Matches in SemOpenAlex for { <https://semopenalex.org/work/W2140397628> ?p ?o ?g. }
- W2140397628 endingPage "162" @default.
- W2140397628 startingPage "153" @default.
- W2140397628 abstract "Background and Objectives Cancer testis antigens (CTA) provide attractive targets for cancer-specific immunotherapy. Although CTA genes are expressed in some normal tissues, such as the testis, this immunologically protected site lacks MHC I expression and as such, does not present self antigens to T cells. To date, CTA genes have been shown to be expressed in a range of solid tumors via demethylation of their promoter CpG islands, but rarely in chronic myeloid leukemia (CML) or other hematologic malignancies.Design and Methods In this study, the methylation status of the HAGE CTA gene promoter was analyzed by quantitative methylation-specific polymerase chain reaction (MSP) and sequencing in four Philadelphia-positive cell lines (TCC-S, K562, KU812 and KYO-1) and in CML samples taken from patients in chronic phase (CP n=215) or blast crisis (BC n=47). HAGE expression was assessed by quantitative reverse transcriptase-polymerase chain reaction.Results The TCC-S cell line showed demethylation of HAGE that was associated with over-expression of this gene. HAGE hypomethylation was significantly more frequent in BC (46%) than in CP (22%) (p=0.01) and was correlated with high expression levels of HAGE transcripts (p" @default.
- W2140397628 created "2016-06-24" @default.
- W2140397628 creator A5001032078 @default.
- W2140397628 creator A5002217376 @default.
- W2140397628 creator A5018111458 @default.
- W2140397628 creator A5018381223 @default.
- W2140397628 creator A5035649117 @default.
- W2140397628 creator A5038175412 @default.
- W2140397628 creator A5045545489 @default.
- W2140397628 creator A5048791177 @default.
- W2140397628 creator A5049487102 @default.
- W2140397628 creator A5053612749 @default.
- W2140397628 creator A5055520887 @default.
- W2140397628 creator A5074532247 @default.
- W2140397628 date "2007-02-01" @default.
- W2140397628 modified "2023-10-18" @default.
- W2140397628 title "Epigenetic regulation of human cancer/testis antigen gene, HAGE, in chronic myeloid leukemia" @default.
- W2140397628 cites W1501664116 @default.
- W2140397628 cites W1540071722 @default.
- W2140397628 cites W1799579309 @default.
- W2140397628 cites W1884583352 @default.
- W2140397628 cites W1963645787 @default.
- W2140397628 cites W1973745530 @default.
- W2140397628 cites W1976463497 @default.
- W2140397628 cites W1985594917 @default.
- W2140397628 cites W1990381590 @default.
- W2140397628 cites W1990946086 @default.
- W2140397628 cites W1994465394 @default.
- W2140397628 cites W1997500900 @default.
- W2140397628 cites W2012828386 @default.
- W2140397628 cites W2013776146 @default.
- W2140397628 cites W2021109810 @default.
- W2140397628 cites W2021712137 @default.
- W2140397628 cites W2028959752 @default.
- W2140397628 cites W2036862498 @default.
- W2140397628 cites W2040250830 @default.
- W2140397628 cites W2041013384 @default.
- W2140397628 cites W2041200806 @default.
- W2140397628 cites W2054746923 @default.
- W2140397628 cites W2058576674 @default.
- W2140397628 cites W2059297569 @default.
- W2140397628 cites W2059656169 @default.
- W2140397628 cites W2071150454 @default.
- W2140397628 cites W2089882703 @default.
- W2140397628 cites W2090004346 @default.
- W2140397628 cites W2093868062 @default.
- W2140397628 cites W2102722090 @default.
- W2140397628 cites W2109895173 @default.
- W2140397628 cites W2116083310 @default.
- W2140397628 cites W2117806883 @default.
- W2140397628 cites W2136460560 @default.
- W2140397628 cites W2146303849 @default.
- W2140397628 cites W2147293836 @default.
- W2140397628 cites W2151069471 @default.
- W2140397628 cites W2162744515 @default.
- W2140397628 cites W2170596459 @default.
- W2140397628 cites W2189013505 @default.
- W2140397628 cites W2316087605 @default.
- W2140397628 cites W2414962234 @default.
- W2140397628 cites W2596224382 @default.
- W2140397628 cites W2799244951 @default.
- W2140397628 cites W2885999730 @default.
- W2140397628 doi "https://doi.org/10.3324/haematol.10782" @default.
- W2140397628 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17296563" @default.
- W2140397628 hasPublicationYear "2007" @default.
- W2140397628 type Work @default.
- W2140397628 sameAs 2140397628 @default.
- W2140397628 citedByCount "51" @default.
- W2140397628 countsByYear W21403976282012 @default.
- W2140397628 countsByYear W21403976282013 @default.
- W2140397628 countsByYear W21403976282014 @default.
- W2140397628 countsByYear W21403976282016 @default.
- W2140397628 countsByYear W21403976282017 @default.
- W2140397628 countsByYear W21403976282018 @default.
- W2140397628 countsByYear W21403976282019 @default.
- W2140397628 countsByYear W21403976282020 @default.
- W2140397628 countsByYear W21403976282022 @default.
- W2140397628 crossrefType "journal-article" @default.
- W2140397628 hasAuthorship W2140397628A5001032078 @default.
- W2140397628 hasAuthorship W2140397628A5002217376 @default.
- W2140397628 hasAuthorship W2140397628A5018111458 @default.
- W2140397628 hasAuthorship W2140397628A5018381223 @default.
- W2140397628 hasAuthorship W2140397628A5035649117 @default.
- W2140397628 hasAuthorship W2140397628A5038175412 @default.
- W2140397628 hasAuthorship W2140397628A5045545489 @default.
- W2140397628 hasAuthorship W2140397628A5048791177 @default.
- W2140397628 hasAuthorship W2140397628A5049487102 @default.
- W2140397628 hasAuthorship W2140397628A5053612749 @default.
- W2140397628 hasAuthorship W2140397628A5055520887 @default.
- W2140397628 hasAuthorship W2140397628A5074532247 @default.
- W2140397628 hasBestOaLocation W21403976281 @default.
- W2140397628 hasConcept C101762097 @default.
- W2140397628 hasConcept C104317684 @default.
- W2140397628 hasConcept C121608353 @default.
- W2140397628 hasConcept C140173407 @default.
- W2140397628 hasConcept C147483822 @default.
- W2140397628 hasConcept C150194340 @default.
- W2140397628 hasConcept C153911025 @default.