068820 @default.
• W2140396281 cites W1988694228 @default.
• W2140396281 cites W1989380425 @default.
• W2140396281 cites W1990979687 @default.
• W2140396281 cites W1994236426 @default.
• W2140396281 cites W1996016786 @default.
• W2140396281 cites W1996470896 @default.
• W2140396281 cites W1996638581 @default.
• W2140396281 cites W1997192841 @default.
• W2140396281 cites W1999939320 @default.
• W2140396281 cites W2000071989 @default.
• W2140396281 cites W2002055235 @default.
• W2140396281 cites W2002445028 @default.
• W2140396281 cites W2002612687 @default.
• W2140396281 cites W2003868871 @default.
• W2140396281 cites W2006729121 @default.
• W2140396281 cites W2007301606 @default.
• W2140396281 cites W2011518200 @default.
• W2140396281 cites W2011568655 @default.
• W2140396281 cites W2013689843 @default.
• W2140396281 cites W2014079380 @default.
• W2140396281 cites W2014771784 @default.
• W2140396281 cites W2016557911 @default.
• W2140396281 cites W2017201559 @default.
• W2140396281 cites W2017252713 @default.
• W2140396281 cites W2018949182 @default.
• W2140396281 cites W2019575716 @default.
• W2140396281 cites W2026243569 @default.
• W2140396281 cites W2027837618 @default.
• W2140396281 cites W2028670385 @default.
• W2140396281 cites W2029741513 @default.
• W2140396281 cites W2030439009 @default.
• W2140396281 cites W2033379465 @default.
• W2140396281 cites W2033705933 @default.
• W2140396281 cites W2033745161 @default.
• W2140396281 cites W2034168204 @default.
• W2140396281 cites W2034840220 @default.
• W2140396281 cites W2038122931 @default.
• W2140396281 cites W2039432238 @default.
• W2140396281 cites W2040705264 @default.
• W2140396281 cites W2040797521 @default.
• W2140396281 cites W2042814330 @default.
• W2140396281 cites W2043760958 @default.
• W2140396281 cites W2044360145 @default.
• W2140396281 cites W2044424966 @default.
• W2140396281 cites W2045759524 @default.
• W2140396281 cites W2046037006 @default.
• W2140396281 cites W2048595446 @default.
• W2140396281 cites W2048712716 @default.
• W2140396281 cites W2050915090 @default.
• W2140396281 cites W2054512979 @default.
• W2140396281 cites W2055069916 @default.
• W2140396281 cites W2055646225 @default.
• W2140396281 cites W2057686341 @default.
• W2140396281 cites W2059846376 @default.
• W2140396281 cites W2060870711 @default.
• W2140396281 cites W2060907452 @default.
• W2140396281 cites W2060951467 @default.
• W2140396281 cites W2061464417 @default.
• W2140396281 cites W2062347996 @default.
• W2140396281 cites W2063206483 @default.

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